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Biomedical subjects

W Lichtenegger

Publications and source records attributed to W Lichtenegger.

At least 55 records · Page 3Linked to original sources
PubMed1995

[C-erbB-2, EGF receptor, p53 and PCNA. The prognostic significance of recent tumor markers for lymph node negative breast cancer].

In 216 breast cancer patients, the prognostic value of current biological factors (c-erbB-2, EGF-receptor, p53, PCNA-proliferative fraction) was compared with that of conventionally histomorphologic features (histologic type, histologic grade, tumour size, hormonal receptor status). After a 66(6 - 109) months' median follow-up survival was significantly correlated with histological grade (p = 0.014) and PCNA-proliferative activity (p = 0.015). The prognostic influence of oestrogen receptor (ER)- and progesteron receptor (PR-)status achieved borderline significance (ER/p = 0.07; PR/p = 0.05). Neither c-erbB-2, EGF-R, p53 nor any of the other factors showed any correlation to survival. In the multivariate analysis, histological grade was revealed as the only independent prognostic factor. The prognostic value of PCNA was second to histological grade and if grade was excluded from the analysis, PCNA-expression became the only independent factor. Thus, in individual cases the PCNA-proliferative fraction could help the clinician to decide on the therapy.

Adult↗
PubMed1995

The vaginal radical operation of cervical cancer.

Choosing the surgical technique for the cervix carcinoma--vaginal or abdominal--it is particularly necessary to take into account the lymphatic spread of the cervix. As it is not possible to realize a lymphadenectomy in a vaginal procedure, it has to be found a preoperative diagnostic method which enables very surely the exclusion of lymph node involvement. In summary of the facts stated up to now, one can conclude as follows: 1. The FIGO-classification is too subjective. 2. There is a significant correlation between tumor volume and lymph node involvement. 3. The tumor markers--as e.g. PCNA, p53, c-neu, EGF, beta 1 Integrin etc.--show no correlation with the lymph node involvement. 4. Only MRI allows an exact preoperative measurement of the tumor volume. 5. On account of the above mentioned results, it seems to be possible to extend the indication for the vaginal radical surgery on cases with a small tumor volume.

Biomarkers, Tumor↗
PubMed1995

[Overexpression of p53 protein in ovarian carcinomas: correlation with histopathologic data and clinical course].

OBJECTIVES: The accumulation of p53 protein was analysed immunohistochemically in ovarian cancer and correlated with clinical data to further clarify the role of p53 mutations for prognosis in these patients. METHODS: Tumor tissues from 126 epithelial ovarian carcinomas were analysed immunohistochemically on paraffin embedded tissue and in 21 cases on frozen tissue with monoclonal antibodies PAb 1801, PAb 421 and PAb 240. RESULTS: Nuclear p53 staining was found in 31 ovarian carcinomas (25%) and correlated with advanced stage of the disease (p = 0,038) and poor differentiation (P = 0,032) of the tumor. Disease-free and overall-survival time were slightly, but not significantly shortened for patients with p53 positive tumors. CONCLUSION: Immunohistochemically detectable p53 protein expression in ovarian carcinoma is associated with poor differentiation, advanced stage of the disease and a tendency for shortened disease-free and overall survival.

Adult↗
PubMed1995

[Ultrasound detection of breast cancer with normal mammogram].

In eleven patients with breast cancer the diagnosis was made by using ultrasound as the only method. In none of the patients could mammography show the malignoma. Although six of the patients underwent additional tube X-ray investigation, no radiological criteria of malignancy were found on the mammograms. In ten patients a lump of the breast was palpable and/or retraction of the skin was visible. In one woman, neither the clinical investigation nor the mammography could reveal the tumor. The ultrasound of the breast is a indispensable and useful method for diagnosing breast cancer.

Adult↗
PubMed1994

[Mucocele of the appendix as a rare differential diagnosis of adnexa tumor].

It will be reported of a 68 year old woman, who underwent a laparotomy because of a tumor of the right ovary, which was ultrasonographically suspicious of being malign. During the operation, it was diagnosed as a mucocele of the appendix. It will be discussed, whether ultrasound is able to differentiate tumors of the lower right abdomen. Mechanisms of development and clinical signs of the mucocele of the appendix will also be described.

Aged↗
PubMed1993

[Surgical technique of subcutaneous/skin preserving tumor-adapted mastectomy].

Subcutaneous mastectomy as a procedure to prevent breast cancer has been abandoned because of the insufficient resection of breast tissue and the high rate of complications. Including the recent experiences in reconstructive breast surgery the subcutaneous mastectomy allows a degree of tissue resection comparable to total mastectomy with a lower rate of complications. Surgical technique, our own results and new indications for subcutaneous mastectomy are presented.

Adult↗
PubMed1992

[The course of labor in intrauterine fetal death].

The results of the course of birth in 71 intrauterine cases of foetal death are presented. There were spontaneous deliveries in 82% of the cases and in 4% a vacuum extraction was performed. The relatively high rate (14%) of Caesarean sections was in most cases, due to maternal indication. The introduction of prostaglandins was a significant progress factor in birth induction of these disturbed pregnancies. All 36 patients (51%) were treated with sulprostone (mostly intravenously). Furthermore, intrapartal, directly postpartal complications and complications of early puerperium are discussed.

Adult↗
PubMed1992

[Fibromatosis of the breast].

