[EEG changes in cases of cerebrovascular diseases treated surgically].
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Carotid Arteries↗
Biomedical subjects
W Mazurowski
Publications and source records attributed to W Mazurowski.
[Case of giant aneurysm of the basilar artery].
The authors report a case of a giant aneurysm of the basilar artery of the brain diagnosed accidentally on autopsy. Slowly progressive syndrome of bulbar involvement began after craniocerebral trauma. Of considerable interest was the misleading result of pneumoencephalography which showed a normal pattern of basal cisterns. In the light of results of positive-contrast ventriculography an inoperable expanding lesion of the anterior part of the brain stem with associated hydrocephalus was diagnosed and symptomatic treatment was started inserting a Pudenz-Heyer valve. Despite normalization of intracranial pressure the patient died. Vertebral angiography would not have permitted the aneurysm to be diagnosed intravitally since its lumen was filled with clots.
Basilar Artery↗
[Neurotransplantation. III. Intracerebral grafting of fetal substantia nigra in Parkinson's disease].
The paper reports the results of fetal substantia nigra transplantations into the brain of patients suffering from Parkinson's disease, performed in different neurosurgical centers in the world. Commonly accepted Ethical Guidelines for Fetal Tissue Transplantations are presented. The criteria regarding patients selection for therapeutic transplantation are also discussed. The results of studies concerning the problem of optimal fetal age for transplantations are presented. The optimal age seems to cover the period between the 7th gestational week when dopamine synthesis begins and the 11th week when protoplasmic processes start to grow intensively. The damage of these processes during transplantation procedure is thought to make the fetal cells survival difficult. The discussion concerning controversial problem of immunosuppression treatment after the neurotransplantation is also reported. The paper presents the principles of signs and symptoms assessment before and after operation including CAPIT system which emphasises the role of movement ability tests, PET-scanning with [18F]-6-L-fluorodopa and magnetic resonance imaging. The PET-scanning allows to follow up the changes in patient's brain resulting from the graft survival and its dopamine synthesis ability. The methods of donor woman examination to avoid the transmission of infections into the patient's brain are reviewed. The analysis of yet published results of about 100 operated on parkinsonian patients show marked improvement due to human fetal substantia nigra transplantation. The improvement lasts, at least 46 months postoperatively (the longest period of observation). Many of the grafted patients returned to normal self-dependent living activities and some of them resumed even their professional jobs. Most authors present the opinion that the therapeutic effects of fetal substantia nigra transplantations are more valuable and longer lasting than those after adrenal medulla autografts. However it should be borne in mind that both methods are yet only the experimental approach in Parkinson's disease therapy.
Fetal Tissue Transplantation↗
[Contribution to the microanatomy of the proximal part of the arteria centralis longa (Heubner's artery)].
The anterior communicating artery complex is one of the most frequent intracranial aneurysm sites. Pterional craniotomy is the usual way to expose this region. While exposing of the aneurysmal dome, the posterior part of the gyrus rectus is frequently resected. In this stage of the procedure and later during clipping of the aneurysm, the surgeon's manipulation is closely related to the proximal part of the Heubner's artery. This vessel feeds important structures in the region of the basal ganglia. The anatomy of the Heubner's artery was described by many authors. However the intraoperative identification of this artery is still not clear. Therefore we performed detailed microanatomical investigation of the proximal part of the Heubner's artery in 40 brain hemispheres. It was found that during resection of the posterior part of the gyrus rectus two arteries are exposed. The recurrent Heubner's artery runs posteriorly to the gyrus rectus. The second artery runs on the medial and inferior surface of gyrus rectus supplying cerebral cortex. This artery frequently originates from the A1/A2 junction or the proximal part of the A2 segment of the anterior cerebral artery. Because of it, this cortical artery is difficult to distinguish from the recurrent Heubner's artery. This artery can branch out from the recurrent Heubner's artery or the frontopolar artery. In conclusion, the greatest probability of the injury to the recurrent Heubner's artery may occur during resection of the posterior part of the gyrus rectus.
Adult↗
[Evaluation of some hemodynamic indices in 15 to 18 year old boys with lipid risk factors for atherosclerosis].
The aim of the work was an attempt at answering the question whether there is any correlation between the haemodynamic indices describing arterial elasticity assessed by physical analysis of the circulatory system and lipid risk factors for arterial atherosclerosis in boys aged 15 to 18 years. The studies included 45 boys with lipid risk factors for atherosclerosis. The control group included 53 boys without lipid risk factors. In boys aged 17-18 years with lipid risk factors for atherosclerosis as compared with their peers with normal serum lipid level, a statistically significant change of arterial elasticity was found. A positive correlation was also found between the increased serum cholesterol level and the values of air-chamber elasticity index and peripheral vascular resistance, and a negative correlation was demonstrated between the decreased serum HDL-cholesterol concentration and the increase of pulse wave velocity in the aorta, air-chamber elasticity index and peripheral vascular resistance.
Adolescent↗