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Biomedical subjects

W P Fritsch

Publications and source records attributed to W P Fritsch.

At least 19 recordsLinked to original sources
PubMed1990

[Metastatic bile duct cancer in secondary biliary cirrhosis associated with primary sclerosing cholangitis in ulcerative colitis].

By means of a case-report of a 33 years old pat., having colitis ulcerosa for 16 years with serious epitheldysplasia and developing primary sclerosing cholangitis, the typical progress of the disease with manifestation of a secondary biliary cirrhosis is shown. The course was complicated by the development of a bile-duct carcinoma. Present possibilities of diagnosis and therapy are discussed.

Adenoma, Bile Duct↗
PubMed1979

[Long-term suppression of H+ secretion through a combination of cimetidine and methanthelinbromide (author's transl)].

Inhibition of acid secretion was investigated in 5 patients with Zollinger-Ellison syndrome and 12 patients with duodenal ulcer after administration of 200 mg cimetidine alone and combined with 50 mg methanthelinebromide. A preinvestigation of 5 patients had not shown any significant decrease of acid secretion after 50 mg methanthelinebromide alone. Compared with a single dose of 200 mg cimetidine, combined drugs' use (200 mg cimetidine and 50 mg methanthelinebromide) led to significant increase of inhibition of secretion both as regards degree and duration. In 6 patients with duodenal ulcer basal secretion of more than 2.0 mmol H+/h 200 mg cimetidine led to inhibition of secretion by 91.4% over 120 min compared to 96.4% over 225 min after combined administration. Similar results were obtained in 6 patients with a basal secretion of less than 2.0 mmol H+/h.

Adult↗
PubMed1979

[Anatomical distribution of a CCK-oktapeptide like substance in the human brain (author's transl)].

Using Gastrin 14-17 as immunogen it was possible to raise an antiserum, which showed a high sensitivity for the C-terminal octapeptide of CCK in a radioimmunoassay with 125J-gastrin as tracerhormon. High immuno-reactivity could be demonstrated in the grey and white matter of the human cortex as well as in the putamen and nucleus caudatus using this assay. By comparing the unknown brain substance with different peptides in different physico-chemical systems, the brain substance was shown to be homogenous and being similar to CCK-8.

Brain Chemistry↗
PubMed1979

[Vagotomy and serum gastrin levels (author's transl)].

Following selective proximal vagotomy (SPV) in duodenal ulcer patients basal acid output (BAO) and peak acid output (PAO) decrease by 79,3% and 41,8% respectively. Serum gastrin levels increase by 83% within the first five days after operation. Patients having had a SPV release evidently more gastrin after test meals as compared with the results before vagotomy. In consideration of the elevated praeoperative values insulin hypoglycaemia does not cause an augmented secretion of gastrin. There is no correlation between the fall in acid secretion and the increase in gastrin levels. Acidification of the gastric antrum (pH 2,0) did not influence the raised serum gastrin levels at the 10. day and one year after operation. There is a close correlation (r=0,94) between the percental increase in the basal gastrin concentration and the percental change of the vagal influence on the secretion of the parietal cell. It is postulated that together with the dissection of stimulating vagal fibres reaching the parietal cells other fibres are cut which cause an inhibition of gastrin release from the antral G-cells. Thus, the disinhibition of an oxyntopyloric reflex may account for the increase in serum gastrin levels after SPV.

Duodenal Ulcer↗
PubMed1978

[Gastrin].

Gastrin antisera were raised by immunization of rabbits or guinea pigs with synthetic human gastrin I conjugated to bovine serum albumin by carbodiimide. Radioiodination of SHG: 2-17 was performed by the chloramine T-method and by an enzymatic procedure. AE-cellulose was used to get a monoiodinated tracer hormone. Antibody reactions with the different forms of gastrin and with CCK-PZ was characterized. Precision (VK = 6-8%) and reproducibility (VK less than 15%) of the gastrin values were comparable to the insulin assay. Gastrin stimulates the parietal cell and has trophic effects on gastric mucosa. Hypergastrinaemia in combination with hypersecretion exhibits clinical significance in patients suffering from Zollinger-Ellison-syndrome or excluded antrum-syndrome which are due to autonomous gastrin release. Some findings suggest a pathogenetic role of gastrin in duodenal ulcer disease. Those disease in which gastrin determinations are of clinical value are discussed.

Animals↗
PubMed1977

[Treatment of peptic ulcer in the Zollinger-Ellison syndrome with histamine H2-receptor antagonists (author's transl)].

Histamine H2-receptor antagonists metiamide and cimetidine were used in the treatment of severe peptic ulceration in Zollinger-Ellison syndrome. The ulcerations were completely healed in all four patients after treatment lasting from six weeks to four-and-a-half-months. Two patients developed recurrent ulcer after the treatment had stopped, but responded to a second course. One patient developed hepatitis B during cimetidine treatment and it is possible that the course of the hepatitis was unfavourable affected by cimetidine. But no other side effects were noted nor was there a significant change in basal serum-gastrin concentration or an increase in H+ secretion. Total gastrectomy remains the treatment of choice in Zollinger-Ellison syndrome, but cimetidine should be considered if the patient refuses operation or operation is not feasible because of a poor general state.

Adult↗