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Biomedical subjects

W P Fritsch

Publications and source records attributed to W P Fritsch.

At least 19 recordsLinked to original sources
PubMed1990

[Metastatic bile duct cancer in secondary biliary cirrhosis associated with primary sclerosing cholangitis in ulcerative colitis].

By means of a case-report of a 33 years old pat., having colitis ulcerosa for 16 years with serious epitheldysplasia and developing primary sclerosing cholangitis, the typical progress of the disease with manifestation of a secondary biliary cirrhosis is shown. The course was complicated by the development of a bile-duct carcinoma. Present possibilities of diagnosis and therapy are discussed.

Adenoma, Bile Duct↗
PubMed1987

[Methodologic studies of N-acetylneuraminic acid determination in human gastric juice].

Mucus protects the gastric mucous membrane from aggressive substances in the gastric juice. It consists of glycoproteins, the composition of which determines its ability of viscosity, adhesiveness, and cohesiveness. There is a special interest in sialic acids, which are found mostly in humans as N-acetylneuraminic acid (NANA). NANA is estimated by the thiobarbituric acid method. A special feature of this method is that only free sialic acids are estimated. A mild acid hydrolysis is necessary in order to measure the total NANA-content. Some conditions of the hydrolysis are investigated with respect to the special properties of the gastric juice. Hydrolysis sulfuric acid 0.01 mol/l results in an about 10% higher yield than hydrolysis with hydrochloric acid 0.01 mol/l. A maximal yield of hydrolysates is found when the gastric juice pH is adjusted to 2.0. After 45 minutes hydrolysis at 80 degrees C in a water bath there is for at least 60 minutes a constant NANA-concentration in the gastric juice samples. Human bile has no influence on the estimation with the thiobarbituric acid method. In regard to these conditions of hydrolysis pentagastrin (6 micrograms/kg KG s. c.) does not change the NANA-secretion over 60 minutes in patients with duodenal ulcer. During an intragastric bile salt infusion the NANA-output remains unchanged over 45 minutes.

Duodenal Ulcer↗
PubMed1985

[Secretin and bicarbonate secretion in probands and ulcer patients following bolus administration of hydrochloric acid into the duodenum].

Various amounts of hydrochloric acid (50, 100 and 200 ml) of two different concentrations (70- and 140 mmol/l) were rapidly instilled into the duodenum of eight healthy subjects and five duodenal ulcer patients. Secretin, gastrin and bicarbonate output were measured. Secretin release and bicarbonate secretion are dependent on acid load and not on acid concentration. There is a linear correlation between the amount of acid instilled into the duodenum and pancreatic bicarbonate output. After duodenal acidification duodenal ulcer patients released equal amounts of secretin and secreted as much bicarbonate as healthy subjects.

Adult↗
PubMed1983

[Preoperative diagnosis of intra-abdominal diseases. Reliability of sonography and computer tomography].

In a retrospective study the reliability of ultrasound and computed tomography was compared and evaluated using the subsequent intraoperative findings. The analysis comprised ultrasound and computed tomography data of 111 consecutive patients in whom both investigations were performed within one week and whose diagnoses could be ascertained intraoperatively within two weeks. The correct diagnosis was made preoperatively in 80 out of 111 patients by ultrasound (sensitivity 72%) and in 95 out of 111 patients by computed tomography (sensitivity 85%). The results show that computed tomography is superior to ultrasound in preoperative diagnosis of intraabdominal diseases (P less than 0.025). In particular, liver and adrenal tumours and diseases of the air-filled gastrointestinal tract can be diagnosed more reliably preoperatively by computed tomography than by ultrasound.

Adrenal Gland Diseases↗
PubMed1983

Extrahepatic bile ducts in healthy subjects, in patients with cholelithiasis, and in postcholecystectomy patients: a prospective ultrasonic study.

To determine the average diameter and the upper normal limit of the common bile duct in healthy man, 830 blood donors were examined by ultrasound. The mean diameter was 2.5 +/- 1.1 mm (SD) at the porta hepatis and 2.8 +/- 1.2 mm (SD) at the widest point, the regression coefficient between both diameters being r = 0.84. None of the healthy subjects had a diameter larger than 7 mm at any site, and in 95% of all subjects the diameters were less than 4 mm at both sites of measurement. The diameters were significantly correlated with age (r = 0.16) and weight (r = 0.11), but not with sex, height, and body surface area. In 73 patients with cholelithiasis and in 55 patients after cholecystectomy, all of whom lacked clinical or laboratory signs of biliary obstruction, the average diameters at the porta hepatis were 3.8 +/- 2.0 mm and 5.2 +/- 2.3 mm, and at the widest point 4.8 +/- 2.2 mm and 6.2 +/- 2.5 mm, respectively. It is concluded that a common bile duct with any sonographic diameter larger than 4 mm should be followed closely and evaluated further with clinical examinations such as intravenous cholangiography unless cholecystectomy has been performed.

Adolescent↗
PubMed1983

Sonographic measurements of the normal liver, spleen, pancreas, and portal vein.

Normal values and upper limits (95th percentile) of liver, spleen, pancreas, and portal vein size were determined prospectively with ultrasound in 915 healthy subjects. Sex, age, weight, height, and body surface area were determined in each case. Since correlation of longitudinal and transverse organ diameters with physical data was poor (r less than or equal to 0.3), the authors do not consider it necessary to correct the measurements accordingly. However, the liver is oriented longitudinally in slender subjects and transversely in heavy subjects; thus both longitudinal and anteroposterior diameters need to be measured, since the longitudinal diameter alone will give too high or too low a value, respectively.

Adolescent↗
PubMed1983

[Antacids in combination with other anti-ulcer agents].

Antacids should not be combined with other anti-ulcer drugs such as carbenoxolone, metoclopramide, domperidone, sulpiride, di-citrato-bis-muthate and alginic acid. The effect of each single drug can be negatively influenced by combined application. H2-receptor-antagonists and sucralfate seem to be useful in combination with antacids. There is no evidence up to now that goals of therapy can be attained more effectively and in a shorter time than with either a drug alone. Before pirenzepine will be given in combination with antacids, bioavailability of the drug should be proved during antacid treatment. Today antacids in combination with other antiulcer drugs cannot be recommended for routine ulcer therapy.

Aluminum↗