Penetration of ciprofloxacin into human lung tissue following intravenous injection.
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Ciprofloxacin↗
Biomedical subjects
W Opferkuch
Publications and source records attributed to W Opferkuch.
Bile levels of imipenem in patients with T-drain following the administration of imipenem/cilastatin.
Twenty-four patients undergoing gall bladder surgery and placement of a Kehr T-tube were examined for imipenem pharmacokinetics in plasma and bile fluid following an intravenous short-term infusion (20 min) of 500 mg respectively 1000 mg each of imipenem and cilastatin. In group I (500 mg; 12 patients) a mean peak concentration in bile fluid of 10.5 mg/l (range 1.5 to 16.7 mg/l) was reached just after 10 min. 60 min after the end of infusion the imipenem concentration was between 8 and 9 mg/l. In group I the half-life of imipenem in bile was 0.84 h. In group II (1000 mg; 12 patients) the mean peak level in bile fluid was 1&.5 mg/l (range 3.5 to 51.3 mg/l). The half-life in bile was 1.24 h in this group. The data indicated that 4 h after the administration of either 1000 mg or 500 mg, imipenem serum and bile concentrations were markedly above the MIC values for pathogens expected to be found in infections of the biliary tract.
Aged↗
Influence of imipenem on the serum resistance of enterobacteriaceae.
Following growth in a subinhibitory concentration of imipenem and additional incubation in a 20% dilution of normal human serum (NHS) for 90 minutes, five of 12 serum-resistant strains of enterobacteriaceae showed a decrease in colony-forming units of two or more logs of growth compared with the control. Two strains (of Escherichia coli and Enterobacter aerogenes) showed this phenomenon even with incubation in 5% NHS. Treatment with imipenem did not change the serum resistance of the other seven strains (two strains each of Enterobacter cloacae, Klebsiella pneumonia, and Serratia marcescens, and one strain of Proteus morganii). The phenomenon of induced serum susceptibility is dose dependent and reversible. Other beta-lactam antibiotics either caused only a slight decrease of resistance (cefsulodin, cefoxitin, cefuroxime, cefodizime-HR221) or did not influence the serum resistance at all (cefotaxime, mecillinam). Killing of the induced serum-sensitive strains appeared to be antibody dependent.
Anti-Bacterial Agents↗