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Biomedical subjects

W Meng

Publications and source records attributed to W Meng.

At least 109 records · Page 6Linked to original sources
PubMed1987

[Results of thyrostatic therapy of hyperthyroidism in patients with Basedow's disease and disseminated autonomy].

Up to now the results of drug treatment are unsatisfying. Treatment of more than 1-2 years did not decrease the occurrence of relapses. Thyroid suppression test and TRH test give the same indications concerning the outcome in cases with Graves' disease and disseminated autonomy (short-time prognosis). The relapse rate is distinctly higher in Graves' disease than in cases with disseminated autonomy (goitre class 3 excluded).

Follow-Up Studies↗
PubMed1986

[Status of goiter prevention in East Germany from an interdisciplinary viewpoint].

The endemic goiter occurs still in many countries of Europe. Alimentary iodine deficiency could be proved as essential cause of the increased prevalence. Comprehensive epidemiological investigations refer to the medical importance of this appearance for the GDR. 200 million marks might have to be spent annually for diagnostics and therapy. Also in the production of animals sequelae of iodine deficiency play a great part. Nitrate containing and glucosinolate containing feeding stuffs (e. g. rape extraction groats) here under the conditions of the iodine deficiency additionally develop goitrogenous effects (so-called indirect or relative iodine deficiency), which lead to decrease in vitality and clinical symptoms in the agricultural useful animals cattle, pig and sheep. The iodine content of animal products was frequently low. In view of the ecological connection of these problems an interdisciplinary iodine commission was founded which in accordance with the responsible state organs elaborates adequate recommendations for the prophylaxis and control of efficiency. From 1986 was begun with the iodisation of the largest part of packet salt (32 mg KJO3/kg) und the delivery of iodized mineral mixtures for the production of animals. Thus is to be reckoned with an improved direct supply of iodine for the population by iodized table salt or an indirect one over animal product. The iodisation of the entire common salt with modified iodine concentration is striven for. Measures for the control of efficiency are introduced.

Animals↗
PubMed1986

[Prolactinoma in the male].

In a retrospective study the medical records of 13 male patients with macroprolactinomas were evaluated concerning anamnestic data, clinical, endocrinological and localisation-diagnostic findings as well as therapeutic measures. The main symptoms were disturbances of vision and impaired potency and impaired libido, respectively. The ophthalmological complaints nearly exclusively caused the patients to see the doctor. Clinically the signs of hypogonadism were found. The diagnosis was ascertained by increased serum prolactin levels, ophthalmological findings, X-ray of the sella, cranial computed tomography as well as angiography of the carotid. The operative treatment did not show any normalization of the serum prolactin levels. The rate of recidivations after exclusive operative treatment was high. An additional medicamentous therapy with dopamine agonists is nearly always necessary after operation. Whether or not bromocriptine shall be used as primary therapy, must be decided on in the individual case.

Adolescent↗
PubMed1986

Thyroid status during pregnancy and post partum in regions of iodine deficiency and endemic goiter.

During pregnancy the thyroid is subjected to increased demands which is associated with a tendency to endogenous iodine deficiency. Under the conditions of insufficient iodine supply in the GDR the pathophysiological changes result in: 1. prevalence of goiter in about 60% of pregnant women; 2. enlargement of the extent of neck in more than 50% of all pregnant women examined only returning to the prepregnant status in 25%-40%; 3. prevalence of goiter in newborn with 5%; 12.8% of 1948 stilborn had macroscopically an enlarged thyroid gland, the highest weight being 45 g. More than 53% of the stilborn examined by autopsy had a thyroid weight of over 3 g; 4. in contrast to the regions with sufficient iodine supply renal iodine excretion was steadily decreasing during pregnancy and post partum, changing the iodine deficiency from grade II to grade III; 5. low iodine excretion in newborn: 1.3 +/- 0.2 microgram I/day in goitrous (1.2 +/- 0.2 nmol I/mmol creatinine) 2.2 +/- 0.4 micrograms I/day in non-goitrous (2.0 +/- 0.4 nmol I/mmol creatinine); 6. according to ETR more than 50% of the pregnant examined showed a hypothyroid tendency. The pathophysiological changes during pregnancy caused by insufficient iodine supply can be met efficiently by careful thyroid hormone treatment or by the administration of 150 micrograms I daily. A mandatory iodine salt prophylaxis is demanded.

Adolescent↗
PubMed1986

Iodine deficiency disease in the GDR.

In the last decade several epidemiologic surveys were carried out in the GDR. The findings of all studies indicate consistently that the goiter is existing in the whole country increasing from the north to the south. Inhabitants of all ages are involved. The main cause appears to be an iodine deficiency of grade II. In the south of the GDR more than 90% of the groups examined are subjected to it. The introduction of iodinated salt prophylaxis is going on. An Interdisciplinary Iodine Commission has been established to control and coordinate these measures.

Adolescent↗
PubMed1985

[Bromocriptine therapy of prolactinoma in pregnancy].

A report is given about the course of pregnancy and delivery of two patients with prolactin-producing pituitary adenomas and therapy with bromocriptine. Different views about treatment of prolactinomas in pregnancy are discussed. Pregnancy care has to be in close cooperation between endocrinologists and obstetricians.

Adenoma↗
PubMed1984

[Effect of thyroid hormones on noradrenaline-stimulated lipolysis in obesity].

11 extremely adipose patients were over 4 days loaded with a noradrenalin infusion of 0.1 microgram/kg body weight/minute over 60 minutes before and after a daily application of 200 micrograms tri-iodothyronine. The determination of the free fatty acids and of glycerin resulted in a significant elevation basally as well as after stimulation with noradrenalin. Thus the lipolytic influence of the thyroid hormones is confirmed under in-vivo-conditions. The possible mechanisms of lipolysis in the fatty tissue are discussed on the basis of literature.

