Biomedical subjects

W Pribadi

Publications and source records attributed to W Pribadi.

3 recordsLinked to original sources

PubMed1992

Seroepidemiological studies of malaria in different endemic areas of Indonesia.

A total of 618 sera from inhabitants living in various endemic areas in Indonesia were examined for IgG against Plasmodium falciparum utilizing young trophozoites and mature schizonts as antigens by the method of ELISA and IFAT. In general, antibodies against trophozites (RESA) based on ELISA and antibodies against schizonts based on IFAT showed a correlation of malarial antibodies with the level of endemicity of the area examined. Anti-RESA antibody, detected either by ELISA or IFAT was more pronounced in the aparasitemic group compared to the parasitemic group. On the contrary, anti-schizont antibody measured by IFAT was more pronounced in the parasitemic group. Malarial antibody levels against the schizont-merozoite fraction of P. falciparum as assayed by ELISA appeared to develop more slowly compared to levels based on IFAT.

Animals↗

PubMed1992

In vitro sensitivity of Plasmodium falciparum to chloroquine and other antimalarials in east Timor and east Kalimantan, Indonesia.

In Indonesia resistance of Plasmodium falciparum to chloroquine has spread to all provinces except Yogyakarta since the first report in 1974. The proportion of resistant cases is relatively low except in Irian Jaya and East Timor. The results of in vitro tests performed in East Timor showed 81.0% resistance to chloroquine, 87.5% to amodiaquine, 20.0% to sulfadoxine-pyrimethamine (S-P), 4.8% to mefloquine, and 100% sensitivity to quinine. The percentage of failures was between 11.1% and 71.4% and highest with the S-P combination. Multidrug resistance was observed in 9 cases (or 11.1%). The results of in vitro tests in East Kalimantan were: 62.8% resistance to chloroquine, 100% to amodiaquine, 85.7% to S-P combination, 3.2% to quinine, and 2.5% to mefloquine. Failures rates ranged between 21.2% and 37.1% the highest being with mefloquine. Multidrug resistance was more prominent and observed in 59 cases (84.3%) of which one case was resistant to 5 antimalarials, while 4 cases (5.7%) were resistant to chloroquine only, compared to 72 cases (88.9%) in East Timor.

Adolescent↗

PubMed1992

Decrease of malaria morbidity with community participation in central Java.

Malaria is still a problem in Java-Bali, although the Malaria Eradication Program started in the 1950's. In the First National Five Year Development Plan it was changed to the Malaria Control Program with the aim to reduce the morbidity and mortality rates through surveillance and spraying interventions using the primary health care approach. In 1984 in Central Java there were malaria areas with an average annual parasite incidence (API) between 1 and 7.5 promille covering about six million population, nearly one third of the population of Central Java. In this study an intervention alternative was carried out with weekly chloroquine prophylaxis to children below 10 years of age in 3 malaria areas of central Java, namely the villages Bedono Kluwung and Kalikutes in Purworejo Regency and Pablengan in Karang Anyar Regency. Health education about malaria with a learning module was conducted by key persons as an element of community participation. The activities of the key persons increased the ongoing surveillance. After one and a half years intervention (July 1985-February 1987) the spleen rates, parasite rates and fever cases dropped to nearly zero in the three study villages. From the results of this study it was recommended that in a malaria risk area with an API of more than 1 promille, intervention with collective chloroquine protection to children below 10 years of age could reduce the API to 1 promille or less. This intervention should be carried out if there is an increase of cases in the area to prevent small outbreaks.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