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Biomedical subjects

W R Turner

Publications and source records attributed to W R Turner.

At least 37 records · Page 2Linked to original sources
PubMed1981

Synthesis and antitumor activity of 7-O-(3,4-di-O-acetyl-2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)adriamycinone.

The title compound (7), the 3'-acetoxy-4'-O-acetyl analog of adriamycin (doxorubicin), was synthesized in approximately 50% net yield from daunomycinone by bromination at C-14, glycosylation of the product at O-7 with 3,4-di-O-acetyl-2,6-dideoxy-alpha-L-lyxo-hexopyranosyl chloride, and replacement of the 14-bromo substituent by a hydroxyl group; other possible routes to 7 gave lower yields. The product 7, a non-aminated analog of the anthracycline antibiotics, showed high antitumor activity coupled with low acute toxicity in a broad range of tests in mice.

Animals↗
PubMed1980

Patterns of renal damage in the management of vesical exstrophy.

We reviewed the patterns of pyelonephritic damage that occurred during surgical management of bladder exstrophy. Renal injury patterns indicate that papillary configuration and obstruction coupled with urinary infection were the primary factors in producing damage. Diversion by the ileal conduit resulted in frequent injury, whereas the colon conduit was associated rarely with renal damage. The incidence of renal injury from bladder closure and continence attempts suggested closure as a reasonable course, especially in view of present continence results.

Bladder Exstrophy↗
PubMed1980

Variants of the exstrophic complex.

In the split symphysis variant, a rare anomaly of bladder exstrophy, the bladder is closed with varying degrees of skin covering it. A good prognosis does exist for surgically produced continence in patients with a single bladder, although patients with bladder duplication have a greater risk of renal damage.

Bladder Exstrophy↗
PubMed1977

Urologic manifestations of Henoch-Schönlein purpura.

Henoch-Schönlein purpura involves the kidneys in about 50 per cent of cases. In adults the classic signs are usually absent. Open renal biopsy is valuable from a prognostic standpoint since the severity of the renal lesion can be correlated with the future clinical course.

Adult↗
PubMed1977

Retrospective study of 95 patients with staghorn calculus disease.

Medical records were reviewed for 95 consecutive patients hospitalized with a diagnosis of staghorn calculus disease. Of those patients in whom a conservative, non-operative approach was taken 30 per cent ultimately died of renal failure and/or sepsis. It is concluded that surgical intervention is the treatment of choice for patients with staghorn calculus disease.

Female↗
PubMed1977

Benign lesions of the tunica albuginea.

Although most testicular masses are malignant we present 7 cases to demonstrate that benign lesions of the tunica albuginea do occur and that these may be a source of diagnostic confusion. Consideration should be given to the possibility of a benign lesion of the tunica albuginea when the lesion is small, discrete, painless and projecting above the surface of the tunica albuginea. All of our patients were referred to us with a tentative diagnosis of testicular malignancy. We do not wish to decrease the importance of vigilance concerning testicular masses but the cases presented herein demonstrate that all masses of the testis are not malignant.

Adult↗
PubMed1976

Polarographic determination of isosorbide dinitrate.

Isosorbide dinitrate and two isomeric isosorbide mononitrates are shown to be polarographically reducible in aqueous sodium perchlorate or potassium chloride solution. The current, measured at -1.6 v, versus the saturated calomel electrode is proportional to the concentration of organic nitrate in the 10-100-mug/ml range. Inorganic nitrate produces no interference. However, the mononitrate isomers produce an additive response to isosorbide dinitrate and cannot be determined individually. The polarographic method is applicable to single-tablet assay for content uniformity determination, with precision and accuracy comparable to automated colorimetric analysis. Comparison is made between replicate analyses obtained polarographically and by IR and automated colorimetric analysis for six different commercially available formulations. The polarographic determination is sensitive, specific for nitrate esters, precise, requires little sample preparation, and utilizes relatively inexpensive apparatus.

Autoanalysis↗
PubMed1976

Leydig cell tumor in identical twin.

A case is presented of an identical twin who had an interstitial cell tumor of the testis removed, and comparison is made with his identical brother over an ensuing six-year period. The dramatic effects of the interstitial cell tumor are clearly shown in the comparison of the two males over this six-year period. To our knowledge this is the only such case in the world literature.

Adolescent↗