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Biomedical subjects

W Maier

Publications and source records attributed to W Maier.

At least 397 records · Page 22Linked to original sources
PubMed1988

Improving depression severity assessment--II. Content, concurrent and external validity of three observer depression scales.

The Hamilton Depression Scale (HAMD), the Montgomery-Asberg Depression Rating Scale (MADRS) and the Bech-Rafaelsen Melancholia Scale (BRMS) were compared with respect to content, concurrent and external validity in sample of 130 patients with a major depressive episode. The three scales did equally well in concurrent and external validity. The HAMD showed some deficiencies in content validity. The consequences for depression severity assessment are discussed.

Adult↗
PubMed1988

[In vitro bactericidal effects of ofloxacin on S. aureus].

Two Staphylococcus aureus (S. aureus) strains with differing susceptibility to penicillin G as expressed by the minimum inhibitory concentration were exposed in vitro over a period of 8 h to the continuously changing concentrations of ofloxacin achieved in human serum and cantharides blister fluid (CBF) after the single oral application of 600 mg. In both strains bacterial density was rapidly, but not totally reduced: a reduction by 99 percent took no longer than about 1 and 1.5 h resp. facing the serum level profile and about 1.5 h facing the tissue level profile. The maximum reduction of staphylococcal density in percent (kn) amounted to 0.0007 and 0.0034 and to 0.0038 and 0.0047 resp. Thus not only the serum level profiles but also the skin tissue level profiles obtainable in man proved highly effective in vitro against S. aureus irrespective of the bacterial suspectibility against penicillin G. Therefore oral ofloxacin should prove useful in staphylococcal diseases especially in so far as cutaneous tissue is involved.

Humans↗
PubMed1988

[Early diagnosis and staging of acute pancreatitis using computed tomography].

In 108 patients with acute pancreatitis, the CT findings were correlated with pathological staging; in 63 the diagnosis had been confirmed at operation and in 45 it was made on clinical grounds. CT differentiation between interstitial and necrotizing pancreatitis had a sensitivity of 0.87 and specificity of 1.0. In addition, exact estimation of the extent of intrapancreatic necrosis was possible. This high accuracy makes CT the method of choice for the early diagnosis and staging of acute pancreatitis.

Acute Disease↗
PubMed1988

[Experimental studies on the earliest echographic manifestations of incipient pancreatitis and pancreatic necrosis].

The earliest echographic manifestations of developing pancreatitis or pancreatic necrosis were studied experimentally in five dogs (Beagles). Fifteen minutes after induction of pancreatitis the pancreas was removed and accurately corresponding histological and sonographic serial sections were prepared. Pancreatic necrosis up to 25% was not apparent sonographically. 50% pancreatic necrosis manifested various echo patterns (low echoes, focal hyperechogenicity). 75% and 100% pancreatic necrosis showed characteristic sonographic appearances of focal-nodular hyperechogenicity on an hypo-echogenic background. The study has shown that sonography is a highly sensitive method for recognizing even the earliest stages of acute necrotizing pancreatitis.

Animals↗
PubMed1988

[Psychopathologic prediction of ambulatory doxepin response. A replication trial].

This study tries to replicate findings of a previous outpatient study, which revealed some clinical predictors of doxepine response in depressed patients. 314 depressed outpatients were treated by a total of 262 private practice psychiatrists for 6 weeks with 100 mg doxepine daily. The following findings of the previous study could be confirmed: 74% of the patients were therapy responders (score on the Hamilton Depression Scale after 6 weeks less than or equal to 8); unpredictability of diagnostic subtyping into endogenous and non-endogenous depression (clinically according to ICD-9 and operationally according to the Newcastle Scale); response-predictability of the personality assessment as not being deviant, defined according to the Newcastle Scale (no previous "nervous breakdowns", no previous neurotic symptoms, no severe social maladaptation); response-predictability of an improvement after 2 weeks over the initial Hamilton score of greater than or equal to 30%. The practical relevance of these three findings for outpatient therapy with antidepressive drugs is stressed.

Adolescent↗