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Biomedical subjects

W M Petrie

Publications and source records attributed to W M Petrie.

33 records · Page 2Linked to original sources
PubMed1981

The use of nicotinic acid and pyridoxine in the treatment of schizophrenia.

As part of the Canadian Mental Health Association Collaborative Study, the hypothesis that combined administration of nicotinic acid and pyridoxine has greater therapeutic effects than the component drugs in chronic schizophrenic patients was tested. This could not be substantiated in a 48-week study in which supplementation of neuroleptic treatment with a single vitamin, i.e., nicotinic acid or pyridoxine, produced significant therapeutic changes, while supplementation with both vitamins did not.

Adult↗
PubMed1980

Compulsive water drinking treated with high dose propranolol.

A patient with recurrent, life-threatening water intoxication secondary to compulsive water drinking is described. This patient responded well to nearly 1 g of propranolol daily with a decrease in her drinking behavior, reduced sensation of thirst, and a reduction in her delusional thinking. The rationale for the choice of propranolol with this patient is reviewed.

Adult↗
PubMed1980

Sexual effects of antidepressents and psychomotor stimulant drugs.

Sexual dysfunction is common in depressive illness, most often occuring as loss of sexual interest, impotence, and a decline in the frequency of intercourse. Antidepressant drugs have been documented to improve sexual function in depression; however, adverse effects of sexual function also occur as a result of the drugs' interference with peripheral cholinergic and adrenergic function. MAO inhibitors may also ameliorate depression-related sexual dysfunction. These drugs also improve sperm count and sperm motility and may have a clinical use in moderate oligospermia. Stimulant drugs have been linked to a wide variety of sexual effects. Most dramatic is the increase in sexual arousal reported by many stimulant users. Increases in sexual activity and sexual perversion have both been related to stimulant use. Due to the high rate of pre-drug sexual aberration and the non-specific nature of stimulant arousal, caution should be exercised in postulating a direct effect on sexuality by stimulant drugs.

Animals↗
PubMed1980

Mianserin: determination of therapeutic dose range.

Mianserin hydrochloride is a tetracyclic antidepressant with an EEG and clinical activity profile similar to amitriptyline. To investigate the drug's optimal dosage range, a 6-week open comparative trial sequentially assigned 12 depressed patients to one of three dose ranges (60, 90 and 120 mg). Improvement occurred in depressive symptomatology in all three treatment groups. There was no differential improvement noted in any group; however, the incidence of adverse effects was greater in the middle (90 mg) and high (120 mg) dose ranges.

Adult↗
PubMed1980

Viloxazine in the treatment of depressive neurosis: a placebo and standard (imipramine) controlled clinical study.

In a 4-week double-blind trial, 33 patients with depressive neurosis were randomly assigned to either viloxazine, imipramine or placebo. Statistically significant improvement was observed in all treatment groups. Imipramine exhibited significant improvement earlier in depressive symptoms, while viloxazine showed significant improvement earlier in anxious symptoms. The same frequency of treatment emergent symptoms occurred in the treatment groups. Premature termination as a consequence of adverse reactions was required in only 1 viloxazine and 1 placebo patient.

Adult↗
PubMed1980

Possible lack of anticholinergic effects with mianserin: a pilot study.

Anticholinergic effects of mianserin, a new tetracyclic antidepressant, were studied in 5 depressed patients. Prior to and after 1 and 2 hours of the administration of 30 mg of mianserin salivary flow, pupilary response to light and palpebral fissure were measured. Analysis of data revealed a statistically significant increase in salivary flow and a statistically significant decrease in pupil diameter. There was no change in palpebral fissure size. Possible clinical implications of these findings will be discussed.

Adult↗
PubMed1980

PCP.

Explore the source record for details and available documents.

Humans↗
PubMed1976

Affective psychoses following renal transplant.

Six patients who developed affective psychoses following renal transplantation ae reported. Each patient was treated, with careful management, with an appropriate somatic therapy (including phenothiazines, tricyclic antidepressants, electroconvulsive treatments and lithium carbonate). The results of this treatment approach were uniformaly successful. The similarity ofthe affective psychoses that developed in this patient population and those previously described psychoses attributed to steroid therapy is commented upon.

Adolescent↗
PubMedDate not supplied

Acute effects of viloxazine HCl and flurazepam when given alone and in combination on sleep EEG: a double-blind interaction study with normals.

Viloxazine, an aryl-oxypropanolamine type of beta-adreno-receptor antagonist, has been used in the treatment of depression. In a double-blind drug interaction study with flurazepam, a commonly used benzodiazepine hypnotic, viloxazine administered alone decreased the amount of time spent in REM sleep, increased the amount of time in the "light" stages of sleep, and increased the number of transitions to awake. However, no interactive effects of the combined administration of viloxazine and flurazepam could be detected.

Adult↗