Fibromatosis of the breast is a rare benign mesenchymal transformation of the connective tissue, the origin of which is probably situated in the fascia of the pectoral muscle and the Cooper's ligaments. In the clinical and radiological examination, it is difficult to differentiate between a mammary carcinoma or other malignant tumours of the breast. Only histological examination can lead to the final diagnosis. Large-scale excision of these tumours, which have a tendency to relapse, is the therapy of choice. The diagnostic problems are shown in a case of a 26-year old patient.

Adult↗
PubMed1992

[Mucinous metaplasia of fallopian tube mucous membrane as a cause of pseudomyxoma peritonei].

A woman aged 49 years was relaparotomized at the Gynaecological Department of the "Rudolf Virchow" Medical Centre of the Free University of Berlin, following diagnosis of metastatic mucinous adenocarcinoma. Proliferative mucinous metaplasia of the Fallopian tube and consecutive peritoneal pseudomyxoma were established as clinical findings and were hypothetically attributed to mucinous metaplasia of the salpingofimbrial mucosa. Neither mucocele of the appendix nor ovarian tumour were found. This possible site origin has been rarely mentioned in any case report in the past.

Adenocarcinoma, Mucinous↗
PubMed1992

[Mucocele of the appendix in highly differentiated adenocarcinoma].

A patient 69 years old had been admitted at the University Women's Hospital Berlin because of a suspected ovarian tumour. Outside a computed tomography was done. In the small pelvis a tumour partly cystic and partly solid at the right side could be confirmed sonographically. Because this an operation was indicated. After opening the abdomen the internal female genital organs were in conspicuous with the exception of extensive adhesions. Histologically we found a mucocele of the vermiform appendix with a highly differentiated adenocarcinoma. All tissue layers were infiltrated and perforated. This combination of findings is very seldom, because carcinomas of the appendix could be proved only in 0.01 per cent of all appendectomies.

Adenocarcinoma↗
PubMed1992

[The place of radioimmunoscintigraphy in the diagnosis and follow-up of ovarian cancer in comparison with computed tomography and second-look surgery].

In this prospective study the diagnostic capability of radioimmunoscintigraphy (RIS) was compared with that of computed tomography (CT) and of "second look" surgery as primary diagnostic procedures in 27 patients and in the follow-up of 52 women suspected of suffering from ovarian cancer. The results were compared with immunohistochemical findings and CA125 serum levels. For primary diagnosis sensitivity, specificity and diagnostic accuracy of RIS was 100%, 60% and 90%, resp. In follow-up, sensitivity for local recurrencies was 75% and specificity 68%. Peritoneal carcinosis in the pelvis and lower abdominal region was better detectable by RIS, but for detection of liver metastases CT showed better results. CT and RIS could not replace "second look" surgery.

Adult↗
PubMed1991

[Coexistence of endometroid carcinoma of the ovary and endometrial carcinoma in a 32-year-old woman].

At our hospital a 32 year old patient with a cystic ovarian had been operated. Because sonography was without pathological findings and the patient showed a sterility type, laparoscopy was indicated. Histological findings showed invasive growth of a tubulopapillary carcinoma. Laparotomy with hysterectomy, bilateral adnexa removal, omentectomy as well as pelvic and para-aortic lymphadenectomy was examined. Histologic and immunohistochemical investigations led to coexistence of ovarian endometroid carcinoma and to an endometrial carcinoma, both tumors being of different antigenicity.

Adenocarcinoma↗
PubMed1990

Urological complications after radical hysterectomy with or without radiotherapy for cervical cancer.

We reviewed urologic complications in 320 patients who underwent radical abdominal hysterectomy for stage Ib-IIb cervical cancer. 145 patients received adjuvant radiotherapy, and 116 were available for urodynamic testing 1-14 years later. The overall incidence of fistulas was 4.4%. Three of eight fistulas following surgery alone healed spontaneously; all fistulas following adjuvant radiotherapy required surgical correction. Nocturia and urgency were reported more often after adjuvant radiotherapy than after surgery alone. We conclude that urologic complications after radical hysterectomy can be made more intractable by adjuvant radiotherapy.

Adult↗
PubMed1990

[Pseudomyxoma peritonei caused by proliferating mucinous adenoma of the fimbria mucosa].

Omentectomy was conducted on a 49 year old patient at the Dept. of Surgery of the UFK Berlin-Charlottenburg because of a mucinous adenocarcinoma, without prior detection of the primary tumour site. Relaparotomy revealed proliferative mucinous adenoma of the Fallopian tube and a consecutive pseudomyxoma peritonei. Up to now, this seems to be the first case report of a mucinous adenoma of the Fallopian tube.

Adenocarcinoma, Mucinous↗
PubMed1989

The importance of parametrial lymph nodes in the treatment of cervical cancer.

This study aimed to determine the presence, distribution, and metastatic involvement of lymph nodes in the parametria of patients undergoing radical hysterectomy for cervical cancer. Parametrial nodes were present in the giant sections of 280 (78%) of 359 surgical specimens, and metastatically involved nodes were found in 63 (22.5%) of these 280. Both positive and negative nodes were distributed through the entire parametrium. The frequency of positive nodes was linearly associated with both the clinical stage and with the tumor volume. The recurrence rate was higher when the parametrial nodes were positive than when they were negative. Survival dropped when the parametrial nodes were positive, regardless of the clinical stage.

Female↗