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Biomedical subjects

W Muntean

Publications and source records attributed to W Muntean.

At least 109 records · Page 6Linked to original sources
PubMed1981

[Biphasic splenic rupture in a hemophilic child (author's transl)].

This report describes a biphasic splenic rupture following trauma in a 12 1/2 years old boy with the severe form of hemophilia B. Immediately after the trauma the boy was treated with only one single dose of factor IX concentrate. He stayed free of symptoms for 9 days until finally severe abdominal bleeding occurred.

Child↗
PubMed1980

Reye's syndrome.

Explore the source record for details and available documents.

Acute Kidney Injury↗
PubMed1980

Haemostatic changes in tall girls treated with high doses of ethinyloestradiol.

Haemostasis was studied in 8 tall girls during treatment with high doses of synthetic oestrogens for a period of 1 to 28 months. The girls received 0.5 mg ethinyloestradiol daily from day 1 to day 25 and 15 mg norethisteron daily from day 21 to day 25. All were without clinical signs of thromboembolism. Factors of the prothrobmin complex were significantly elevated in the tall girls compared to healthy controls of the same age. Fibrinogen was also significantly elevated. Factor VIII-related antigen was significantly higher in the tall girls and the ratio between factor VIII activity and factor VIII-related antigen was significantly decreased in the tall girls, as compared to the controls. Thrombin time was significantly shortened. Tests of primary haemostasis showed an increased tendency for thrombocytes to adhere to glass and to aggregate spontaneously and after stimulation with ADP or collagen. Whether these in vitro signs of hypercoagulability indicate an enhanced risk of throbmoembolic complications in tall girls treated with high doses of oestrogens remains to be established. However, these girls should be watched carefully for clinical signs of throbmoembolic complications during treatment.

Adolescent↗
PubMed1980

Lupus anticoagulant after measles.

A 2 2/12 years old boy developed a "lupus anticoagulant" after measles. Fibrinogen concentration and activity of factors II, V, VII, VIII, IX, X, XI and XII were normal, but partial thromboplastin time and thromboplastin time were prolonged. Thrombin time was within the normal range. Mixing normal plasma with the patient's plasma immediately prolonged the partial thromboplastin time, and incubation of the sample did not increase the inhibition. The immunglobulin fraction prepared from the patient's plasma on DEAE-sephacel also prolonged the partial thromboplastin time in cross mixing experiments. The thrombocyte count and thrombocyte functions were normal. In spite of the pathological partial thromboplastin and thromboplastin times, surgery was performed without excessive bleeding during the operation and without delayed wound healing.

Blood Coagulation Disorders↗
PubMed1980

[Ketamine anesthesia for outpatient procedures in children (author's transl)].

Ketamine anesthesia was used in children to perform 200 outpatient procedures (mainly spinal taps, bone marrow aspirations and biopsies). Atropine was administered in advance and a ketamine dose of 1.8--2.0 mg/kg i.v. was sufficient in most instances. The general anesthesia allows calm and accurate performance of the necessary procedures. Ketamine can be used repeatedly and was preferred by the majority of children for subsequent procedures. The application of Diazepam (2 mg i.v. or 5 mg rectally) reduced unpleasant wake-up dreams in older children. The children were under close observation until consciousness was regained. They left the outpatient clinic attended by their parents approximately one hour after the procedure.

Adolescent↗
PubMed1980

[Haemostasis in premature and newborn babies (author's transl)].

The mechanisms involved in haemostasis develop early in gestational life. Vessel wall contractility, platelets and increasing activity of coagulation and fibrinolysis have been found as early as the tenth week of gestational age. The development is not completed at birth and lasts throughout the first year of life. Mainly impaired platelet function and lower activity of coagulation factors differ from findings in older children and adults. Despite these in vitro differences, mature newborn babies appear to have a well functioning haemostasis.

Blood Coagulation Factors↗
PubMed1979

Immunologic studies of prothrombin in newborns.

