Organizing American dermatology and the founding of the American Academy of Dermatology.
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Academies and Institutes↗
Biomedical subjects
W R Hubler
Publications and source records attributed to W R Hubler.
The Committee on History of the American Academy of Dermatology.
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Academies and Institutes↗
Solar elastotic bands of the forearm: an unusual clinical presentation of actinic elastosis.
Actinic damage of dermal tissues produces several distinct clinical patterns. Three patients are described as having discrete, soft, cordlike bands on the forearms that extend from dorsal areas of actinic damage and senile purpura to greatest prominence in flexural regions with less solar damage. Histochemical analyses and light and electron microscopy studies of the plaques showed changes consistent with solar elastosis. The clinical variants of actinic elastosis and the possible origins of the abnormal elastic fibrils found in the dermis of chronically sun-damaged skin are discussed. Solar elastotic bands are an unusual form of actinic degeneration.
Aged↗
Lingual lesions of generalized pustular psoriasis. Report of five cases and a review of the literature.
Geographic tongue and fissured tongue may be mucosal manifestations of generalized pustular psoriasis. All three disorders have polygenic inheritance patterns and affected patients may share genes. Five patients in three families with geographic tongue, fissured tongue, and generalized pustular psoriasis are described and the lingual lesions of generalized pustular psoriasis are reviewed.
Adult↗
Familial juvenile generalized pustular psoriasis.
The acral form of generalized pustular psoriasis is characterized by macroscopic pustules surmounting erythematous plaques that may progress from a localized distal eruption to involve the entire cutaneous surface. Juvenile-onset and familial-generalized pustular psoriasis are rare; familial-juvenile-generalized pustular psoriasis is exceptionally uncommon. A kindred of three children in the same generation had chronic, localized-acral pustular psoriasis and episodic-generalized pustular psoriasis.
Acrodermatitis↗
Dermatitis from a chromium dental plate.
Systemic absorption of metal or metallic salts from dental and orthopedic surgical implants can produce a cutaneous allergic dermatitis in susceptible individuals. Mercury, nickel and cobalt are the most common metals to elicit such systemic allergic reactions from chronic internal exposure. A case is presented of a generalized eczematoid dermatitis apparently caused by allergy to chromium liberated from a metal dental plate.
Aged↗
Milia en plaque.
Two patients with an unusual cutaneous lesion consisting of milia on an erythematous edematous base are presented; the clinical and histologic features are described. The name "milia en plaque" is proposed for this unusual condition.
Adult↗
Nevus anemicus. Donor-dominant defect.
Histologic, pharmacologic, and exchange transplant studies were performed on a patient with nevus anemicus. Histologic examination disclosed no abnormalities. The only pharmacologic stimulus that produced erythema within the nevus was the alpha-blocking agent, phentolamine mesylate. Results of the transplant studies demonstrated donor dominance. This suggests that the defect in the nevus anemicus is attributable to increased sensitivity of the blood vessels to catecholamines rather than to increased alpha-adrenergic stimulation.
Hemangioma↗
Hypomelanotic canopy of sarcoidosis.
A case of cutaneous hypopigmented macules localized above deep dermal and subcutaneous sarcoid granulomas in a patient with systemic sarcoidosis is presented. Melanin was only sparsely distributed in the upper stratum malpighii. Hypopigmentation is an unusual manifestation of sarcoidosis. With an armamentarium of clinical observation, dermatologists may suspect a hypomelanotic cutaneous diadem overlying a palpable dermal mass to be a visual vignette of a sarcoidal montage requiring diagnostic biopsy.
Adult↗
Psoriasis: the angiogenic alternative.
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Angiogenesis Inducing Agents↗
Melanoma. Tumor angiogenesis and human neoplasia.
Transparent hamster-cheek-pouch chambers were used to document angiogenesis induced by implants of human malignant melanoma. Capillary proliferation was observed with direct implantation of melanoma fragments and with tumor implants place on microporous membrane filters. The pattern of capillary neovascularization was recorded and correlated with clinical and histopathologic parameters.
Animals↗
Photosensitivity papules--a cutaneous sign of systemic disease: erythropoietic protoporphyria.
Erythropoietic protoporphyria is an unusual autosomal dominant syndrome characterized by increased deposits of protoporphyrin in erythrocytes, liver, feces, and skin. Symptomatic chronic cutaneous papules in sun-exposed areas, cholelithiasis, cirrhosis, hepatic failure, and anemia are manifestations of this systemic disorder. Treatment of cutaneous symptoms is with oral beta-carotene, but there is no effective control for internal manifestations.
Adult↗
Epidemic Norwegian scabies.
Norwegian scabies is an ectoparasitic infestation by Sarcoptes scabiei, characterized by hyperkeratotic lesions of the hands, feet, ears, and scalp, which contain many mites. An epidemic of Norwegian scabies involved 22 patients in a 25-patient ward of mentally and physically handicapped persons (mostly mongoloids). The pathogenesis of the prolific mite population is unclear, but either a specific immunologic deficit or the inability to effectively eliminate the mites by scratching is a plausible possibility.
Adolescent↗
Actinomycotic mycetoma treated with minocycline: case report.
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Adult↗
Tumour angiogenic factor associated with subcutaneous lymphoma.
Growth and survival of cutaneous neoplasms are dependent on the development of a nutrient-supplying vascular lifeline. A subcutaneous lymphoma is described which mimicked a vascular neoplasm because of the extensive telangiectasia overlying the tumour. Fragments of the lymphoma inserted in direct apposition to the hamster cheek pouch membrane or separated from the membrane by a microporous filter both induced dramatic neovascularization. Control materials failed to induce significant vascular changes. A diffusable Tumour Angiogenic Factor may play a vital role in tumour survival and portends a therapeutic potential.
Angiogenesis Inducing Agents↗
Tumor angiogenic factor and human skin tumors.
A transparent acrylic hamster cheek-pouch chamber was used to investigate the elaboration of a tumor angiogenic factor (TAF) by human cutaneous neoplasms; direct tumor implantations, transfilter diffusion, and soluble tumor extracts were used in the study. A diffusible and filterable TAF was extracted from cutaneous tumors and produced distinctive patterns of sequential vasodilatation, tortuosity, and neovascular proliferation in the cheek-pouch membrane. Malignant human neoplasms (eg, melanoma, basal cell epithelioma, squamous cell carcinoma, lymphoma) produced striking neovascularization; vascular tumors (eg, Kaposi sarcoma, pyogenic granuloma, vascular histiocytoma) stimulated dramatic hyperemia and ectasia. Angiogenesis was conspicuously absent after implantation of control materials and nevoid or normal cutaneous components (with the exception of epidermis). Tumor angiogenic factor appears to induce direct stimulation of endothelial cell mitosis and may be essential for survival of nutritionally ravenous neoplastic tissues. The interference with TAF has therapeutic implications.
Acrylates↗