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W R Barclay

Publications and source records attributed to W R Barclay.

At least 91 records · Page 5Linked to original sources
PubMed1973

Changing of the guard.

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American Medical Association↗
PubMed1970

Aerosol-Induced Tuberculosis in Subhuman Primates and the Course of the Disease After Intravenous BCG Vaccination.

Suitability of the rhesus monkey (Macaca mulatta) as an experimental host for evaluation of vaccines against airborne infection with Mycobacterium tuberculosis strain H37Rv was investigated. Nonvaccinated monkeys were exposed to estimated doses of 12, 25, or 49 units of H37Rv in a modified Henderson apparatus, and the course of the disease was followed by chest X rays, skin testing with purified protein derivative, body-weight determinations, and autopsy 8 weeks postinfection. These animals developed progressive and extensive tuberculosis with pathological changes proportional to the infecting dose. Four of seven monkeys vaccinated intravenously with 1 mg of live BCG 8 weeks prior to challenge with 40 units of H37Rv had no gross evidence of disease at autopsy 13 weeks postinfection; the other three monkeys had minimal disease. These data demonstrated that (i) reproducible and progressive infection could be induced in rhesus monkeys infected in a manner which simulated natural infection of man and (ii) a high level of resistance to infection could be induced by BCG vaccine in the rhesus monkey, which in nature is highly susceptible to tuberculous infection.

Journal Article↗
PubMed1967

Effects of oil-treated mycobacterial cell walls on the organs of mice.

Intravenous vaccination of mice with oil-treated mycobacterial cell walls resulted in a marked macrophage accumulation in the lungs and spleens of vaccinated animals. Injection of oil emulsion alone or of cell walls alone failed to elicit the macrophage response. Although a correlation existed between the magnitude of the macrophage response and the degree of immunity against aerosol challenge with H(37)Rv organisms, the findings presented here do not rule out the possibility that qualitative differences may be present in the macrophages of animals vaccinated against tuberculosis. The ability of oil-treated cell walls to elicit an immune response appeared to be a function of the physical association of cell wall fragments and the surface of oil droplets.

Aerosols↗