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Biomedical subjects

W N Morley

Publications and source records attributed to W N Morley.

At least 19 recordsLinked to original sources
PubMed1989

Familial properdin deficiency associated with chronic discoid lupus erythematosus.

A large family comprised of 18 members is described. Four male members are properdin-deficient, all are healthy bar the index patient who presented with chronic discoid lupus erythematosus. Serum from properdin-deficient males had a reduced ability to lyse rabbit erythrocytes via the alternative pathway or solubilize pre-formed immune complexes. Addition of purified properdin restored these activities. Classical pathway activity was normal. Definite, probable and possible female carriers had normal classical and alternative pathway activities.

Family↗
PubMed1987

An annular erythema of infancy.

An unusual annular and arciform erythema in an infant is reported. Skin lesions appeared when the child was 4 days old, and multiple lesions have been present during the subsequent two years. Individual lesions gradually enlarge over a period of a few weeks, and they resolve spontaneously without any residual cutaneous abnormality. This annular erythema is clinically and histologically distinct from previously described annular erythemas of infancy, with which it is compared.

Child, Preschool↗
PubMed1980

Studies on a new case of xeroderma pigmentosum (XP3BR) from complementation group G with cellular sensitivity to ionizing radiation.

XP3BR is a fibroblast strain derived from a xeroderma pigmentosum patient exhibiting severe mental retardation in addition to the typical changes in the skin. No tumours have been observed by 6 years of age. Cells from this patient had no detectable excision repair of u.v. damage. The defect in daughter strand repair was also characteristic of excision-defective XP's. The material was assigned to complementation group G and is the second (unrelated) example from this group. XP3BR cells were more sensitive than normal cells to the lethal action not only of u.v. but also of gamma irradiation, in contrast to all other XP cells tested to date including XP2BI, the other representative of complementation group G. The u.v. sensitivity was similar to that of strains from complementation groups A and D, confirming the correlation between extreme u.v. sensitivity and the presence of neurological defects. Following treatment with u.v., XP3BR, and other XPs gave more 6-thioguanine resistant mutants than normal cells whether the comparison was made per unit of dose or per lethal event. After low doses of gamma irradiation XP3BR cells were more mutable than normal or XP2BI cells.

Cell Line↗
PubMed1977

Body infestations.

The common body infestations, their incidence, diagnosis and treatment are discussed. Pediculosis capitis still has a high incidence in Britain. The louse could probably be effectively eradicated provided a national campaign of treatment and education were undertaken. Intensive therapy with a malathion containing preparation should be used before the louse develops resistance to this new organophosphorus insecticide. Similarly, scabies can be effectively treated. All doctors should be aware of the signs and symptoms of this common dermatosis and its treatment.

Adolescent↗
PubMed1976

Dermatitis herpetiformis in association with treated coeliac disease.

The paper describes an adult patient with coeliac disease who developed classical dermatitis herpetiformis while receiving a gluten-free diet. The dermatitis is controlled by sulphapyridine but relapses when this is withdrawn, even though the patient continues with the diet, indicating that a gluten-free diet plays little or no part in controlling the skin condition.

Adult↗