Search PubMed⌕ Search

Biomedical subjects

W M Moore

Publications and source records attributed to W M Moore.

At least 73 records · Page 4Linked to original sources
PubMed1983

Relationship of fetal to placental size: the pig model.

Placental weight and macroscopic surface area are closely correlated with fetal weight throughout the second half of gestation in the pig. The limiting effect of placental size on fetal weight becomes more obvious as gestation advances. Fetal weight/placental weight ratio increases as placental weight decreases. Within individual litters, lightweight placentas have up to 150% more macroscopic surface area per unit placental weight.

Animals↗
PubMed1982

Duration of the premenstrual phase of the menstrual cycle estimated by oestrogen and LH urinary excretion and basal body temperature.

Three women recorded their daily basal body temperature and collected 24-h urine specimens for total oestrogens and LH measurement during 12 consecutive cycles and one women did so for six consecutive menstrual cycles. The variability in the time relationship between these indices of ovulatory events in serial cycles is presented. In the pooled data the duration of the premenstrual phase from oestrogen peak, LH peak, and temperature rise, to the end of the cycle is 12.9, 12.1, and 10.8 days, respectively. The time differences between these indices are found to be biological constants.

Adult↗
PubMed1980

Glucocorticoid effects of lymphosarcoma P1798 on DNA replication and growth of subcutaneous tumors in mice.

Injection of cortisol into BALB/c mice inhibited tritiated thymidine ([3H]dThd) incorporation into ascites cells of lymphosarcoma P1798 but not into cells isolated frm large subcutaneous tumors. The DNA synthetic index (SI), estimated autoradiographically after pulse labeling with [3H]dThd in vitro, was 0.25-0.29 for ascites cells and cells isolated from tumors having a radius squared (r2) less than 200 mm2. Cortisol decreased the SI of ascites cells by 90-95% within 5 hours. Similarly, cortisol decreased the SI of cells from subcutaneous tumors having an r2 less than 90 mm2. Growth and [3H]dThd incorporation were also inhibited by cortisol treatment of tumors with an r2 less than 90 mm2. However, when tumors became larger than 90 mm2, the SI did not decrease after cortisol treatment. Neither growth nor [3H]dThd incorporation was inhibited in tumors with an r2 greater than 90 mm2. These data indicate that tumors of lymphosarcoma P1798 became resistant to cortisol in a size-dependent manner. Loss of sensitivity ws not due to a gradual increase in the percentage of resistant cells.

Animals↗
PubMed1979

Physical growth: National Center for Health Statistics percentiles.

Anthropometry is an effective and frequently performed child health and nutrition screening procedure. The value of physical growth data depends on their accuracy and reliability, how they are recorded and interpreted, and what follow-up efforts are made after identification of growth abnormality. The new National Center for Health Statistics percentiles can be used to improve identification of potential health and nutritional problems and to facilitate the epidemological comparison of one group of children with others.

Adolescent↗
PubMed1977

Studies of nicotinic acetylcholine receptor protein from rat brain. II. Partial purification.

The pharmacological specificity of the binding of 125I-labeled alpha-bungarotoxin to a 1% Emulphogene BC-720 extract of a rat brain particulate fraction has been investigated. The extract contains a component which possesses the binding characteristics of a nicotinic acetylcholine receptor protein. The crude soluble acetylcholine receptor protein was purified by affinity chromatography utilizing the alpha-neurotoxin of Naja naja siamensis as ligand and 1.0 M carbamylcholine chloride as eluant. A single, batch-wise, affinity chromatography procedure yields an average purification of 510-fold. When this purified material is treated a second time by affinity chromatography, purification as high as 12600-fold has been obtained. Binding of 125I-labeled alpha-bungarotoxin to this purified acetylcholine receptor protein is saturable with a Kd of 1 - 10(-8) M. Nicotine and acetylcholine iodide at concentrations of 10(-5) M inhibit 125I-labeled toxin-acetylcholine receptor protein complex formation by 41 and 61% respectively. At 10(-4) M, carbamylcholine chloride and (+)-tubocurarine chloride give respectively 52 and 82% inhibition. Eserine sulfate and atropine sulfate have no effect on complex formation at a concentration of 10(-4) M. These data support the isolation of a partially purified nicotinic acetylcholine receptor protein.

Acetylcholine↗
PubMed1976

Studies of nicotinic acetylcholine receptor protein from rat brain.

Specific binding of 125I-labeled alpha-bungarotoxin to a 34800 X g pellet of a whole rat brain homogenate has been obtained at levels of 2 pmol toxin per g of whole brain with a Kd of 8-10(-9) M. Binding is reduced 90% by 10(-5) M (+)-tubocurarine chloride and 10(-4) M nicotine, whereas concentrations of 10(-4) M choline chloride, atropine sulfate and eserine sulfate have essentially no effect on toxin binding. These results compare closely with those obtained from binding studies with 125I-labeled alpha-bungarotoxin and soluble acetylcholine receptor protein preparations from Torpedo nobiliana; suggesting that this mammalian receptor protein is nicotinic in character. Extraction of the 34800 X g pellet with 1% Emulphogene yields a soluble fraction with specifically binds 125I-labeled alpha-bungarotoxin with a Kd of 5-10(-9) M. Nicotine and alpha-bungarotoxin at concentrations of 10(-5) M abolish toxin-receptor complex formation and carbachol and (+)-tubocurarine chloride reduce complex formation 35-40% at similar concentrations. Eserine sulfate, atropine sulfate, decamethonium, and pilocarpine had no effect on complex formation at concentrations of 10(-5) M.

Acetylcholine↗
PubMed1976

Fetal growth retardation in the second trimester.

Growth of the fetal head was assessed by serial ultrasonic measurements in a prospective study of a randomly selected group of 126 mothers. Three cases exhibiting second trimester fetal head growth retardation with varying degrees of catch-up growth before term are illustrated.

Female↗