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Biomedical subjects

W Plenert

Publications and source records attributed to W Plenert.

At least 91 records · Page 5Linked to original sources
PubMed1976

[Diagnostic and therapeutic aspects of leukoses in childhood].

30 TO 40% of all malignant neoformations in childhood are leukaemias. Within this group 80 to 85% of acute lymphatic leukaemias are found. The indicating signs (conditioned by the suppression of the normal myelopoiesis) are briefly described, differential diagnosies are only mentioned. Primary diagnostics and diagnostics of the course, the principles of remission induction and continuous therapy in leucaemia are sketchily described. Treatment of acute lymphatic leukaemia is performed adequate to the therapeutic scheme after Pinkel Prophylaxis of the central nervous system must be demanded. Modern therapeutic methods with the help of synchronisation and oncobiogramme are demonstrated. The possibilities of the symptomatic therapy in disease-conditioned and therapy-conditioned complications and side-effects occupy a somewhat broader space. Finally the principles of the organisation of the treatment of leukaemia in childhood are described.

Age Factors↗
PubMed1976

[Prerequisites and possibilities of immunotherapy in acute leukemias].

Nowadays there are references that immuno-reactions of patients with carcinoma against tumour-associated antigens are of essential significance for the development and progressing of tumours. Also the frequent appearance of neoplasms in primary immunodeficiency syndromes indicates this fact. Also in human leukaemias there exist leukaemia-associated antigens. Humoral as well as cell-bound immunoreactions may be proved. Possibly leukaemia-associated immunoglobulins are blocking factors which prevent the cellular immunoreactions against leukaemia-associated membrane antigens. The presence of specific reactions against antigens on leukaemia-cells was the condition for a successful immunotherapy. Despite many theoretical possibilities the immunotherapy in the clinic at present restricts to the BCG-vaccination and to the application of living or irradiated leukaemia-cells. The hitherto reported results are encouraging.

Acute Disease↗
PubMed1976

[Studies on the epidemiology of malignant tumors, systemic diseases and leukemia in children (author's transl)].

The analysis of statistical data on the incidence of leukemia in children in the German Democratic Republic between 1968 and 1973 gives no evidence for increasing risk of disease. Incidence in the G.D.R. is about the same as reported in literature. It seems that in the etiology and natural history of malignant tumors and hemoblastosis in children, constitutional and genetic as well as environmental factors are involved. They may work single or combined. Probably, malignant tumors or malignant systemic disease arise if the immune system fails to destroy endogenous or transplanted tumor cells.

Adolescent↗