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Biomedical subjects

W Likoff

Publications and source records attributed to W Likoff.

At least 19 recordsLinked to original sources
PubMed1981

Unstable angina pectoris of new onset: a prospective clinical and arteriographic study of 75 patients.

Seventy-five patients with unstable angina pectoris of new onset (defined as of less than 90 days' duration) were prospectively evaluated in terms of clinical and arteriographic findings. In all patients the angina was considered unstable in terms of ease of provocation of anginal attacks and frequency of occurrence of attacks. Sixty patients had significant obstruction of at least one coronary artery, whereas 15 had insignificant disease (less than 70 percent arterial narrowing) or normal coronary arteries. Thirty-one patients (52 percent) had single vessel coronary disease, 11 (18 percent) had double vessel disease and 9 (15 percent) had triple vessel disease; the remaining 9 (15 percent) had left main coronary artery disease, either alone or in association with other vessel involvement. Of the 31 patients with single vessel disease, 24 (77 percent) had stenosis of the left anterior descending artery. The patients with single vessel disease did not differ from the patients with multivessel involvement with respect to risk factors or clinical presentation. It is concluded that patients with unstable angina of new onset have an unusually large incidence of single vessel coronary artery disease predominantly involving the left anterior descending coronary artery. Thus, these patients constitute a unique subset of patients with angina pectoris.

Adult↗
PubMed1977

Coronary risk factors and anginal pain patterns.

Major risk factors for coronary heart disease include hypertension, high serum cholesterol and triglyceride levels, and cigarette smoking. Minor risk factors include glucose intolerance, electrocardiographic changes, and personality type. Often the initial manifestation is angina pectoris. To prevent coronary heart disease, physicians need to know the answers to the following questions: (1) In which person will coronary heart disease develop, and when? (2) What is the cause? (3) What major and minor causative factors can be modified? (4) How can these modifications be achieved in a free-living, working, well population? (5) What is the earliest manifestation of coronary atherosclerosis? (6) What special diagnostic procedures are useful in coronary heart disease? These subjects are examined briefly.

Aged↗
PubMed1977

Medical management of angina pectoris.

Nitroglycerin should be the first agent prescribed for patients with angina pectoris. When nitroglycerin is used daily, a trial with longer-acting nitrates (eg, isosorbide dinitrate) is warranted. If angina persists, use of beta-adrenergic blocking agent (propranolol) should be considered. Appropriate use of nitrates and propranolol, singly or in combination, will relieve angina pectoris due to coronary heart disease in most patients.

Angina Pectoris↗
PubMed1977

Impending myocardial infarction: medical management.

It is our practice to suggest coronary arteriography for patients with impending myocardial infarction who respond poorly to medical managemnt. Aortocoronary saphenous vein bypass surgery is advised for patients with unstable angina and left main coronary disease. Surgery is not advised for patients with minimal irregularities of the coronary arteries (less than 50% obstruction). Rarely is surgery advised for patients with the syndrome of impending myocardial infarction in whom only the right coronary artery or the left circumflex artery is obstructed. Bypass surgery should be seriously considered for patients with unstable angina and hemodynamically significant disease involving the proximal left anterior descending coronary artery (proximal to the first septal perforating branch). On the basis of symptomatic improvement alone, surgically treated patients with the syndrome of impending myocardial infarction seem to fare better than do those treated medically.

Angina Pectoris↗