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Biomedical subjects

W R Gray

Publications and source records attributed to W R Gray.

At least 91 records · Page 5Linked to original sources
PubMed1978

Computed tomography for localization and sizing of experimental acute myocardial infarcts.

Computed tomography (CT) has been used to quantitate acute myocardial infarct size in isolated, arrested canine hearts. Acute myocardial infarcts were produced in 20 hearts by either left anterior descending (13 dogs) or circumflex coronary artery ligation (seven dogs). Each animal was given iodinated contrast media intravenously immediately before sacrifice 24--72 hours postinfarction. All infarcts greater than 1 g and one of three infarcts 0.5 g or less were detected by CT imaging. Infarct volume determined by CT correlated with gross infarct weight (r=0.83). CT imaging, however, consistently underestimated infarct volume; underestimation was largest in a group of patchy, predominantly subendocardial infarcts. As adequate equipment and techniques for in vivo studies are developed, CT imaging of the heart may become important in clinical evaluation of myocardial infarction.

Acute Disease↗
PubMed1977

Evolution of elastin structure.

The aortae of a number of vertebrates and invertebrates were tested for the presence of elastin to determine when this protein first appears phylogenetically. Using several criteria, including amino acid composition, presence of desmosines, and histological characteristics, we found that all representative vertebrate groups have elastin except the primitive jawless fishes (lampreys and hagfishes). All the invertebrates tested, representing most major phyla, were found lackin in elastin as well. Comparison of purified elastins from several vertebrate groups reveals some striking differences in their amino acid compositions and properties, including the arrangement of the elastic fibers in the aorta. The patterns of variations in amino acid composition suggest a mode of evolution which is different from the slow accumulation of point mutations observed with globular proteins.

Amino Acids↗
PubMed1977

Computed tomography: in vitro evaluation of myocardial infarction.

An in vitro study of computed tomographic (CT) scanning of experimental myocardial infarction (MI) was performed by studying isolated canine hearts 18 to 48 yrs. post-infarction. CT scanning does not detect histologically present calcification in the area of an MI, but can be used to identify wall thickness changes in these areas. Decreased attenuation coefficients are found infarcted myocardium where thinning is present. The potential CT scanning to detect areas of MI is confirmed.

Animals↗
PubMed1977

Renal displacement visualized on myocardial scintigram: case report.

Myocardial scinitgrams, using 99mTc-stannous pyrophosphate, showed an acute posterior infarction and an abnormally placed left kidney in a 24-year-old hypertensive man; Further study revealed that the kidney was displaced by a mass later proven to be a pheochromocytoma. The latter was the cause of his hypertension and probably instigated the acute myocardial infarction.

Adult↗
PubMed1971

The isolation and functional identification of a protein from the human erythrocyte 'ghost'.

A protein, initially identified as a band on polyacrylamide-gel electrophoresis of erythrocyte ;ghosts', was isolated by selective extraction of ;ghosts' with EDTA solutions. The molecular weight of the polypeptide chain was estimated as 33000 and it represents approx. 5% of the membrane protein. The N-terminal sequence of the protein was established. Comparison with known protein sequences suggested that the protein might be the erythrocyte d-glyceraldehyde 3-phosphate dehydrogenase. This identification was confirmed by direct enzyme assay. It is suggested that this enzyme, which is strongly retained by erythrocyte ;ghosts' on haemolysis of erythrocytes, is unlikely to be an integral part of the structure of the erythrocyte membrane.

Acrylamides↗