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Biomedical subjects

W R Adey

Publications and source records attributed to W R Adey.

At least 73 records · Page 4Linked to original sources
PubMed1975

Modification of the direct cortical response by taurine.

The effects of taurine on the direct cortical response have been studied in immobilized cats (with local analgesia). The primary negative component of the response was inverted in polarity by the topical application of 25 mM taurine while the later slow negative component was considerably augmented. These effects are identical to those observed with 25 mM GABA. Pentobarbital anesthesia produced little qualitative change in the effects of taurine. With stronger stimuli in the presence of taurine, rhythmic waves followed each stimulus both at the cortical surface and at a depth of 1000 mum. An increase in the EEG amplitude following topical taurine was generally localized to the cortical surface but in certain experiments, could be recorded at cortical depths up to 1000 mum.

Animals↗
PubMed1975

Extracellular release of cerebral macromolecules during potassium- and low-calcium-induced seizures.

Cerebral cortex of cat was incubated with 14C-lysine and 3H-glucosamine. Subsequent superfusion of the surface of the cortex resulted in the release into the superfusate of a variety of 14C- and 3H-labeled compounds including proteins, glycoproteins, and gangliosides. The release of 14C- and 3H-labeled macromolecules could be considerably enhanced by topical addition of 40 mM K+, WHICH INDUCED Epileptiform EEG activity. Peaks in efflux could also be correlated with the onset of seizures induced by superfusion with low (0.75 mM) Ca2+ media. Control experiments in which the cortex was prelabeled with 14C-carboxyl-inulin and 3H2O indicate that the release of macromolecules was not a direct consequence of the altered blood flow that may occur during convulsions.

Animals↗