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Biomedical subjects

W R Timperley

Publications and source records attributed to W R Timperley.

At least 55 records · Page 3Linked to original sources
PubMed1984

Cerebrospinal fluid enolase in stroke.

This study relates the level of alpha and gamma enolase in cerebrospinal fluid sampled within 4 days of a stroke to the volume of the cerebral infarct measured on the CT image and to the clinical outcome of the patient. Twenty-eight patients were studied, two with transient ischaemic attacks and 26 with completed stroke due to infarction. The cerebrospinal fluid enolase was raised in the two patients with transient ischaemic attacks and 23 with completed stroke. There was a positive correlation between the volume of the infarct and the level of cerebrospinal fluid alpha and gamma enolase. A high cerebrospinal fluid enolase was always associated with a poor prognosis.

Adult↗
PubMed1983

Enolase isoenzymes in uveal melanomas--a possible parameter of malignancy.

Seven uveal melanomas were stained for gamma enolase by an immunoperoxidase PAP (peroxidase-antiperoxidase) technique, and biochemical assays were carried out on tissue homogenates. A correlation between the biochemical assay and the immunoperoxidase staining was demonstrated. Two tumours with the highest biochemical assays showed positive staining for the enzyme, and 2 tumours with the lowest levels showed no appreciable staining. The highest level of enolase was present in a tumour which both clinically and histologically appeared to be benign, and the lowest level occurred in a mixed cell tumour which was large in size; the low level presumably related to its relatively fast rate of growth. Estimation of gamma enolase activity in ocular melanomas may provide an accurate quantitative method for assessing the malignant potential of these tumours.

Adult↗
PubMed1983

An unusual brainstem capillary telangiectasis in a child.

This case report concerns a brainstem telangiectasis that mimicked a tumor causing progressive neurologic symptoms over a period of 6 years prior to death. Intravascular coagulation within the malformation leading to localized ischemia is proposed as the mechanism for the apparent growth of the lesion.

Brain Neoplasms↗
PubMed1982

Banning boxing.

Explore the source record for details and available documents.

Athletic Injuries↗
PubMed1982

Enolase isoenzyme distribution in the human brain and its tumours.

Using the immunoperoxidase PAP method we have studied the cellular distribution of alpha, beta and gamma enolase subtypes in normal human adult brain and in human brain neoplasms. Gamma enolase is found only in viable neurones throughout the brain. Alpha enolase is demonstrable in astrocytes, ependymal cells, capillary endothelial cells. Schwann cells and arachnoidal endothelial cells but oligodendrocytes appear to have low levels of this isoenzyme. Beta enolase is not demonstrable in normal brain tissues. Of the primary cerebral neoplasm studied only medulloblastomas and neuroblastomas did not contain demonstrable enolase. Astrocytomas, ependymomas, oligodendrocytomas, meningiomas and acoustic neuromas all contained varying quantities of alpha enolase. No cerebral tumours contained beta or gamma enolase. Tumour and adjacent brain tissue with histological evidence of ischaemia and necrosis showed loss of cellular enolase.

Adolescent↗
PubMed1981

Levels of enolase and other enzymes in the cerebrospinal fluid as indices of pathological change.

The activities of enolase, aldolase, pyruvate kinase, lactate dehydrogenase and creatine phosphokinase were measured in cerebrospinal fluid of 121 patients presenting with a range of disorders of the central nervous system. The results from 41 patients undergoing myelography were used as controls. An assessment was made of the relative merits of these five enzymes as markers of brain damage with special reference to brain tumours. Enolase was the most sensitive marker of pathological change and was the only enzyme raised in the CSF of patients with low grade astrocytomas.

Adenoma↗
PubMed1981

Intracerebral cyst due to ectopic choroid plexus: case report.

A case of supratentorial intracerebral cyst, containing ectopic plexus, is discussed. The cyst had no communication with the ventricular system or subarachnoid space. The cyst wall was lined in part by flattened or cuboidal epithelium and in part by glia. Fronds of choroid plexus protruded into the cavity of the cyst in one part. The preoperative and postoperative computerized tomography scans are presented and the operative findings are discussed. The management of such cases is reviewed.

Adult↗
PubMed1980

Electron microscopical studies of vessels in diabetic peripheral neuropathy.

the results of an electron microscopical study of sural nerve biopsies from 11 patients with diabetic neuropathy are presented. Thrombi were seen in six cases in at least one intraneural vessel; nine cases showed hyperplasia of endothelial cells, and in seven out of these nine the hyperplasia was sufficient to occlude completely the lumen of small vessels; six cases showed degenerate pericytes and endothelial cells, and in some cases endothelial cells had been shed from the vessel wall, exposing the blood within the vessel to the underlying basement membrane; in five cases large lipid droplets were seen within endothelial cells. Abnormalities of the vessel wall would result in decreased fibrinolytic activity and a reduction of the antiplatelet aggregating proprties of the vessel. Desquamation of endothelial cells from the vessel wall, with exposure of platelets to underlying collagen, may act as a trigger for thrombus formation, particularly as the blood of diabetic patients is often in a hypercoagulable state. The significance of hyperplasia of endothelial cells is at present unknown but, once established, this too would result in profound alterations of loal blood flow and ischaemia of nerve. Damage to endothelial cells may also allow seepage of haematological constituents into the vessel wall, resulting in its progressive thickening.

Adult↗
PubMed1979

The CT scan and subtraction angiography in chemodectomas.

The value of subtraction angiography and CT scanning in the diagnosis of chemodectomas are illustrated by two cases, a glomus jugulare tumour which exhibited true malignant behaviour, and a carotid body tumour. The characteristic early arterial blush of a chemodectoma, which can be obscured by bone, is clearly seen following subtraction techniques revealing tumours as small as 0.5 cm. The chemodectoma appeared as an isodense tumour on the CT scan with uniform contrast enhancement and well-defined margins. The appearances, however, are not diagnostic of a chemodectoma and may be simulated by other tumours.

Adult↗
PubMed1978

Elevated beta-thromboglobulin levels and circulating platelet aggregates in diabetic microangiopathy.

beta-Thromboglobulin levels and platelet-aggregate ratios were determined in blood-samples from healthy control subjects and from diabetic patients with and without microangiopathic complications. Patients with diabetic microangiopathy had significantly elevated beta-thromboglobulin levels and also reversible platelet aggregates. In nine newly treated diabetics blood-glucose control was associated with a significant fall in plasma beta-thromboglobulin. Since beta-thromboglobulin is a platelet-specific protein the results indicate that diabetic microangiopathy is associated with evidence of platelet activation and that this may be influenced by the degree of biochemical control.

Aged↗
PubMed1977

Cerebral involvement with disseminated intravascular coagulation in intestinal disease.

Over a two-and-a-half-year period at the Sheffield Royal Infirmary, six patients developed disseminated intravascular coagulation as a serious complication of intestinal disease. There was clinical evidence of cerebral involvement in all six patients, and small vessel thrombi were demonstrated in the brains of all three cases examined post mortem. Where the true significance of the cerebral disorder was not recognised, this led to delay in the diagnosis with serious risk to the patient. In the single case in which the diagnosis was made early, the intravascular coagulation was completely reversed with heparin therapy.

Adult↗