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Biomedical subjects

W Lehmann

Publications and source records attributed to W Lehmann.

At least 217 records · Page 12Linked to original sources
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[Monitoring of the treatment of endogenous depression with imipramine and amitriptyline (preliminary report)].

Monitored treatment of a depressed phase of unipolar affective disorder was conducted in 11 female patients receiving imipramine and in 12 females taking amitriptyline. Patients were randomly assigned to one of the drug and in 6 patients the drugs were switched because of the lack of response to the first used compound. In the imipramine treated group a satisfactory response after 4 weeks of management (less than 6 points on Hamilton's depression scale) was observed in 6 patients and in amitriptyline treated group in 5 patients. Patients displaying a satisfactory response to amitryptyline had significantly higher--as compared to remaining patients in the group--plasma levels of the drug after two and four weeks of treatment. Such an association was not observed in patients treated wtih imipramine. Severity of depression and motor retardation before the treatment was similar both in patients with satisfactory and with poor response to imipramine as well as to amitriptyline. However the intensity of anxiety symptoms was higher in patients exhibiting poor response to treatment with amitriptyline and imipramine as well.

Adult↗
PubMedDate not supplied

[Pharmacokinetic studies following 2 and 4-week Felbinac gel administration to the knee joint].

Twelve patients with osteoarthrosis were locally treated with Felbinac Gel (biphenyl acetic acid (BPAA) 3%) three times daily for 14 days (five patients), 28 days (six patients) or 42 days (one patient) before elective knee joint surgery. BPAA plasma concentrations as of the seventh day of treatment were steady at between 423 and 1040 ng/ml. In surgery, synovial and tissue samples were taken to determine BPAA concentrations. Moderate and sometimes higher synovial BPAA levels in the treated knee joint compared to the contralateral knee seem to indicate a combined direct and systemic absorption. The highest BPAA concentrations (1497-13939 ng/g) were measured in the skin. Drug levels in the synovial membrane (36-994 ng/g), the synovia (104-768 ng/ml), tendon (less than 10-197 ng/g), cartilage (less than 10-109 ng/g), muscle (12-101 ng/g), and subcutis (16-97 ng/g) were lower. BPAA neither accumulates in the skin, nor in any other peri-articular tissue. A steady state was reached as of the 14th day of treatment at the latest. None of the patients reported any local or systemic side effects.

Aged↗
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Dissimilar effects of lithium and carbamazepine on erythrocyte lithium transport in vivo: clinical implications.

The effect of lithium (Li) and carbamazepine (CBZ) on erythrocyte lithium transport in vivo was investigated in 28 patients with affective or schizoaffective illness (14 given Li and 14 given CBZ). In 12 of them, Li or CBZ were added to current psychotropic treatment. The activities of erythrocyte lithium-sodium countertransport (LSC), lithium-potassium cotransport (LPC) and passive lithium diffusion (PLD) were assayed before and after 28 days of treatment. The administration of Li caused a significant decrease of LPC as well as PLD activity. The administration of CBZ resulted in a significant increase of the activity of LPC system. No systematic relationship was observed between Li or CBZ-induced alterations in erythrocyte transport and changes in clinical state of patients. The possible clinical implications of the dissimilar effect of Li and CBZ on erythrocyte lithium transport are discussed.

Adult↗
PubMedDate not supplied

[Initial experiences in the combined treatment of aphasia patients following cerebrovascular insult by speech therapists and music therapists].

With the publication we try to indicate the common work of speech therapist and music-therapist of the medical treatment of aphasic patients after a cerebrovascular accident (stroke). This combined method of medical treatment has been proved best. In the geriatric centre in Berlin-Buch the co-operation is carried out in the following way: the logopaedic diagnosis of the kind of aphasia is so that the speech therapist and music-therapist can start treating the patients suffering from aphasia with special modified therapy programmes which is coordinated with each other. Most patients can be treated with logopaedic methods successfully. Patients who are difficult to treat with logopaedic methods get additional music therapeutic treatment so that the whole success of medical treatment becomes more comprehensive and more effective.

Aged↗
PubMedDate not supplied

[Logopedic considerations in the diagnosis and therapy of aphasia patients following stroke].

It was observed that one-third of all patients suffer from aphasic disturbances following cerebrovascular insult. Therefore, there is a need for special logopedic diagnostics and treatment in the framework of the complex rehabilitation program. From a practical point of view, the following diagnostic and/or therapeutic methods have proved successful: --the Aachen aphasia test; --stimulation treatment, circuitous methods, and compensatory techniques. It was proven that by a special logopedic therapy an obvious improvement of the different aphasia forms has been achieved.

Aged↗
PubMedDate not supplied

Studies of lithium pharmacokinetics in patients with affective illness.

Lithium pharmacokinetics after a single dose and pharmacokinetic prediction of optimal lithium carbonate dose in steady-state, were investigated in 15 patients with affective illness. In nine patients the course of plasma concentration after a single dose was characteristic for two-compartment and in six patients for one-compartment model. Patients fitting the two-compartment model required higher daily lithium dose to achieve steady-state therapeutic lithium level than patients fitting the one-compartment model. A significant correlation was found between plasma lithium level 12 and 24 h after a single dose and the daily dose required for achieving optimal lithium level in the course of subsequent lithium administration.

Adult↗
PubMedDate not supplied

Pharmacokinetics of carbamazepine in psychiatric patients.

Plasma levels of carbamazepine (CBZ) were studied in 10 patients with psychiatric illnesses who were given the drug every 12 hours for 28 days. No correlation has been found between the daily dose of carbamazepine (calculated for body weight) and the steady-state level of the drug. In most patients taking CBZ as the only drug, a 10-20% fall in plasma drug level occurred between the first and second week of treatment, suggesting autoinduction process. A significant correlation was obtained between the plasma level of CBZ measured after the first dose of the drug and the subsequent steady state concentration. This makes possible to predict the steady-state CBZ concentration early in the treatment.

Adult↗