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Biomedical subjects

W P Wilson

Publications and source records attributed to W P Wilson.

At least 19 recordsLinked to original sources

Anterior temporal lobectomy for complex partial seizures: evaluation, results, and long-term follow-up in 100 cases.

We report evaluation and results in 100 patients who had undergone anterior temporal lobectomy for intractable complex partial seizures. Average follow-up was 9.0 years (range, 2 to 21 years). In the 2nd postoperative year, 63% were seizure free, 16% were significantly improved, and 21% were considered not significantly improved. Mean number of seizures in the last group was 27% of preoperative levels. Surgical results did not change significantly in subsequent postoperative years; good outcomes tended to persist over the longer term. We also examined the utility of continuous depth electrode monitoring in the evaluation of patients with independent bitemporal interictal epileptiform activity. Despite limited numbers of subjects in this category, there was a trend toward improved surgical outcome when such subjects were evaluated with depth electrodes.

Adolescent

Dioxins and dibenzofurans in blood and adipose tissue of Agent Orange-exposed Vietnam veterans and matched controls.

Vietnam veterans who were heavily exposed to Agent Orange exceeded matched control subjects in both blood and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) but not in the levels of the 12 other 2,3,7,8-substituted dioxins and dibenzofurans that were detected. Since only TCDD among these compounds was present in Agent Orange but all are present in the population of the industrialized world, it is likely that the elevated TCDD levels arose from wartime exposure. The high correlation (r = +.89) of blood with adipose tissue level suggests that there may be a mobile equilibrium between them and that blood measurement could replace adipose tissue measurement of TCDD levels, making the collection of human data less invasive.

2,4,5-Trichlorophenoxyacetic Acid

Ritual mourning for unresolved grief after abortion.

There is a popular consensus in the medical profession and the laity that spontaneous and induced abortions have few psychologic sequelae. A review of the literature reveals that this is not true; the incidence of symptoms ranges from 7% to 41%. Even when symptoms occur, they are said to be negated by the positive emotional responses that occur. We have accumulated clinical experience relating these experiences to the development of severe psychopathology that we believe arises out of unresolved grief. Abortions affect not only the women but also their "significant others." We present case reports that illustrate some of the sequelae, and we offer a method of treatment using spiritual intervention to resolve the grief.

Abortion, Induced

Religious life of individuals with affective disorders.

We inquired into aspects of the family history, the marital status, and the religious practices of groups of normal subjects and patients with affective disorders. Consistent with past findings in the literature, individuals with affective disorders came from homes where one parent was frequently missing. The affective disorders group did not differ significantly from control subjects in their adult religious behavior, but had shown significantly diminished religious interest during adolescence. We suggest that this sample of patients with affective disorders returned to religious commitment after adolescence. A possibly related finding is a higher rate of intact marriage and lower rates of separation and divorce among these patients, as well as upward social mobility.

Educational Status

Burnout and other stress syndromes.

Psychiatry has long recognized stress syndromes. The acute posttraumatic stress syndrome occurring in war is well known. Those occurring as a result of accidents in civilian life are less well known. Burnout is a recently described addition to this group of illnesses. The stress that is etiologic differs in many ways from that found in the acute syndromes. The stress that causes burnout is chronic, and is either self-imposed or inherent in a work situation. The illness responds to rest or removal from the work situation, but restructuring of the person's motivations and relationships is necessary if the person is to remain symptom free.

Adult

Assessing pathology in the separation-individuation process by an inventory. A preliminary report.

There is growing clinical evidence implicating disturbances in the separation-individuation phase of child development to adult psychopathology, particularly the borderline personality disorder. The clinical manifestations of such disturbance have been described by several clinicians and theoreticians. The authors have developed an inventory, based on these observations, designed to assess adult manifestations of disturbances in the separation-individuation process. The inventory was given to subjects meeting DSM-III criteria for borderline personality disorders and to a random university employee control group. The subject group had significantly higher scores than the control group. Although more research is needed to further establish the inventory's validity and reliability and to better define its scoring, the preliminary data indicate that it does assess adult manifestations of pathology in this developmental process.

Adult

Religious life of schizophrenics.

We inquired into the religious beliefs and practices of groups of schizophrenic and normal subjects. In addition, we evaluated their parents' methods of rearing the subjects. We found that, in the schizophrenic's home, the religious emphasis was limited and based on obligation and threat, and that the father had less of a religious commitment than the mother. Concerning personal development, the schizophrenic's mother was seen as more domineering than the emotionally and geographically absent father. The schizophrenic saw his religious and developmental upbringing as lacking in nurture and paternal participation. The schizophrenic himself seldom indulged in personal religious practices.

Adolescent

Religious life of narcotic addicts.

Because of the unstructured life-style of most narcotic addicts, we have inquired into the religious and social backgrounds and experiences of a group of narcotic addicts. It was observed that the subjects' parents were far less involved in religious practices than were a group of parents of nonaddicts. The addicts' fathers were found to be frequently absent from the home and uninvolved in the addicts' early religious training. The addicts came from broken homes and often their marriages also ended in divorce. The addicts, as compared to both their parents and the control subjects, were underachievers in both social and religious accomplishments.

Black or African American

Religious life of alcoholics.

It has been documented that alcoholics often become abstinent after a religious experience. We have inquired into the religious teachings, beliefs, practices, and experiences of a group of chronic alcoholics. It was observed that alcoholics were less involved in religious practices, had less exposure to religious teachings, had fewer religious experiences, and withdrew from religion more frequently during adolescence than did a group of normal subjects. It is concluded that early-life religious experiences of an alcoholic are most conflictual and lead to religious confusion rather than commitment.

Adult

The electroencephalogram in dementia.

The EEG in normal aging and in dementia due to a variety of diseases has been described. In dementia due to degenerative diseases, metabolic disorders, normal pressure hydrocephalus, and deficiency states, the diffuseness of the abnormalities observed has been emphasized; whereas with cerebrovascular disease and with intracranial massess, the focal nature of the changes has been stressed. Although a normal EEG does not rule out the diagnosis of dementia especially in its early stages, the EECG can nevertheless be a significant instrument in the identification or organic processes when the diagnosis is uncertain, in differentiating diffuse from focal cerebral lesions, and in following the course of the disease. Because electroencephalography is easily performed, is safe, and can be frequently repeated, it should be considered one of the more useful tools in the clinical evaluation of patients with dementia.

Aged