Biomedical subjects

W M Liao

Publications and source records attributed to W M Liao.

9 recordsLinked to original sources

PubMed2000

Expression of nm23 protein in human osteosarcoma in relationship with early metastasis.

Nm23 protein expression was analyzed by immunohistochemical staining using formalin-fixed, paraffin-embedded sections from 39 cases with osteosarcomas and compared with the histologic findings and early metastasis for the purpose of detecting nm23 expression in osteosarcoma and elucidating the clinical significance of its expression. Immunoreactivity of nm23 protein was detected in 48.7% of the total cases. There was no statistical difference between nm23 expression and early metastasis, but there was a trend for cases with nm23 expression to progress to early metastasis within 1 year after operation. The role of nm23 as a tumor metastasis suppressor in osteosarcomas appeared less prominent.

Adolescent↗

PubMed1995

Studies on dental high-speed cutting.

The primary author, an experienced dentist, cut bovine enamel and dentine horizontally and vertically with diamond points driven by an air-turbine, while the rotational cutting speeds and applied loads were simultaneously monitored. Three cutting techniques employed here were successive cutting with moderate force (S-m); intermittent cutting with moderate force (I-m); and intermittent cutting with a smaller force (I-s). It was found that the cut contact time of S-m, I-m and I-s cuts were about 10s, 0.4s and 0.25 s, respectively. The maximum applied load during cutting varied, depending upon the cutting direction and the cutting technique. Vertical S-m cut of enamel resulted in the largest applied load of around 105 g, while horizontal I-s cut of dentine brought about the minimum (approximately 35 g). Cutting volumes of dentine tended to exceed those of enamel. It was confirmed that the I-m cut produced larger cutting effectiveness of diamond points on both enamel and dentine compared with the S-m cut.

Animals↗

PubMed1989

[Amplification, rearrangement and over-expression of c-fos gene in human primary brain tumors].

The c-fos gene was used as a probe to detect the Bam HI-digested brain DNA and total RNA isolated from 2 cases of normal human brain and 11 cases of human brain tumor by Southern blot analysis and RNA dot hybridization technique. The result showed an amplification and over-expression of c-fos gene in one case of glioblastoma multiforme. These data suggest that the c-fos gene may take an important role in the carcinogenesis of human primary brain tumor, and the level of c-fos expression may be correlated with the degree of differentiation of brain tumor cells. We also found that there was a rearrangement of c-fos gene in one case of ependymoma. This suggests that, in ependymoma, the c-fos gene may be activated in a way different from that in the brain tumors of astroglia origin.

Brain Neoplasms↗

PubMed1988