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Biomedical subjects

W R Solomon

Publications and source records attributed to W R Solomon.

46 records · Page 3Linked to original sources
PubMedDate not supplied

Effect of ammonia on nasal resistance in atopic and nonatopic subjects.

Nasal airway resistance (NAR) was assessed from the slope of pressure-glow curves obtained during normal nasal breathing. Volunteers were classified as atopic or nonatopic according to strict critera. 100 ppm NH3 was introduced into each nostril for periods ranging from 5 to 30 seconds with frequent NAR monitoring. A progressive increase in NAR responses was obtained with incremental NH3 exposure, but no significant difference was noted between the mean response of atopic and nonatopic subjects. Control exposures to compressed air under the same pressure generally produced only a small change in NAR, while aerosolized buffered saline increased NAR more than compressed air. The nasal response to NH3 was effectively inhibited by intranasal atropine administration but not by chlorpheniramine. The nasal response to NH3 was effectively inhibited by intranasal atropine administration but not by chlorpheniramine. The described procedure provides a safe and simple method for studying semiquantitatively the short-term effects of inhaled irritants on the nose.

Air↗
PubMedDate not supplied

Assessing the animal associated environment.

Although assessments of the animal associated environment remain largely at the stage of gross description, it is clear that more precise and comprehensive expressions of resulting exposure are desirable. Both the problems to be overcome and the means of addressing technical imperatives have been characterized, and it appears that interest in this area will soon enter a "log phase" of growth. As a result, we may hope soon to deal with animal allergens in quantitative terms of dose and response and to appreciate how indoor ecosystems modulate challenge. It is realistic to hope that allowable exposure limits may follow and that from these will emerge innovative strategies ensuring healthful human-animal interactions.

Allergens↗