[Primary squamous cell carcinoma of the vagina following reconstruction operation (author's transl)].
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Biomedical subjects
Publications and source records attributed to W Michalica.
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We report 24 cases of sarcoma of the corpus uteri treated by sole irradiation. The 5-year-survival-rate was 20,8%. The prognosis seems to be poor in this group treated by sole irradiation. Only inoperable cases of sarcoma of the corpus uteri ought to be treated by radiotherapy alone.
The endogenous oestrogen state in 52 women (33 with endometrial carcinoma and 19 with benign conditions of the endometrium) was assessed ny means of histological examinations of vaginal swabs and of radio-immunological determinations of 17 beta-oestradiol. Considering their age, these women displayed an oestrogen activity far exceeding that found in previous studies. There was no difference between the oestrogen levels in women with carcinoma and the other patients. Furthermore, it was stiking that in the same group of women the examined parameters frequently showed different results. Consequently, a diagnosis based solely on the investigation of one parameter must frequently be misleading.
The method of choice for stimulation is extracorporeal radiotherapy of the blood, which has undergone stepwise clinical experimental development, is recommended. Implementation of this method induces a marked increase in the biosynthesis of certain serum proteins, especially the IgM and IgG fractions of the gammaglobulins and there is a definite tendency to normalization of certain serum enzymes in patients with cervical carcinoma. The dose dependence observed in the present study and the good clinical tolerance shown to this radiotherapeutic procedure are emphasized. The investigation is concluded with a cautions appraisal of the possible mode of action of extracorporeal X ray-irradiation of the blood at a dosage of 5000 R/O.
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This paper first reviews the relatively abundant literature on crystallization phenomena in human secretions, then our experiments, aimed at artificial imitation, are discussed. Threadlike crystals appear when the inorganic share of the solution shows 530mg% NaCl and 70mg% KCl and the organic one either 34mg% hyaluronic acid or 200 to 500mg% glucose. By overstepping the concentration limit of glucose or human albumin, crystallization can be prevented. The prevention of crystallization by proteins might gain some significance in diagnostic cytology as a primitive method to analyse colloid semiquantitatively.
A report is given on the excretion of variation of-aminolaevulinic acid (ALA) as an index of the lead load in pregnant women at term and at one and also at four weeks after delivery in both mothers and the newborn infants. The mean values in women were 7.2 + 3.7 before delivery 9.0 + 4.1 one week and 4.1mg ALA/1 urine four weeks after delivery; mean values of 5.2 + 3.2 one week after birth and 2.2 + 1.0 mg ALA/1 urine four weeks after birth were recorded in the newborn infants, according to the method of Davis and Andelman. Two groups were set up: mothers coming from the rural environs of Vienna and mothers living in the centre of the city. The ALA excretion was 14% lower in the former group (20% four weeks post partum) as compared with the mothers living in the city. When these data are considered against a threshold value of 10 ALA/1 urine (set up by the "Hauptverband der Berufsgenossenschafen", Bonn, West Germany, using the same method) the mean value of 9.0mg ALA/1 urine (with individual values of up to 17.4mg ALA/1 urine) in mothers one week after delivery already seems extremely serious.
A historical review is presented of the foundation of the radium ward of the 1st Gynaecology Department of the University and its development into the Radiotherapy Department of the 1st and 2nd Gynaecology Departments of Vienna University. Altogether 8500 patients with gynaecological carcinomas were treated primarily by irradiation over this period and 75.000 post irradiation outpatient follow-up examinations were carried through. This report includes laudatory statements by Prof. Antoine, Prof. Gitsch and Prof. Kärcher on the 25th anniversary of the department.
The cases of 627 women with gynaecological malignomas, who were primarily irradiated in 1967 to 1969, were interpreted, questioning the temporary difference between clinical and histological diagnosis and beginning of treatment with regard to five-years' healing-results and mortality. The study has demonstrated, that - a delay of only four weeks considered - the part of living patients waas 11,28% of the total number of living patients, the part of dead patients however was 21,62% of the total number of dead patients. We emphasize therefore the urgency of an immediate beginning of therapy following a reliable diagnosis.
In a further series of experiments, the same effect was found with cobalt-60-treatment as with X-ray-irradiation: the data determined by means of iodin-bromine-consumption in the methanolic serum-extract showed the same changes under equal exterior conditions at three different points of time. Corresponding to a diminished average dose of the cobalt-60-teletherapy, the humorally realized shock-reaction was reduced.
A report is given of an increase in urinary delta-aminolaevulinic acid (ALA) excretion in patients with cervical carcinoma treated by extracorporeal radiotherapy as well as with radium and telecobalt. It was found, that 16 out of 17 patients showed an increase of 125% (on average) in the elimination of ALA on the seventh day after irradiation. A return to noraml ALA-values was found in nine patients 42 days after radiotherapy whilst in six patients a further increase in ALA elimination occurred in comparison with the values recorded on the seventh post-irradiation day. The possible causes of the lead elimination, indicated by the ALA test, as well as the possibility of lead as an aetiological factor in tumour genesis are discussed.
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