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Biomedical subjects

W R Tyldesley

Publications and source records attributed to W R Tyldesley.

At least 37 records · Page 2Linked to original sources
PubMed1979

Oral Crohn's disease and related conditions.

It has become widely recognised that oral lesions may occur in patients with Crohn's disease of the lower gastro-intestinal tract. Patients have also been described with oral lesions of this kind unassociated with gut lesions. The purpose of this paper is to describe the clinical presentation of seven such patients. The resemblance of their lesions to those of the condition known as chronic granulomatous cheilitis is pointed out. The association between the oral lesions and those of the lower gut is discussed and it is reported that in one patient acute toxic dilation of the colon due to Crohn's disease followed a period in which oral lesions only were recognised.

Adult↗
PubMed1979

Oral lesions in renal transplant patients.

Plaque-like lesions of the oral mucosa have been observed in seven immunosuppressed renal transplant patients. Whilst bearing a superficial resemblance to acute pseudomembranous candidiasis (thrush), these lesions have been shown to be associated with bacterial overgrowth and not with fungi. Treatment has depended on the use of appropriate antibiotics and antiseptics together with the adoption of measures to cause disintegration of the mucoid matrix of the lesions.

Adult↗
PubMed1978

Scanning electron microscopy of oral epithelial cells. Part I. Normal and malignant tissue.

The surface features of cells removed by scraping from normal human oral mucous membrane and from squamous cell carcinomas of the oral mucosa were examined by scanning electron microscopy. It was concluded that in normal oral mucosa the cell surface morphology is dependent on the state of keratinisation of the tissue. Malignant cells were observed to display modified surface characteristics which have been tabulated. It is suggested that these characteristics may be of value in the diagnosis of malignancy.

Adult↗
PubMed1978

Scanning electron microscopy of oral epithelial cells. Part II. Potentially malignant lesions (a computer-assisted study).

The technique described in Part I, has been extended to the examination of cells removed by scraping from 22 lesions of oral lichen planus and leukoplakia. It was concluded that the surface morphology of the cells from these lesions was intermediate between that of normal tissue and of malignant tissue. The observations have been quantified and subjected to computer analysis together with the data derived from the observations of normal and malignant tissue. This confirms the visual observation that a relationship exists between the modified surface characteristics of the cells from these lesions and their subjectively assessed histological appearances. A correlation has been found between the SEM appearance and an epithelial atypia index (EAI) derived according to the criteria of Smith and Pindborg (1969). In the case of lichen planus inflammatory changes appear to be associated with increased modification of surface characteristics. These changes are also reflected in an increased EAI. It is suggested that the present technique may be of value in the diagnosis and assessment of potentially malignant lesions.

Adult↗
PubMed1977

Betamethasone valerate aerosol in the treatment of oral lichen planus.

Betamethasone valerate aerosol, given in doses of up to 800 microgram per day, was compared with placebo in a double-blind trial involving 23 patients with oral lichen planus. The majority of patients receiving the active aerosol noted improvement within the first 2 weeks of treatment and at 8 weeks the lesions had almost cleared; in contrast, only 2 patients on placebo showed slight improvement over the same time period. The results suggest that this form of treatment is an effective and acceptable method of controlling the discomfort due to oral lichen planus, especially where minor erosions are present.

Adult↗
PubMed1975

Haemangioma of the maxilla: a case report.

A rapidly expanding central haemangioma of the left maxilla in a 7-year-old boy was treated by ligation of the left external carotid and facial arteries and of the major vessel draining the lesion. Clinical and radiographic regression of the lesion has followed this treatment. Possible alternative approaches are discussed, as are the appropriate diagnostic techniques.

Angiography↗
PubMed1975

Ultrastructure of the oral epithelium in leukoplakia associated with tylosis and esophageal carcinoma.

Ultrastructural studies have been carried out on epithelium taken from the oral lesions of tylosis-related leukoplakia and preleukoplakia in a group of patients known to be at high risk for esophageal carcinoma. Several structural abnormalities are described; in particular, the presence of intranuclear electron dense particles 90 nm in diameter. Similar particles have been found in the nuclei of epithelial cells from an esophageal carcinoma developing in one of the patients under study.

Basement Membrane↗
PubMed1975

The teeth.

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Amelogenesis Imperfecta↗
PubMed1974

Oral lichen planus.

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Administration, Topical↗