Plasma levels of penfluridol and thiothixene were studied after 4 weeks treatment in a double-blind controlled trial of 47 patients suffering from chronic schizophrenic syndromes. There was found a tenfold variation in plasma levels for penfluridol, and about a twentyfold variation for thiothixene. For penfluridol, a significant correlation between dosage and plasma level and also between dosage and changes in psychopathology as regards factor 5 in the Märtens & Jonsson S scale which comprises the items most characteristic of a schizophrenic syndrome, was found. For thiothixene, a significant correlation between plasma levels and changes in factor 5 was found. A gas-chromatographic method for penfluridol is also described.

Adult↗

PubMed1975

Quantitation of alpha1-acid glycoprotein in neutralized gastric juice by electroradioimmunoassay (ERIA).

Alpha1-Acid glycoprotein (AGP) was quantitated by an electroradioimmunoassay (ERIA) in in vivo neutralized gastric juice (nGJ) of 226 patients, including normals and patients with various gastic diseases. The accuracy of ERIA was tested by extraction and recovery experiments. A possible interference of nGJ constituents with the quantitation procedure was excluded. The mean AGP concentration in gastric juice of normals was 1.04 mu/ml (range 0.04-4.1 mu/ml). The concentration was significantly higher in the gastric cancer group (mean 31.6 mu/ml, p less than 0.01), in the group of chronic metaplastic gastritis (mean 5.7 mu/ml, p less than 0.01) and in the group of BII resections (mean 8.8 mu/ml, p less than 0.05). In 6 out of 12 nGJ samples with high AGP concentrations, a spur formation (Ouchterlony type III) was observed in double gel diffusion when compared to serum AGP. In 3 out of these 12 samples, the dilution curve in ERIA differed from the serum AGP dilution curve. These results indicate a difference in the antigenic properties of AGP in nGJ.

Adolescent↗

PubMed1975

Alpha 1-acid glycoprotein in gastric cancer juice.

Gastric juice was neutralized (nGJ) in vivo by 80 ml of a phosphate buffer containing radiolabelled vitamin B12 as dilution indicator. Unprocessed nGJ was analyzed in the double gel diffusion technique for the presence of serum proteins using monospecific antisera. Alpha1-Acid glycoprotein (AGP) was found in a high incidence (36 out of 38 subjects) in nGJ of gastric cancer patients. AGP was also observed less frequently in nGJ of patients with Billroth II resections (6/15), metaplasia (11/52), gastric ulcer (3/24), chronic atrophic gastritis (2/26) and chronic gastritis (3/63). AGP was absent in the control group (0/21), in patients with surface gastritis (0/38) and in subjects with normal acid secretion (0/45). Immunochemical studies demonstrated no identity of AGP with human "gastrointestinal tumor associated antigens." In 7 out of 17 AGP positive samples immunochemical differences between gastric and serum AGP were observed.

Adolescent↗

PubMed1974