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Biomedical subjects

W Moll

Publications and source records attributed to W Moll.

At least 55 records · Page 3Linked to original sources
PubMed1974

Facilitated diffusion of CO2 across albumin solutions.

The steady-state CO(2) flux across thin layers of 30 g/100 ml albumin solutions was measured in two different CO(2) partial pressure ranges (boundary PCO(2) values 3 and 8 torr, and 160 and 650 torr, respectively). From the data the apparent diffusion coefficient for CO(2), DCO(2), was calculated. In the high PCO(2) range a value of DCO(2) was found which is to be expected on the basis of diffusion of dissolved CO(2) only. In the low PCO(2) range DCO(2) was about 100% higher than in the high PCO(2) range, when carbonic anhydrase was present and the pH was approximately 7.7. DCO(2) depended on the concentration of carbonic anhydrase. It increased with increasing pH. It is concluded that an additional diffusion of bound CO(2) (facilitated CO(2) diffusion) occurs in the low PCO(2) range and that this transport involves the hydration of CO(2). From the diffusion coefficients in the two PCO(2) ranges the rate of facilitated diffusion was determined. Approximate calculations show that this rate (at pH </= 7.7) can be explained on the basis of the proposed mechanism of facilitated CO(2) diffusion: bicarbonate diffusion and simultaneous proton transport by albumin diffusion. The view that facilitated CO(2) diffusion is mediated by the diffusion of albumin is supported by the experimental finding of a considerable suppression of the facilitated CO(2) flux in the presence of gelatinized agar-agar.

Acetazolamide↗
PubMed1974

MEDLINE evaluation study.

MEDLINE (MEDLARS-ON-LINE) is the new on-line, interactive bibliographic searching system which was recently developed by the National Library of Medicine. The system provides users with lists of bibliographical citations and other information from a three-year file of over 1,250 biomedical journals. A survey testing user reactions was conducted at the University of Virginia Medical Library. The results of the survey are based on replies by 246 users who requested one or more MEDLINE searches between September 1972 and March 1973. The findings indicate that over 93% believe that MEDLINE is a substantial improvement over the traditional methods of searching through the printed indexes. These respondents also stated that the results of MEDLINE searches had assisted them in their clinical or research work, or both. Asked whether they would continue to use MEDLINE after the imposition of user charges on July 1, 1973, about 75% said that they would. The remaining 25% expressed some reservations and doubts. The survey gives reason to believe that with the imposition of user charges the use of MEDLINE will decline.

Information Systems↗
PubMed1972

Observations on the AIM-TWX service at the University of Virginia Medical Library.

This paper is an analysis of 100 short questionaires which were completed by patrons of the AIM-TWX computerized, on-line bibliographical search service at the Medical Library of the University of Virginia during the period from August 1971 to January 1972. The survey indicates strengths and weaknesses of the new system.

Computers↗