Biomedical subjects
Publications and source records attributed to W Meister.
Two workers in a fish food store showed a professional asthma bronchiale against Daphnia. The diagnosis was proofed by typical anamnesis, scratch test, skin test and inhalative provocation test.
In contrast to the assessment of the vocational activity there are no fixed principles with regard to the application of defined methods of examination and the interpretation of its results. The assessment cannot be based only on the results of pulmonary function testing but has to take into consideration also the frequency and severity of the troubles, their dependence on vocational influence and their therapeutic management. The result of the function test using all given possibilities is essential. Sometimes are of decisive importance the arrangement of a mitable place of employment, the patient attitude to his disease and his vocational activities. In this paper proposals are given for a complex assessment of the physical capacity and invalidity in bronchial asthma.
Glucocorticosteroids are an integrating component of complex therapy in severe obstructive airways diseases. The well known risks of this treatment may be minimized by observing the following rules: 1. Rigorous indication for long term therapy 2. Careful attention to certain concomitant diseases and contraindications 3. Control of therapy by continuous specialized supervision in a dispensaire. On the basis of modern literature and personal experience with glucocorticosteroid therapy in 1210 patients with bronchial asthma and chronic obstructive bronchitis during the years 1972 to 1977 (34.9% of all patients in this group of diagnoses) are given some recommendations for practical handling of glucocorticosteroid therapy in obstructive airways diseases.
In increasing number of patients suffering from bronchial asthma are being examined by outpatients' departments for lung diseases and tuberculosis. The early confirmation of an allergic genesis is of main importance for therapy and prophylaxis. Primary allergological diagnostics in outpatients' departments are therefore desirable with special emphasis on allergological anamnesis, intracutaneous allergen tests respectively prick tests. Sufficient experience of the physician especially in the evaluation of results and consecutive measures is necessary. It is recommended to confine cutaneous testing to the usual antigens of airways allergy after careful elucidation of anamnesis. Testing with professional allergens and with allergens leading to strong reactions should be restrained to certain clinical centres. In addition to the recommendations of the Society for Clinical and Experimental Immunology of GDR for allergological and clinical immunological diagnostics the presented publication gives some hints to practical handling and to the evaluation of results.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Due to the mainly infectious genesis drug-therapy with antibiotics is essential in chronic non-specific respiratory diseases. But they are only indicated when a bacterial infection is suspected. The broad spectrum antibiotics usually have a reliable efficacy. Bacteriological examination is no obligate supposition. But it is necessary if new drugs with limited effectiveness are intended to be given. In most cases of chronic bronchitis an intermittent application is sufficient. A continuous treatment is indicated only in a few cases. Some details of antibiotic therapy (kind of drugs, dosage, duration of treatment, side-effects etc.) are discussed. The possibility of antibiotic therapy in respiratory virus infections is inquired.
Report is given on a metabolic investigation with non-radioactive and 14C-labelled methiothepin(1-[10',11'-dihydro-8'-(methylthio)-dibenzo mean value of b,f thiepin-10'yl]-4-methyl-piperazine) in rat, dog, and man. After i.p. and oral administration of the drug to the rat, the metabolites of methiothepin were excreted fecally. In the same species, a considerable biliary secretion of the compounds has been demonstrated. In dog and in man, excreted metabolites have been found both in urine and feces after oral application of the drug. The biotransformation of methiothepin within the species investigated proceeds via hydroxylation, sulfoxidation, O-methylation, N-demethylation, N-oxidation and formation of conjugates. The large number of metabolites is due to the various sites of action within the molecule, that are accessible to in vivo oxidation. Of a large number of isolated positionally isomeric compounds, merely the basal structures could be clarified. Possibly the mode of biotransformation to which methiothepin is subjected in the organism, proves determinant for the way of excretion. In the rat, all metabolites are hydroxylated and reach the intestinal tract as conjugates with the bile. In dog and man, however, non-hydroxylated, sulfoxidized metabolites were likewise found, which were excreted mainly renally in both species.
Modern chest hospitals offer favourable conditions for the rehabilitation of asthmatic patients. In the Central Hospital for Heart- and Lung Diseases at Bad Berka 421 patients with asthma were rehabilitated under clinical conditions in 1972 and 1973. Their rehabilitation was based on individualized long-term plans for treatment taking in consideration environmental factors which might have triggered the attacks. We report on experiences with diagnostic and therapeutic procedures and the results of vocational rehabilitation. 284 patients (67.4%) could return to their work, 4.5% were disabled, 16.5% remained invalids and 11.6% were old-age pensioners or children. The results depended on age, on the type of asthma, on the severity of cardio-pulmonary impairment, on certain concomitant diseases and on the patients cooperation. Possibilities for elimination of factors starting an attack sometimes proved decisive. For the maintenance of rehabilitatory success subsequent ambulatory long-term care by a specialist is provided.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.