Adolescent↗
PubMed1984

[Intestinal flora under conditions of stress].

In healthy probands influenced by endocrinic stress (application of ACTH, growth hormone, and triiodothyronine) the microflora of the content of the duodenum and of the feces is examined. After three weeks, only, rising numbers of bacteria could be detected in the duodenal content. The number of the aerobic bacteria, mainly of the coliforms in the feces, decreased whereas the number of the anaerobic germs increased. This stress model seems to be suitable for such researches.

Adrenocorticotropic Hormone↗
PubMed1982

[Maternal and infant thyroid gland during pregnancy and in the postpartum period].

A survey is given of the clinically relevant changes in the thyroid hormone balance of the maternal organism. The total concentrations of thyroid hormone may on account of the increased carrier protein level be incorrectly interpreted in the sense of a hyperthyroidism. The latent hormone binding capacity, however, may by mistake indicate a hypothyroidism. For the determination of the functional position, therefore, a statement about the free hormone fraction is necessary. The TRH-test is evident in pregnancy. Beginning with the 12th week of pregnancy the fetal thyroid gland produces thyroid hormones, from the 16th to the 20th week of pregnancy the fetus is autonomous; and the pituitary gland-thyroid gland-axis is able to function nearly from the 20th week of pregnancy. The consequences resulting from this for the therapy of a disease of the thyroid gland of the mother are explained. Due to a massive TSH-flow with the birth typical changes of the hormone levels develop which may be used for the early recognition of the congenital hypothyroidism (TSH-screening). Possibilities of the diagnosis of the prenatal function of the thyroid gland as well as of the therapy of hypothyroidism are discussed.

Amniotic Fluid↗
PubMed1982

[The behavior of the thyrotropin-releasing hormone test in fasting with and without triiodothyronine administration].

It is reported on the performance of the 400 microgram TRH/TSH test in adipose persons in the course of a zero diet and on the effects of an application of 50 micrograms tri-iodothyronine during 7 days on the TRH/TSH test on the same conditions. During total fasting the basic and TRH-stimulating TSH-level shows a slight tendency of decrease, but scarcely significant changes. After application of 50 micrograms tri-iodothyronine an unequivocal suppression of the TSH-concentration in the serum is to be recognized. By these results and with the help of literary data by means of the most sensitive test of the diagnostics of hypothyroidism a general hypofunction of the pancreas could be excluded, as it was supposed in the low T3 syndrome. But tri-iodothyronine deficiency in some tissues is still discussed at present.

Adolescent↗
PubMed1982

[Results of thyroid hormone therapy in bland struma].

2,191 patients with bland struma were treated with tri-iodothyronine and a mixed preparation (thyreotom) for at least 2 years. Several clinical criteria were used for judgement. A good result could be obtained in 78.3 to 51.2% depending on the size of the struma (I-III). While in diffuse strumata good results were obtained in 87.8 to 69.0%, in nodular goitres we were successful only in 52.0-32.9%. The therapy may be successful at every age. Since with growing age the nodular goitres prevail, the chances of success become smaller. For the same reason there is a close correlation between age of the goitre and the therapeutic effect. The rate of success continuously decreases with growing age of the goitre. From this results that the therapy in goitre must begin early, before nodular and regressive changes, respectively, render the treatment difficult or render an acceptable result difficult.

Adult↗
PubMed1981

[Alkaline phosphatase isoenzymes and hyperthyroidism].

We determined the serum total alkaline phosphatase as well as the alkaline phosphatase isoenzyme pattern in untreated and treated hyperthyreoses in the condition of euthyreosis and compared them with those of a healthy control group. The isoenzyme patterns, expressed as L/K quotient, ranged between 1.3 and 2.5 in the normal group and between 0.3 and 1.3 in the group with hyperthyreosis. The increase of the total alkaline phosphatase in hyperthyreosis was nearly exclusively conditioned by the increase of the activity of the osseous isoenzyme. The latter was increased already also then, when the total alkaline phosphatase had not transgressed the upper border of the normal. Depending on the functional condition of the thyroid gland the liver isoenzyme did not show any significant changes. In the course up to one year under thyrostatic therapy the increased activity of the osseous alkaline phosphatase decreased into the normal region as an expression of the very slowly repairing hyperthyreosis-conditioned disturbances of the osseous metabolism. An increase of the activity of the total alkaline phosphatase or of the osseous isoenzyme in the initial phase of a thyreostatic therapy of the sequel of an increase of the reactive activity of osteoblasts and must not lead to diagnostic and therapeutic uncertainties. By reason of the high sensitivity of the L/K quotient in hyperthyreoses (L/K at 95.5 % below 1.3) with a simultaneously high specifity of 89.5% the alkaline osseous phosphatase is to be discussed by all means as a helpful parameter of the peripheral function of the thyroid gland.

Alkaline Phosphatase↗
PubMed1981

[Enlargement of the sella in primary hypothyroidism].

Length of the sella, depth of the sella and surface of the sella profile of 37 primary hypothyroids were compared with a normal group. All the three parameters were significantly different, though situated in the normal area. The results are discussed on the basis of literature. The reactive formation of hypophyseal tumours at adult age in primary myxoedema is relatively rare. However, in every enlargement of the sella also a primary hypothyreosis should be regraded differential-diagnostically. A therapeutic experiment with thyroid hormones should always be made.

Adolescent↗