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Biomedical subjects

W M Jay

Publications and source records attributed to W M Jay.

At least 55 records · Page 3Linked to original sources
PubMed1983

Multiple-drop study of topically applied 1% delta 9-tetrahydrocannabinol in human eyes.

Twenty-eight male volunteers were given either 1% delta 9-tetrahydrocannabinol (delta 9-THC) or vehicle alone (light mineral oil). They used the medication four times per day for one week. Five volunteers, four of which used vehicle alone, discontinued the study because of burning sensation and lid swelling. In the 23 volunteers who completed the study, there was no difference in intraocular pressure between eyes treated with 1% delta 9-THC and controls.

Administration, Topical↗
PubMed1983

Benign intracranial hypertension in pregnancy: current diagnostic and therapeutic approach.

Four cases of benign intracranial hypertension (BIH) in pregnancy are presented. Literature regarding this rare entity is reviewed. Various diagnostic and therapeutic approaches in the management of BIH are described, with special emphasis on the newer neurodiagnostic and neurosurgical approaches. Guidelines have been suggested in diagnosing and managing this syndrome in pregnancy.

Adolescent↗
PubMed1983

Anaerobic orbital cellulitis.

A 10-year-old boy with orbital cellulitis died seven weeks after admission to the hospital despite intensive surgical intervention and medical therapy. We isolated many anaerobic bacteria from the orbit, frontal sinus, and epidural space. Orbital cellulitis, which often occurs by direct extension from infected paranasal sinuses, commonly affects children and young adults, and is a potentially lethal disease, if left untreated. Heightened awareness of the role of anaerobes in chronic sinusitis and of the possibility of an anaerobic orbital cellulitis may lead to the identification of more cases. Penicillin G appears to be the first drug of choice in cases with suspected anaerobic orbital cellulitis. Chloramphenicol and clindamycin should be considered, if treatment with penicillin fails. Antibiotics alone should not be considered as a panacea, and surgical drainage is often the most compelling consideration.

Anaerobiosis↗
PubMed1982

Opsoclonus in Hemophilus influenzae meningitis.

We studied a 3-month-old boy who had opsoclonus in association with acute bacterial meningitis. The CSF IgG and IgM were elevated acutely, gradually returning to normal with clinical improvement. Correspondingly, CSF cytomorphology showed excessive plasmocytosis and a higher proportion of reactive lymphocytes than expected in an acute bacterial meningitis. These abnormalities in CSF cytology are effects of an abnormal immune response in the CNS, and provide evidence to support an immunopathic basis to opsoclonus.

Eye Movements↗
PubMed1981

Treatment of chronic ocular pain by selective thermocoagulation of the trigeminal ganglion.

We used graded radiofrequency heating to destroy pain fibers in the ophthalmic division of the trigeminal ganglion while sparing most of the touch fibers in nine patients (seven men and two women, ranging in age from 51 to 74 years) with chronic ocular pain. All nine experienced immediate and complete pain relief. Although one patient required a second procedure after 57 months, the other eight have been pain-free for 44 to 59 months. There were no serious complications. The corneal reflex was preserved and there was no damage to the optic or extraocular muscles.

Aged↗
PubMed1981

Visual field defects.

There are four classic types of visual field defects. Altitudinal field defects in which the defect is present above or below the horizontal midline are usually associated with ocular abnormalities. A central scotoma is characteristic of optic nerve disease of macular disease. A bitemporal hemianopia signifies optic chiasm disease and is most frequently associated with pituitary tumors. With homonymous hemianopia, the same portion of the field is absent in both eyes, and is found with lesions behind the chiasm.

Eye↗
PubMed1981

Improved viewing of half-tone display of Octopus perimeter.

The half-tone display of the Octopus perimeter utilizes circles and squares of various sizes as symbols for static threshold levels of light sensitivity in localized areas of the visual field. Under normal lighting conditions at a normal reading distance the symbols do not blur into shades of gray, thus limiting the clinician's ability to screen quickly for contour abnormalities. Four methods that enhance contour discrimination of the half-tone display are (1) viewing at a distance, (2) viewing in dim light, and using either a (3) -14 diopter or (4) +20 diopter lens. In a survey conducted to determine ophthalmologists's preferences, all methods were ranked superior to viewing under normal conditions of lighting and reading distance.

Aged↗
PubMed1979

Lymphocyte stimulation by yeast phase Histoplasma capsulatum in presumed ocular histoplasmosis syndrome.

We measured skin reactions serum antibody, and lymphocyte stimulation to Histoplasma antigens in a series of patients with presumed ocular histoplasmosis syndrome and in controls. The most sensitive test, lymphocyte stimulation to H. capsulatum sonicate, also correlated with severity of the disease. Lymphocyte stimulation to Histoplasma may be a useful adjunct to the monitoring of presumed ocular histoplasmosis syndrome.

Antibodies, Fungal↗
PubMed1979

Medical therapy of metastatic meningococcal endophthalmitis.

We treated a 15-year-old girl who had meningococcal meningitis and metastatic endophthalmitis with large doses of intravenously administered penicillin G. The patient promptly improved with this therapy, and the visual axis completely cleared during the subsequent five months.

Adolescent↗
PubMed1979

Nabilone: a pressure-reducing synthetic benzopyran in open-angle glaucoma.

Nabilone is a synthesized crystalline benzopyran that resembles the cannabinols but is not a tetrahydrocannabinol. Oral administration of 0.5 to 2 mg to patients with open-angle glaucoma reduced the intraocular pressure from 10% to 54% with an average of 28%. Administration of a topical ophthalmic nabilone solution (0.1 mg/drop) to both eyes of adult albino rabbits (1.5 to 3.5 kg) lowered the IOP an average of 25%. The peak action of the nabilone administered in this manner was 60 minutes, with a return to normal IOP by 180 minutes. Tolerance developed in rabbits after one week of topical administration.

Administration, Oral↗
PubMedDate not supplied

Congenital bilateral horizontal gaze palsy in a brother and sister.

A man of 21 years and his sister aged 20 years had congenital bilateral horizontal gaze palsy. Convergence was normal but the vestibulocephalic and oculocephalic reflexes were absent. Aplasia of the paramedian zone of the pontine tegmentum, on a familial basis, is postulated as the cause.

Adult↗