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Biomedical subjects

W Miller

Publications and source records attributed to W Miller.

287 records · Page 16Linked to original sources
PubMedDate not supplied

Eosinophilic heart disease presenting with features suggesting hypertrophic obstructive cardiomyopathy.

We report a 25-year-old female with characteristic features of eosinophilic heart disease on clinical presentation, echocardiography, cardiac catheterization, and LV endomyocardial biopsy. Concomitant physical examination and echocardiographic findings suggesting hypertrophic obstructive cardiomyopathy resolved during treatment with anticoagulation and prednisone therapy.

Adult↗
PubMedDate not supplied

Absence of a relationship of size of primary colon carcinoma with metastasis and survival.

This retrospective study analysed the relationship of tumor size to regional and systemic metastasis and to survival according to stage of disease. Colon cancers (391 cases) that were treated surgically at M. D. Anderson Hospital from 1955 to 1975 were reviewed. Staging of disease was based on the Astler-Coller modification of Dukes' staging classification. The mean diameters (cm +/- s.e.m.) of Dukes' B1, B2, C2 and D tumors were 4.47 +/- 0.34 (n = 46), 6.61 +/- 0.29 (n = 147), 5.39 +/- 0.23 (n = 71) and 5.78 +/- 0.24 (n = 120), respectively. The mean diameter of Dukes' B2 tumors was significantly greater than C2 (P less than 0.001) and D (P less than 0.05) tumors. Within stage B and C, size of the primary tumor showed no relationship to five year adjusted survival. Our findings suggest that colon carcinoma metastasis and survival are independent of tumor size. Because tumor burden does not account for distant disease, specific tumor cell phenotypes and biological processes are probably more important in determining metastatic disease.

Colonic Neoplasms↗
PubMedDate not supplied

A greedy algorithm for aligning DNA sequences.

For aligning DNA sequences that differ only by sequencing errors, or by equivalent errors from other sources, a greedy algorithm can be much faster than traditional dynamic programming approaches and yet produce an alignment that is guaranteed to be theoretically optimal. We introduce a new greedy alignment algorithm with particularly good performance and show that it computes the same alignment as does a certain dynamic programming algorithm, while executing over 10 times faster on appropriate data. An implementation of this algorithm is currently used in a program that assembles the UniGene database at the National Center for Biotechnology Information.

Algorithms↗
PubMedDate not supplied

Winnowing sequences from a database search.

In database searches for sequence similarity, matches to a distinct sequence region (e.g., protein domain) are frequently obscured by numerous matches to another region of the same sequence. In order to cope with this problem, algorithms are developed to discard redundant matches. One model for this problem begins with a list of intervals, each with an associated score; each interval gives the range of positions in the query sequence that align to a database sequence, and the score is that of the alignment. If interval I is contained in interval J, and I's score is less than J's, then I is said to be dominated by J. The problem is then to identify each interval that is dominated by at least K other intervals, where K is a given level of "tolerable redundancy." An algorithm is developed to solve the problem in O(N log N) time and O(N*) space, where N is the number of intervals and N* is a precisely defined value that never exceeds N and is frequently much smaller. This criterion for discarding database hits has been implemented in the Blast program, as illustrated herein with examples. Several variations and extensions of this approach are also described.

Algorithms↗
PubMedDate not supplied

Computed tomography of bronchial carcinoid.

Computed tomography was used to evaluate three patients with endobronchial tumors. In each case the mass showed enhancement following intravenous contrast medium administration. Each patient underwent surgical resection, and pathology showed carcinoid tumor in each case.

Aged↗
PubMedDate not supplied

MR findings on primitive neuroectodermal tumors.

Primitive neuroectodermal tumors (PNETs) are highly cellular primitive CNS neoplasms that resemble microscopically the undifferentiated cells of the germinal matrix of the primitive neural tube. These tumors exhibit a highly malignant behavior with a tendency to disseminate along the CSF pathways. Previous descriptions of the neuroradiological findings in patients with PNET were published prior to the clinical application of magnetic resonance (MR) imaging. We describe our experience with the MR evaluation of four patients with pathologically proven PNET.

Brain↗
PubMedDate not supplied

Aorto-coronary graft for dissected coronary artery.

A 46-year-old woman while undergoing selective coronary cine angiogram dissected her coronary artery. She was managed by heparin therapy followed by urgent aorto-coronary artery saphenous vein graft with no consequences.

Cineangiography↗
PubMedDate not supplied

First report of intramyocardial pH in man: I. Methodology and initial results.

Continuous in vivo measurements of intramyocardial pH (MpH) have not been previously obtained in man. To achieve this goal, we developed in our laboratory a new, steel-jacketed, glass electrode, and circumvented temperature-related problems by recording the output in millivolts along with the adjacent myocardial temperature. A computer program was devised to calculate MpH in accordance with the Nernst equation. The need in this system for a remote, subcutaneous, reference electrode prompted two sets of experiments. The first set of experiments demonstrated in vitro that the adverse effect of varying the temperature of the reference electrode on the calibration of the pH electrode could be avoided if the reference electrode was placed in a potassium chloride (KCl) solution outside the body and connected to the subcutaneous tissues with a salt bridge. The second set of experiments, which were conducted in vivo in dogs, demonstrated that MpH measurements made with the reference electrode in the limb were not affected by ischemic electrocardiographic changes. This system was then used successfully in 10 patients undergoing coronary artery bypass surgery. Reliable, reproducible, and uniform changes were observed. Baseline MpH prior to revascularization was 6.81 +/- 0.07. Myocardial protection with cold K+ cardioplegia resulted in a significant rise in MpH to 7.45 +/- 0.06. Throughout the period of cross-clamping, MpH remained high. After revascularization and discontinuation of cardiopulmonary bypass, MpH stabilized at 6.93 +/- 0.04.(ABSTRACT TRUNCATED AT 250 WORDS)

Acid-Base Equilibrium↗