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Biomedical subjects

W Mengel

Publications and source records attributed to W Mengel.

15 recordsLinked to original sources
PubMed1991

Total pancreatectomy in a case of nesidioblastosis due to persisting hyperinsulinism following subtotal pancreatectomy.

Hypoglycemia with hyperinsulinism persisted in a newborn weighing 6410 g despite treatment with high doses of diazoxide and glucagon, as well as infusions of glucose and somatostatin. A subtotal pancreatectomy was performed after nesidioblastosis had been diagnosed on the basis of the laboratory findings. Due to the persistence of therapy-resistant hypoglycemia, a total pancreatectomy preserving the duodenum and the bile duct was done 6 weeks later. With insulin and pancreatic enzyme substitution the now 6-year, 9-month-old child has shown normal, age, appropriate development.

Female↗
PubMed1991

[Cystic space occupying lesion of the upper pole of the kidney in a newborn infant. Case report and differential diagnosis].

In a newborn female infant a cystic lesion in the upper pole of the right kidney was detected by sonography 4 weeks before an uneventful delivery. In the postnatal period the sonographic examination, IVP, CT, and the biochemical data as well were not able to classify definitely this lesion as a benign cyst, adrenal hemorrhage or cystic malignoma. Therefore a laparatomy was performed, which revealed a cystic neuroblastoma.

Diagnosis, Differential↗
PubMed1990

Small bowel transplantation: report of a clinical case.

Extensive small bowel resection may become necessary for several reasons in children and adults. The only causal therapy of short bowel syndrome is small bowel transplantation. So far severe immunological problems have caused deleterious results despite technically successful transplantation. A clinical case of small bowel transplantation in a child is reported. The 3-year-old boy had been operated on for volvulus which had led to nearly total gangrene of the whole small bowel. Finally, only 4 cm of jejunum could be saved. Total parenteral nutrition (TPN) therefore became necessary. Small bowel transplantation was carried out with the mother as donor; transplantation technique is described in detail. Postoperative immunosuppression was performed by administration of cyclosporin A and prednisolone. Because of graft rejection, the graft had to be removed on the 12th postoperative day. At present, the child is well and on TPN again. This case shows that small bowel transplantation by living related organ donation is technically possible without impairment of the donor's quality of life. Further experimental and clinical work should be encouraged.

Child, Preschool↗
PubMed1990

Deep anterior resection with circular stapled anastomosis of congenital megacolon: clinical results.

This report deals with instrumental suture in the deep anterior rectum resection when treating Hirschsprung's disease. The concept includes: ensuring diagnosis, cleaning the intestines, antibiotic prophylaxis, intraoperative testing of the anastomosis and postoperative X-ray by a standardized technique. Our first experience in the use of the stapler was gained with ten patients. One case of anastomosis insufficiency occurred. With the stapler apparatus, safe anastomosis was possible. The stapler facilitates anastomoses in deep resections. Therefore, a deep resection of the pathological segment in Hirschsprung's disease is possible. The practicality of the stapler and the favourable clinical experience justify the continued application of the instrumental suture technique in children's surgery.

Anastomosis, Surgical↗
PubMed1990

Treatment of achalasia by the endoscopic-pneumatic dilatation method.

There is no definite cure for the loss of oesophageal peristalsis and incomplete relaxation of the lower oesophageal sphincter associated with achalasia. Pneumatic dilatation is a simple and safe method of achieving symptomatic improvement of the oesophageal passage. By this means five young patients became free of complaints within an average observation period of 6 3/4 years.

Adolescent↗
PubMed1987

[Psychological and cosmetic indications for the surgery of funnel chest].

From 1980-1983 the funnel chest of 29 patients (age range 6-40 years) was surgically corrected using Ravitch's method. In 25 patients clinical and cosmetic follow-up investigations were possible. The psychological investigation consisted of standardised interviews with special questions concerning the problems that patients with funnel chest have to deal with. In 16 cases the result of the operation was good, in 7 cases satisfying, 2 patients had a poor result. The presence of a funnel chest did have a psychological impact on most of the patients, who were inhibited in their psychosocial activities. Surgical correction changed these restrictions in most of the patients in a positive way. We conclude that the psychosocial indication for surgical correction of the funnel chest is justified, since our results strongly support this indication.

Adolescent↗
PubMed1978

Predicting school failure from information available at birth.

Information available from birth certificates was used to predict the psychological and educational status of approximately 1,000 randomly sampled first-grade children. The purpose of the research was to explore the feasibility of using birth certificate information as a cost-effective mechanism to identify children who were likely to need special educational services at public school entry. Multiple-regression and discriminant-function analyses revealed the following factors to be important in predicting psychoeducational status: birth order, race, educational status of the mother, month prenatal care began, survivorship of older siblings, and the child's legitimacy.

Achievement↗
PubMed1977

Cryptorchism.

Our results from 121 patients as well as data from the literature prove that fertility rates after treatment of uni- or bilateral cryptorchism remain unsatisfactory. There is no statistically significant difference in fertility between a group of patients treated with human-chorionic-gonadotrophin and another group treated by orchidopexy after unsuccessful hormonal therapy. On the other hand, late results in unilateral cryptorchism are to a statistically significant extent better than in bilateral cryptorchism (46/29%). According to our histological findings in maldescended testicles, early treatment (before the age of 3 years) is advocated.

Age Factors↗
PubMed1976

[Morphologic changes in cryptorchism (author's transl)].

Histologic changes caused by malposition occur in the undescended testicle after the second year of life. Histologic changes like those seen in the human are found in experimental cryptorchism in dogs. The same pathologic changes also occur in the unilaterally descended testicle. The results of preliminary experiments in dogs allow the statement that in unilateral cryptorchism the damage to the contralateral, descended, testicle is produced by an autoimmunologic mechanism.

Animals↗