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Biomedical subjects

W R Bell

Publications and source records attributed to W R Bell.

206 records · Page 12Linked to original sources
PubMedDate not supplied

A prospective study of the effect of dextran administration on compatibility testing.

The effects of dextran therapy on pretransfusion compatibility testing were evaluated in 24 patients with a variety of vascular disorders. Specimens were drawn before, during, and after the administration of low-molecular-weight dextran (average molecular weight, 40 kd). Forty-three specimens were studied extensively with several immunohematologic techniques. Dextran levels were measured to determine whether the concentration influenced the results of serologic tests. In no instance could we demonstrate any interference by dextran with pretransfusion tests, even at high serum levels of dextran.

Blood Banks↗
PubMedDate not supplied

Natural history of autologous blood clot embolization in swine.

Previous studies of the natural history of embolized clots in dogs have demonstrated rapid lysis, presumably because the canine fibrinolytic system is very active. The fibrinolytic activity in swine, however, is similar to humans, and for this reason the pig was chosen for our study. The gluteal branches of the external iliac artery in nine domestic swine were embolized with either unmodified or modified (heat-formed, Amicar) autologous clot. In addition, three pigs were embolized with unmodified autologous clot to branches of the gastrosplenic artery. The lysis of clot emboli in both groups was followed by serial angiography at 48 hours and 14 days. Clot lysis as assessed by euglobulin lysis and plasmin generation was not activated by the experimental technique. Necropsy was performed on the animals in the second group. Partial or total obstruction of all arteries was present 48 hours after embolization and only 50% of arteries were recanalized at 14 days. At necropsy, organized partially occluding clot was demonstrated in the splenic artery of all 3 embolized swine. It is concluded that: 1)swine provide an excellent animal model for studying the natural history of arterial embolization; 2)Amicar or heat-formed clot shows no advantage over simple autologous clot in retarding intra-arterial clot lysis, and 3)simple autologous clot is an effective material for temporary intra-arterial occlusion.

Animals↗
PubMedDate not supplied

Cytologic diagnosis of occult small-cell undifferentiated carcinoma of the lung.

Small-cell undifferentiated carcinoma of the lung is usually metastatic and/or locally advanced at diagnosis. We describe an occult tumor that cytologic techniques diagnosed in a minimally symptomatic, high-risk individual. Despite the absence of radiologic or histopathologic confirmation, bronchoscopically directed cytologic specimens localized the lesion. A tiny, apparently stage I, small-cell undifferentiated carcinoma was successfully resected.

Carcinoma, Small Cell↗