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Biomedical subjects

W Oehlert

Publications and source records attributed to W Oehlert.

At least 37 records · Page 2Linked to original sources
PubMed1979

Electron microscopic studies on the small intestine of rats after mechanical intestinal obstruction.

The morphologic changes of the small intestine after the mechanical obstruction were studied by light and electron microscopy. After the ligation of the upper small intestine, segments of jejunum, both proximal and distal to the site of obstruction, were removed at intervals varying from 45 min to 24 h. The essential changes were found in the epithelial cells of the tips of villi, and few morphologic differences were recognized between samples proximal and distal to the site of obstruction. The most remarkable changes in the mucosa were the pseudopodlike extension of the cytoplasm, vacuolar alteration of the villus epithelial cells, desquamation of these degenerated cells, and the dilatation of the epithelial intercellular spaces. A few epithelial cells showed hypertrophy of the smooth endoplasmic reticulum. In the submucosa, vascular stasis and edema were observed throughout the course. The mechanism of fluid loss into the intestinal lumen was discussed briefly.

Animals↗
PubMed1976

[Intrahepatic cholestasis due to N-propyl ajmaline].

In two patients intrahepatic cholestasis and cholestatic liver disease probably due to N-propyl ajmaline were observed. In both cases there was a four-week-interval between the first ingestion of the drug and the onset of jaundice. In one case with rigors there was a temporary rise in temperature and cholestasis. In the other there was a two to three week prodromal period of pruritus and gastro-intestinal symptoms. Both cases were characterised by blood and pronounced tissue eosinophilia in the periportal zones, a marked increase of cholestatic and hepatic cell enzymes, serum bilirubin and cholesterol, a moderate increase in erythrocyte sedimentation rate and absence of leucocytosis. Pathological laboratory findings returned to normal spontaneously within 5 weeks in one case and within two weeks under steroid therapy in the other.

Adult↗
PubMed1975

[Controlled study of the therapeutic effect of B vitamins and an anabolic steroid in chronic hepatitis (author's transl)].

In 66 patients with chronic active hepatitis and chronic fatty liver hepatitis of predominantly alcoholic aetiology the effect of B vitamins and the anabolic steroid clostebol (Steranabol) was tested during an eight-week period, using 12-biochemical parameters of liver function, histological findings and the activity of 14 enzymes. In chronic active hepatitis there was no demonstrable difference in effect between the treated and untreated subjects. In those with chronic fatty liver hepatitis, the marked greater therapeutic effect among the untreated group during hospitalization is thought to have been due largely to an accompanying reduction of alcohol intake.

Adult↗
PubMed1975

[Gastric mucosal dysplasias: what is their clinical significance (author's transl)].

Using criteria of proliferation kinetics, karyometry, histology and histochemistry, the attempt at a definition of normal and dysplastic surface epithelium of the gastric mucosa is made. Instead of using such terms as surface carcinoma, intra-epithelial carcinoma and carcinoma-in-situ, the term dysplasia III of the surface epithelium is suggested, because serial biopsies of gastric mucosa over periods ranging from one month to two years have demonstrated reversibility or persistence of such changes without transition into early carcinoma. Results of such studies in 8 262 patients demonstrate that even proliferation-kinetic, karyometric and histochemical methods do not make it possible to judge from single tests the prospective potency of certain changes of the gastric surface mucosa as "precancerous" or even "intra-epithelial carcinoma".

Carcinoma in Situ↗
PubMed1975

[Morphological effects of intraperitoneal oily fatty acids on the intestine and peritoneum of rats].

UNLABELLED: Changes of the mucosa of the small intestine in animal experiments can be produced by a variety of methods. The direct application of numerous chemical agents on the epithelium of the mucosa and parenteral administration of cytostatics as well as an indirect damage by experimental intestinal lymphatic obstruction lead to mucosal lesions with atrophy of the villi. Our paper presents a simple indirect method for induction of structural mucosa changes in rats using experimentally produced peritoneal alterations as a precursor. MATERIALS AND METHODS: The first experimental group with 108 male wistar rats was divided into 5 subgroups and treated as follows: 43 rats got continuous daily intraperitoneal injections of 3-3 ml/kg body weight sesame oil DAB 6 which contains 50% oleic acid, 36% linolic acid, 1% free fatty acids, 0.1% lecithin and portions of stearic, palmitic and arachic acid; 6 rats got 6.6 ml sesame oil per kg i.p., 43 animals received daily doses of 3-3 ml oil/kg per orally by a pharyngeal tube, 6 rats of each group were sacrificed after 68 and 92 days, all the rest were killed after 100 days of continuous daily treatment. Aortic blood was used for determination of the total cholesterol serum concentration. Blocks of tissue of every organ were fixed in 4% formalin, sections were stained with hematoxylin and eosin, hematoxylin-sudan and by the periodic acid Schiff (PAS-) method. For the purpose of autoradiographic determination of the 3H-thymidine labelling index the rats were administered i.p. 2 mCi 3H-thymidine/kg 40 minutes prior to death. Autoradiographs were prepared from sections of the small intestine by using liquid photoemulsion Ilford K5. In the second experimental group 7 rats got a single i.p. injection of 5 ml, 5 rats of the 10 ml and 9 rats of 20 ml sesame oil per animal; 4 rats were administered 8 ml daily for 5 days...

Animals↗
PubMed1975

[Toxicology of epidithio-dioxopiperazines. 1. Studies on toxicity of cyclosarcosylsarcosineepitetrasulfide in guinea pigs and rats].

The present paper deals with the toxic effect of a mycotoxin of the group of epidithio-dioxopiperazines: cyclo-sarcosyl-sarcosin-epitetrasulfide, particularly upon the liver of guinea-pigs and rats. The sporidesmines, related to the compound tested, cause chronic obstructive cholangitis characteristic of a disease in sheep endemic in New Zealand. This type of cholangitis was attempted to be reproduced in order to establish an experimental model of producing biliary cirrhosis in animals. The acute and subacute LD50 in rats and guinea-pigs were determined intraperitoneally and intragastrally. In neither mode of application nor in short-term nor in chronic test could we find any specific, dose dependent changes of bile ducts. Merely, parenteral administration of lethal doses led to unspecific subcapsular liver necroses obviously due to direct diffusion of the toxic agent. The discrepancy between the efficacy of the toxic grass in New Zealand and the substance tested in the study is discussed.

Administration, Oral↗