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Biomedical subjects

W Pierpaoli

Publications and source records attributed to W Pierpaoli.

At least 73 records · Page 4Linked to original sources
PubMed1977

Role of host endocrine status in murine leukaemogenesis.

Permanent changes in the endocrine status of female SJL/J and CR mice were induced by masculinization, ablation of endocrine glands, inoculation of hormones, or feeding of the chemical carcinogen DMBA. All these procedures resulted in modification of the host hormonal milieu, as shown by blood hormone determination. Masculinization reduced drastically the onset of lymphosarcoma and increased the incidence of systemic neoplasms respectively in DMBA-treated female SJL/J and CR mice. Continued administration of gonadotrophins increased the incidence of systemic neoplasia in CR mice. A direct correlation is suggested between onset of lymphosarcoma or other tumours in mice and a specific shift to an abnormal hormonal environment.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1976

Interdependence of thymic and neuroendocrine functions in ontogeny.

The immunological blockade of the adenohypophysis of athymic nude mice bearing allogeneic skin grafts prevents the reconstitution of transplantation immunity when such animals grafted with thymus, and the grafts are permanently accepted. Newborn and adult athymic mice have markedly diminished levels of prolactin in blood and abnormally high levels of luteotropic hormone. Implantation of the thymus normalizes blood levels of these two hormones. These findings affirm the role of the thymus in the organization of the maturing brain for endocrine functions and identify prolactin as one of the hormones which play a major role in immune differentiation in early ontogeny.

Animals↗
PubMed1975

Failure of "thymus factor" to restore transplantation immunity in athymic mice.

Implantation of cell impermeable Millipore chambers containing thymuses from normal newborn donors into athymic mice does not confer on them the capability to reject allogeneic skin grafts. The same deficiency is manifested when skin grafted female nude mice are pregnant of foetuses with normal thymuses. These data are thus in sharp contrast to those previously reported for thymic factors reconstituting neonatally thymectomized mice.

Animals↗
PubMed1975

Inability of thymus cells from newborn donors to restore transplantation immunity in athymic mice.

Passive transfer of thymus cells from congenic donors to athymic mice reconstitutes the recipient's capacity to reject allogeneic skin grafts, provided the donor is immunologically mature and the number of thymus cells from the adult donor is high enough. Passive transfer of thymus cells from adult allogeneic donors induces a mild to severe graft-versus-host disease and the grafts are retained until death. These results are interpreted on the basis of recent findings on the endocrine conditions of congenitally athymic mice and on the previous data on the hormone dependence of thymus cells to acquire immunocompetence. It is proposed that a normal host environment is a prerequisite for the thymus-derived cells to perform in cell-mediated immune reactions.

Animals↗
PubMed1975

Role of the thymus in programming of neuroendocrine functions.

Specific derangements of thyroid and gonadal functions were observed in athymic nude and neonatally thymectomized mice. Such endocrine alterations are already established during the perinatal period and maintained through adult life. Passive transfer of lymphoid cells from normal donors does not prevent such alterations. In nude mice thymus implantation at birth fully reconstitutes oestrogenic function, but thyroid and progestational functions remain defective. Peripheral endocrine glands (thyroid, adrenals and ovaries) respond normally to ACTH, TSH and LH. Thus the thymus may well have a basic role in the organization of the adult hypothalamus-pituitary axis for thyroid and sexual functions.

Adrenal Glands↗