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Biomedical subjects

W Nowak

Publications and source records attributed to W Nowak.

At least 91 records · Page 5Linked to original sources
PubMed1976

[Relations between portal and peripheral venous insulin, proinsulin and glucagon concentrations after oral glucose in man].

During cholecystectomy a catheter was inserted into the V. porta via V. umbilicalis. 7 or 8 days later an oral glucose tolerance test was performed (100 g). Blood glucose, insulin (IRI), proinsulin-like material (PLM), and pancreatic glucagon (IRG) concentrations were determined in portal as well as in peripheral venous blood. 5 out of 6 patients showed a disturbed carbohydrate tolerance in comparison to 53 healthy subjects. The IRI increased promptly after the oral glucose load. The portal IRI-concentrations are significantly enhanced in comparison to the peripheral levels, but between both a positive correlation exists (r = 0.9447; p less than 0.01). PLM was slightly increased in the first 10 minutes. The basal IRG levels were not enhanced. Significant differences between the portal and peripheral IRG concentrations could not be observed. The correlation coefficient was 0.8902. Thus, the peripheral venous concentrations of IRI, PLM and IRG can be used as a diagnostic tool of pancreatic hormone secretion in man.

Administration, Oral↗
PubMed1976

[Influence of vagotomy on glucose tolerance and on the responses of plasma insulin and exocrine pancreatic function followed glucose load or food ingestion in dogs].

A part of the intrapancreatic nerve fibres of dogs show 1-2 months after bilateral truncal vagotomy a decay of the medullary sheath; in addition, the histochemically demonstrable insulin content of the B-cells is reduced. These animals do no longer react to oral glucose administration or feeding a meat meal with a reflectoric early rise of plasma insulin concentration and of exocrine functional parameters (all the animals were bearing exocrine pancreas fistulas). The glucose tolerance and and the decrease of free fatty acids in serum were restricted. Also, the content of bicarbonate and protein in the pancreatic juice and the insulin secretion of vagotomized animals are strongly reduced in the subsequent test phase (up to 120 min) following oral or i.v. glucose administration and after feeding meat. The inhibition of exocrine volume secretion following i.v. glucose administration was enhanced by the intervention. The findings confirm the involvement of the N. vagus in the mechanisms of the enteroinsular axis that becomes active together with exocrine gastro- and duodenopancreatic reflexes to any kind of physiological enteral stimulation.

Animal Feed↗
PubMed1976

The mechanism of insulin secretion after oral glucose administration. VII. Exocrine pancreatic function and plasma-IRI in dogs with chronic pancreatic fistulas.

During an intravenous glucose test, conscious dogs with exocrine pancreatic fistulas showed a reduction in the secretions of water, protein and of bicarbonate. This reduction is related to hyperglycemia and to IRI increase in the peripheral venous blood. After oral administration of glucose, however, a biphasic stimulation of the exocrine function was observed. During the first 15 minutes when insulin secretion increases independently of the blood glucose increase, all exocrine pancreatic functions are transiently stimulated, too. A second peak of the exocrine secretions is to be observed when glucose absorption and insulin secretion exhibit their maximum.

Administration, Oral↗
PubMed1976

The mechanism of insulin secretion after oral glucose administration. VIII. Pancreatic juice insulin excretion after glucose loading and meal ingestion in normal and vagotomized dogs.

On pancreatic fistula dogs, in the pancreatic juice, immunoreactive insulin has been identified. Insulin excretion is shown to be inhibited by an intravenous glucose load and to be stimulated in a biphasic manner by an oral glucose load or by ingestion of mashed meat. Insulin excretion is reduced 2 months after bilateral truncular vagotomy and the reaction to both oral stimuli is abolished. -- There is no statistical correlation between pancreatic juice insulin and blood glucose, plasma IRI, or plasma amino nitrogen concentrations. Single extrainsular B-cells shown by histologic examination are suggested to be the source of pancreatic juice insulin. Compared to insulin secreted into the portal blood flow, insulin in the pancreatic juice amounts to only 0.1--0.2% of the daily secretory rate of the islets of Langerhans.

Administration, Oral↗
PubMed1976

[Bacteroides infection in surgical patients (author's transl)].

More than 80 cases of bacteroides infections are reported. 54 cases of these infections were postoperative complications. Relationships between bacteroides infection and diseases of the colon are significant. Not very impressive local symptoms made the diagnoses of abscesses difficult. In most cases bacteroides are susceptible to chloramphenicol and tetracycline. Patients develop agglutinable antibodies after bacteroides infection.

Adolescent↗
PubMed1975

[Correlations between human portal and peripheral venous insulin and proinsulin concentrations under glucose infusion].

In 8 female patients carbohydrate tolerance was proved by means of glucose infusion test 3 days after cholecystectomy. Parameters analyzed in portal and peripheral vein blood are compared with that of 47 healthy persons. All patients demonstrate a pathological carbohydrate tolerance after cholecystectomy, further characterized by an increased lipolysis, a paradoxical rise of HGH, a diminished insulin secretion during the early and increased IRI output in the second phase. There is a significant positive correlation between portal and peripheral vein IRI concentration despite the rising portalperipheral venous IRI difference with raised portal venous IRI concentration. Corresponding differences for proinsulin concentrations can be established in the early phase only. Relations existing between blood glucose and IRI are shown by multiple regression analysis. They suggest that the altitude of IRI concentration is determined by previous blood glucose concentration.

Adult↗