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Biomedical subjects

W R Anderson

Publications and source records attributed to W R Anderson.

150 records · Page 9Linked to original sources
PubMedDate not supplied

An ultrastructural study of the membranoproliferative variant of transplant glomerulopathy.

In this study we analyzed the ultrastructural features of the membranoproliferative variant of transplant glomerulopathy in 6 patients from a group of 64 renal transplant recipients who had evidenced graft dysfunction and histological diagnosis of chronic allograft rejection. The principle changes observed by electron microscopy were thickening of glomerular basement membranes by polymorphous changes that included widening of the lamina rara interna by an electron lucent material resembling plasma constituents, replication of lamina densa-like material, and inclusion of microfilaments, membranous profiles, and other cellular remnants. Proliferation of endothelial cells was a prominent finding, suggesting that a reparative endothelial response to injury may be significant to the pathogenesis of this form of transplant glomerulopathy.

Fluorescent Antibody Technique↗
PubMedDate not supplied

Bronchopulmonary dysplasia: a correlative study by light, scanning, and transmission electron microscopy.

The sequential stages of bronchopulmonary dysplasia occurring in 18 infants after intensive respiratory therapy supplemented by oxygen in high concentrations were studied by correlative light, scanning, and transmission electron microscopy. Infant survival ranged from 3 to 225 days. The earliest stage was an exudative reaction with a predominance of hyaline membranes. This merged with a subacute reparative response that was replaced by a chronic fibroproliferative stage in infants of longest survival; this stage was complicated by pulmonary fibrosis and emphysema. Correlative scanning and transmission electron microscopy demonstrated that type 2 pneumocytes contributed significantly to the reparative fibroproliferative response by organization of hyaline membranes and reepithelialization of damaged septal walls.

Bronchi↗
PubMedDate not supplied

Correlative study of adult respiratory distress syndrome by light, scanning, and transmission electron microscopy.

The sequential pulmonary changes occurring in the evolution of adult respiratory distress syndrome (ARDS) were studied in 35 patients by correlative light, scanning, and transmission electron microscopy. The causes of ARDS were diverse, the major ones being sepsis or aspiration. Patient survival ranged from 3 to 51 days. The acute stage in patients surviving 2 to 7 days was characterized by an exudative reaction with a predominance of hyaline membranes. This acute stage merged with and was replaced by a subacute reparative stage in patients surviving 7 to 14 days, which in turn was replaced by a chronic fibroproliferative stage complicated by interstitial pulmonary fibrosis and a deranged acinar architecture. Correlation of findings by scanning electron microscopy with those by light and transmission electron microscopy provided an added dimension to understanding of the evolving stages of ARDS and demonstrated that type 2 pneumocytes contributed to the fibroproliferative stage through organization of hyaline membranes and re-epithelialization of alveoli.

Adolescent↗
PubMedDate not supplied

Practical aspects of competitive exclusion for the control of Salmonella in turkeys.

In laboratory trials, a fourth-passage culture of adult chicken cecal contents was protective against challenge with Salmonella typhimurium in turkey poults raised on wood-shavings poultry litter. The culture was not protective against pre-treatment exposure to hatchery-introduced S. bredeney and was inhibited in poults that had received an antibiotic injection at the hatchery. The inhibitory effect of the hatchery antibiotic could be avoided if the cecal-culture treatment was delayed by 3 to 4 days after antibiotic injection. Under field conditions, there was a significant reduction in the salmonella contamination of turkeys and their environment when cecal culture was given to poults raised on wood-shavings litter sprayed with a quaternary ammonium compound. When used alone, both the cecal culture and the litter disinfectant were ineffective in preventing the establishment of S. heidelberg infection. Further studies are required to confirm the possibility of a synergistic effect between the two treatments. For the control of salmonella in turkeys, use of cecal cultures may be limited by the interference of antibiotics and by their failure to protect against pretreatment exposure to salmonella.

Animals↗