Biomedical subjects
Publications and source records attributed to W Mehnert.
Administration of 6,7-dimethyl-9-(D-1-ribityl)-isoalloxazine (riboflavin) solution (30 mg/200 ml) dissolved in a fruit juice to 5 volunteers resulted in increased relative bioavailability between 156 and 246% compared to the intake with water. The reason should be the delayed gastric emptying rate due to the osmotic pressure and the acidity of the juice.
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Solid lipid nanoparticles (SLN) are a colloidal carrier system for controlled drug delivery. The lipophilic model drugs tetracaine and etomidate were incorporated to study the maximum drug loading, entrapment efficacy, effect of drug incorporation on SLN size, zeta potential (charge) and long-term physical stability. Drug loads of up to 10% could be achieved whilst simultaneously maintaining a physically stable nanoparticle dispersion. Incorporation of drugs showed no or little effect on particle size and zeta potential compared to drug-free SLN. The optimized production parameters previously established for drug-free SLN dispersions can therefore be transferred to drug-loaded systems to facilitate product development.