Biomedical subjects
W Regan
Publications and source records attributed to W Regan.
On making clinical research count.
Principles of sound research design are inconstantly applied to scientific investigations. Quality research depends on good study design. Many research groups appear to favor quick publishable experiments over more rigorously controlled ones. Clinicians seem inadequately prepared to critically evaluate journal articles for quality of research, clinical relevance, and comparability of reports. Clinicians and researchers alike are increasingly aware of these problems, and are calling for greater attention to research design in scientific work. Authors should explain their procedures and the study's relevance to clinical practice. Educators are encouraged to increase teaching of research design and interpretation of scientific writing.
Plasma lithium stability and a comparison of flame photometry and atomic absorption spectrophotometry analysis.
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Orificial and pulmonary tuberculosis: report of a case.
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Persistent light reaction with Jadit.
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Isolation and characterization of antigenic components of a new heptavalent Pseudomonas vaccine.
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MR assessment of posttraumatic flexion contracture of the elbow.
Preoperative assessment of posttraumatic flexion contracture of the elbow includes plain radiographs and tomograms, which are difficult to obtain in the coronal plane due to the contracture. We conducted this study to determine the usefulness of MR imaging in the work-up of these patients. Twelve patients with flexion contracture of the elbow were studied. In addition to standard spin-echo sequences, a sagittally acquired spoiled gradient-recalled echo 3D data set of the flexed elbow was obtained and reformatted coronally using a curved plane of reconstruction. The MR findings were compared to the plain films, tomograms and surgical results. MRI allowed identification of loose bodies that were sometimes poorly visualized, or not seen, on plain films, and demonstrated degenerative changes equally as well as tomograms. MR showed soft tissue abnormalities including capsular and collateral ligament thickening. Curvilinear reconstructions were helpful in the assessment of collateral ligaments in patients with severe contractures. We conclude that MR is useful in the evaluation of elbow flexion contractures, particularly in assessing soft tissue causes.
Granuloma annulare: an elastic tissue disease? Case report and literature review.
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Microscopic histopathology of chronic refractory lateral epicondylitis.
The histopathologic features from 11 patients who were treated surgically for lateral epicondylitis were graded and compared to similar tissue from 12 cadaveric specimens. All studies were done by a single pathologist who had no knowledge of the origin of the specimen. The surgical specimens were interpreted as abnormal in all 11 specimens, and all 12 of the control specimens were reported as being without histologic abnormality. Vascular proliferation was present in 10 of 11 and focal hyaline degeneration was recorded in all 11 of the surgical specimens. Neither feature was present in any of the control material (P < 0.001). These data suggest that chronic refractory lateral epicondylitis requiring surgery is a degenerative rather than inflammatory process. This may account for the lack of response to rest and antiinflammatory medication.
The central role of actinically degenerate elastic tissue.
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Actinically degenerate elastic tissue: the prime antigen in the giant cell (temporal) arteritis syndrome? New data from the posterior ciliary arteries.
OBJECTIVE: To search for evidence of actinic elastotic degeneration (actinic arteriopathy) and giant cell arteritis (GCA) in the posterior ciliary arteries of eyes from aged white Australians. METHODS: Three hundred donor eyes were given to us by the Lions Eye Bank of New South Wales at Sydney Hospital. Of these, 146 formed the basis of this study. Portions of the posterior ciliary arteries located in relation to the optic nerve heads were processed in paraffin and were then stained by a sensitive haematoxylin and eosin stain that had been especially developed to display actinic elastotic degeneration of elastic tissue. RESULTS: Among 60 "aged" subjects (70-90 yrs.), a total of 41 (approximately 68%) showed definite changes of actinic elastotic degeneration in their laminae, a condition called actinic arteriopathy. One of these subjects revealed giant cells on degenerate lamina, giving a picture regarded as early (pre-clinical) GCA. A young "control" group of 60 subjects 17-59 years of age revealed only one subject with a similar degree of actinic arteriopathy. CONCLUSIONS: Actinic arteriopathy of the posterior ciliary arteries was more frequent and advanced in the "aged", over-70 group as compared with changes in the "young" group < 60 years of age. One aged subject without a history of eye disease showed giant cells associated with elastotically degenerate internal elastic lamina. Her fortuitous lesions are regarded as indicative of how GCA is likely to begin in the damaged arteries.