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Biomedical subjects

W O Chukwudebelu

Publications and source records attributed to W O Chukwudebelu.

5 recordsLinked to original sources
PubMed1980

The effect of chloroquine on strips of pregnant human myometrium.

We investigated the effect of chloroquine on the activity of strips of myometrium obtained at lower segment Caesarean sections from 150 patients. At concentrations below 1 X 10(-4) M, chloroquine did not affect the frequency, tonus or amplitude of contraction. At higher concentrations, it more than doubled the frequency of contractions in muscle strips showing spontaneous activity. In quiescent strips requiring stimulation by oxytocin, chloroquine had a generally depressant effect which could be overcome by higher doses of oxytocin. We suggest that chloroquine does not cause premature labour or abortions.

Chloroquine↗
PubMed1979

The incidence of hepatitis B surface antigen in Nigeria.

We have determined the incidence of hepatitis B surface antigen (HBsAg) in an urban (Enugu) and a rural (Okpatu) population groups in Nigeria. There were no statistically significant differences between the incidence in the two populations. Contrary to earlier reports we did not observe any significant age-related differences in the incidence rates within either population group. In general our results are similar to those reported for the urban inhabitants of Ibadan (several hundred miles west of Enugu) and its surrounding rural population. The low carrier rate recorded for schoolchildren drawn from a mainly high socio-economic group in our population has led us to suggest that socio-economic status alone or together with exposure to mosquito and other insect bites are probably the most relevant factors in the transmission of HBsAg in Nigerians.

Adolescent↗