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Biomedical subjects

W N Jones

Publications and source records attributed to W N Jones.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Evaluation of various methods of digoxin dosing.

The ability to precisely predict serum digoxin concentrations using 12 published methods in a group of 85 patients was undertaken. Two methods of estimating creatinine clearance and two estimates of ideal body weight were employed as input variables using the 12 dosing methods. This resulted in 40 relationships from which correlation coefficients and linear regression constants were derived for predicted versus measured serum digoxin concentrations. The correlation coefficients between predicted and measured serum digoxin ranged from -0.393 to 0.389. Possible explanations for the low correlation coefficients are interpatient variability in the kinetics of digoxin, the small number of subjects used to generate some of the digoxin dosing methods, undetected patient noncompliance in the present study, the use of empirically derived dosing methods, and/or the use of rather homogeneous patient populations to develop a given method while this study is comprised of a heterogeneous group of patients. The methods studied tend to overpredict serum digoxin concentrations and therefore generally allow safe, first approximations for digoxin dosing.

Adult↗
PubMedDate not supplied

The use of wire mesh in total hip replacement surgery.

Metal mesh is helpful in relation to two complications of total hip replacement; namely, migration of the trochanter and fatigue fracture of the medial wall of the acetabulum. Mesh is applied over the greater trochanter in instances when the trochanter is excessively porotic and would crush as the wires are tightened. It is used to "recapture" the trochanter or trochanteric fragments if migration has occurred. The wires are then brought through the mesh and tied over the mesh, thus distributing the load widely across the porotic trochanter. The problem of a thin medial acetabular wall is dealt with by medially embedding a hemisphere of metal mesh in the methacrylate creating the effect of reinforced concrete. This increases the physical properties of the methacrylate and helps to distribute the load to the public, ischial and iliac portions of the socket. Potentially this approach will be useful in treating fatigue fractures of the medial acetabular wall after total hip replacement. Thirteen patients treated using chrome cobalt metal mesh in association with total hip replacement are presented.

Acetabulum↗
PubMedDate not supplied

Appropriateness of long-term cimetidine prescribing.

The appropriateness of long-term cimetidine prescribing was evaluated retrospectively in an outpatient pharmacy setting. Criteria defining the acceptable use of cimetidine for greater than 8 wk were established. The prescribing of long-term cimetidine was found inappropriate in 34 of 51 patients (67 percent). In 16 patients, the duration of full-dose therapy was excessive. Eighteen patients lacked an acceptable indication for cimetidine. The patients falling into the unacceptable category were prescribed cimetidine either by general internists or gastroenterologists in 33 of 34 cases. There were no clear reasons for this prescribing pattern. Eliminating inappropriate long-term use of cimetidine could avoid potential drug interactions and be cost-effective.

Adult↗