[1767-1817. 50 years of hoof-and claw experience at the Vienna school. A historical sketch on the beginning of the specialty].
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Austria↗
Biomedical subjects
W Lechner
Publications and source records attributed to W Lechner.
[Increased spontaneous uterine motility with serotonin].
The influence of serotonine, a vasoactive neurotransmitter, on the spontaneous motility of uterine strips was investigated. A highly significant (p less than 0.001) increase of uterine activity was observed when serotonine 10(-6) M was added to the perfusing medium.
Cesarean Section↗
[Serotonin antagonism and uterine activity].
The influence of naftidrofuryl, a serotonin blocking agent on the spontaneous motility of 25 myometrial strips collected during cesarean section was investigated. A highly significant (p less than 0.0001) reduction of the uterine activity after the application of naftidrofuryl 10(-6) was observed.
Female↗
[Heart-specific L-myosin in pregnancy and tocolysis therapy].
Determination of light-chain (L-)myosin represents the currently most sensitive and specific method for detection of myocardial damage, which often was reported during tocolysis with betamimetics. Compared with 51 healthy pregnant subjects, it was not possible to demonstrate any pathologic increase in 14 patients, who underwent a tocolytic treatment with ritodrine-verapamil.
Adult↗
[Blockade of postsynaptic adrenergic alpha receptors--a new principle for inhibiting uterine contraction].
In analogy to beta 2 mimetic agents, also alpha 1 adrenoblockers should show an uterus-relaxing effect. Therefore, the tocolytic effect of prazosin, which is supposed to be the most potent alpha 1 blocking agent, was investigated in myometrial strips. Uterine activity was highly significantly (p less than 0.001) decreased by reduction of frequency and amplitude, but not by duration and area of spontaneous uterine contractions.
Culture Techniques↗
[Inhibition of uterine contraction using theophylline--experimental and clinical studies].
The tocolytic efficiency of theophylline was investigated in 24 uterine strips and in 31 patients with premature contractions. Frequency, duration, amplitude, area and activity of the strips spontaneous contractions were decreased highly significantly (p less than 0.01) after administration of theophylline. In patients with premature contractions complete success (prolongation until 37. week of pregnancy and longer) was achieved in 12/19 of the patients, incomplete success (prolongation for more than 6 days until prophylaxis with steroids was efficient) in 4/19 patients. In 3/19 patients no success was observed. Also bolus-administration before an acute caesarean demonstrated a satisfying tocolytic effect. No serious side-effects, especially of cardiopulmonal sort, were remarked, except of some nausea.
Culture Techniques↗
[Inhibition of uterine contractions by alpha adrenergic receptor blockaders].
In order to further investigate the adrenergic system of the pregnant uterus, the alpha 2-adrenoblocker Yohimbine and the alpha 1-alpha 2-blocker Phentolamine were examined in regard to their tocolytic effect on myometrial strips and compared with the relaxant effect of Prazosin which was already detected by our group. For both substances a highly significant decrease of uterine activity was found which did not differ from that of the alpha 1-blocker Prazosin.
Culture Techniques↗
[Myoglobin behavior with hexoprenaline and beta blockade].
The addition of the calcium-antagonist Verapamil in order to antagonize myocardial side-effects under tokolysis with beta-mimetic agents was more and more critisized in the last time. We have therefore combined the tocolytic agent Hexoprenalin with the beta 1-blocking agent Metroprolol in 24 patients and have analysed the myoglobin level before as well as two and four hours after the beginning of tokolysis. There was no increase of serum-myoglobin seen under this tocolytic regime.
Drug Therapy, Combination↗
[Effect of Listeria on contractibility of human uterine muscle].
In Austria the prevalence of listeriosis is 2.6 cases per million inhabitants yearly, hence rather rarely the cause of spontaneous abortion or premature birth. On the other hand, Listeria monocytogenes is found in 1% of the asymptomatic population as a component of stool flora. Since the cause of premature labour contractions remains unclear in about half of all cases, we examined 29 listeria strains for their ability to cause myometrial contraction by direct contact using an in-vitro uterine strip-model. Seven of nine L. monocytogenes strains were able to cause contractions; contractions were not inducible by an nonhaemolytic mutane (SLCC 53, avirulent) nor by a rough strain (SLCC 5779, only slightly virulent). Three of six L. ivanovii isolates also exhibited the ability to induce contractions. None of the apathogenic species (L. innocua, L. seeligeri, L. welshimeri, L. grayi and L. murrayi) was capable of activating contractions in our in-vitro model. Only L. monocytogenes and L. ivanovii cause conjunctivitis after being dropped in rabbit's eyes (positive Anton Test). The influence of listeria on uterine activity as found in our in-vitro model thus correlates with the classical pathogenicity test. We consider these in-vitro results as an additional argument to oppose the presence of L. monocytogenes in ready-to-eat foods.
Adult↗