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Biomedical subjects

W R Pitt

Publications and source records attributed to W R Pitt.

22 records · Page 2Linked to original sources

Radionuclide image minification can compensate for coarse digitization: concise communication.

Although it is common practice to digitize radionuclide images onto the finest matrix available, their low count densities and poor spatial resolution suggest that quite large pixels should be adequate. Observers find these large pixels visually obtrusive, but minification of the image can reduce this effect. Experiments reported here have investigated how minification (achieved by increasing viewing distance) affects the perceived quality of images digitized onto different sized matrices. Observers' subjective preference for different pixel sizes was measured at various viewing distances using clinical bone images as test patterns. An objective measure of image quality was made by comparing the detectability of computer-generated focal areas of increased activity both in simple noisy backgrounds and in clinical bone images. The results show that a 128 X 128 matrix is adequate when the image is 8 cm2 and is viewed from 1 and 2 m. A finer matrix failed to produce better results.

Bone and Bones↗

Single dose trimethoprim-sulphamethoxazole treatment of symptomatic urinary infection.

Seventy-nine children with symptoms of urinary tract infections were randomly allocated to treatment with a single dose or a 7-day course of trimethoprim-sulphamethoxazole. Of the 42 patients (39 girls, 3 boys) who fulfilled the criteria for the trial, 23 were given a single-dose regimen and 19 of them a 7-day regimen. Both groups of patients had sterile urine cultures 2 days after starting treatment. Eight patients had underlying structural renal abnormalities (n = 3, single-dose regimen; n = 5, 7-day regimen). One patient in the single dose group had a recurrence of infection on day 7. These results show that single dose trimethoprim-sulphamethoxazole is as effective as the conventional 7-day course in children with symptomatic urinary tract infection. Further investigation of the renal tract is necessary regardless of the fact that the infection has been eradicated by single-dose treatment.

Child↗

Reproducibility of gamma camera data.

The increasing use of quantification in the interpretation of nuclear medicine images requires a knowledge of the errors associated with the estimation of the activity in a volume of interest from the recorded count rate data. Using sources of known cross-sectional area from 1 to 25 cm2, errors caused by variations in the count rate, day of measurement, source position in the camera field of view, and source size are evaluated. The effect of source depth in tissue-equivalent (TE) medium on the reproducibility of the data is also investigated. For a given source size at a known depth, variations in camera response lead to an error (SD) of a least 6% that increases as either the source size or the depth of the source in TE medium is increased. Failure to estimate accurately the true depth of the organ can also be a major source of error. The use of two conventional types of flood correction technique ('count-skipping' and matrix division) is found to increase the error only in the case of the smallest source.

Models, Structural↗