Prothrombin of newborns was investigated by means of the quantitative immunoelectrophoresis and the two-dimensional immunoelectrophoresis. The plasma of 10 of 24 healthy term newborns and of 5 preterm infants taken immediately after birth showed one prothrombin precipitate in the alpha-2-beta-globulin position when a buffer containing 25 mM calcium lactate was used. No differences in the mobility and form of the precipitate could be observed as compared to healthy adults. The plasma of the other 14 term newborns and one small-for-date infant showed two precipitates, one in the alpha-2-beta-globulin position and a second in the alpha-1-globulin position. Twenty-four hr after the injection of vitamin K, the precipitate in alpha-1-globulin position was no longer evident. When a buffer without calcium was used in the two-dimensional immunoelectrophoresis, only one precipitate in the alpha-1-globulin position was found in all newborns. In the quantitative immunologic determination, the prothrombin was found to be decreased as compared to that of adults. The quantitative immunologic determination and the activity assay gave equal results in those infants who had only one precipitate in the two dimensional immunoelectrophoresis. In those newborns, who had two precipitates, the quantitative immunologic determination gave higher results than the measurement of the activity assay. From this study, no evidence of differences between the prothrombin of newborns and that of adults could be derived. Vitamin K deficiency, as judged from the appearance of a second peak in alpha-1-globulin position in the two dimensional immunoelectrophoresis was a frequent findings in term newborns, even on the 1st day of life.

Adult↗
PubMed1979

[Loss of inhibitors of the blood coagulation system in protein-losing enteropathy (author's transl)].

The investigation of the haemostasis of a 11 6/12 years old boy with protein-losing enteropathy revealed signs of hypercoagulability of the coagulation system, due to a decreased plasma concentration of antithrombin III and alpha1-antitrypsin, that were lost with other proteins in great amounts into the intestinal tract. The loss of these two important inhibitors of the coagulation system can lead to thrombotic complications in patients with protein losing enteropathy.

Antithrombin III↗
PubMed1979

[Thrombasthenia in a newborn (author's transl)].

Thrombasthenia is an extemely rare hereditary disorder of platelet function characterized by impairment of adhesiveness, ADP-induced aggregation, and clot retraction. Petechiae and ecchymoses in a newborn infant followed by prolonged jaundice facilitated early diagnosis.

Blood Coagulation Factors↗
PubMed1978

[Recognition of bacterial infections in newborns by measuring specific antibody-titres (author's transl)].

Antibodies were measured in 172 unselected neonates against mixed polyvalent antigens derived from E. COLI, Klebsiella, Ps. aeruginosa and Proteus spp. respectively, using a modification of the indirect haemagglutination technique according to Neter. 120 of these neonates with no evidence of infection served as controls. 6 out of 8 children with proven E. coli septicaemia had either raised titres or significant rises in titre. Five further neonates with septicaemia, four due to Klebsiella and one to Pseudomonas, had pathologically raised titres as well. 8 out of 12 neonates with clinically suspected septicaemia in whom no pathogen was isolated from the blood or cerebrospinal fluid had raised antibody titres. Following premature rupture of the membranes 2 out of 3 neonates who subsequently developed proven E. coli septicaemia had raised antibody titres against E. coli even on the first day of life. These results suggest that the measurement of antibody titres can be a valuable aid to the diagnosis of neonatal septicaemia.

Antibodies, Bacterial↗
PubMed1978

[Hemostasis in hereditary hemorrhagic telangiectasia (author's transl)].

The investigation of a girl aged 8 with hereditary hemorrhagic telangiectasia showed an abnormality of primary hemostasis. The bleeding time was at the upper end of normal and platelet adhesiveness was decreased to a variable extent. Platelet life span was shortened, presumably due to the telangiectatic lesions typical of this disease. Platelet aggregation and ADP-content were normal as was the plasma coagulation system.

Blood Coagulation↗