Search PubMed⌕ Search

Biomedical subjects

W Lang

Publications and source records attributed to W Lang.

At least 361 records · Page 20Linked to original sources
PubMed1977

Studies on the percutaneous absorption of 3H-aescin in pigs.

Percutaneous absorption of aescin was measured following application of an aqueous solution of tritiated sodium aescinate to the ventral skin of pigs. Following single or repeated application at various intervals, the concentration of total activity, non-volatile activity and aescin activity following TLC was determined in different organs, tissues, blood and urine. Very high concentrations of aescin were found in skin and muscular tissues underlying the application site. Only low values were measured in internal organs, blood, urine, skin and musculature from other parts of the body. The concentration of non-volatile activity in subcutis is 50-600 and in musculature 10-50 times higher than in blood. Only 0.5 - 1% is excreted in urine within 24 hours of administration. The calculated total elimination (bile + urine) may be 1 - 2.5% of the dose. Barely one half is excreted as native aescin, the rest as volatile activity and different metabolites.

Animals↗
PubMed1977

Animal experiments on the question of the renal toleration of the horse chestnut saponin aescin.

The possibility that aescin might have a nephrotoxic side effect has been investigated by clearance studies in kidneys of healthy rats and by toleration studies in rats with damaged kidneys. The effect of aescin, both free and albumin-bound, on renal tubular transport processes was studied in the model of the isolated, artificially perfused frog kidney. The rates at which different concentrations of aescin were bound to rat plasma proteins were determined in vitro. The clearance of i.v. aescin was 13% of creatinine clearance and 7% of p-aminohippurate (PAH) clearance; this rules out the tubular secretion of aescin. No deaths occurred among aminonucleoside-damaged rats given i.v. sodium aescinate 2.2 mg/kg, but rats damaged with mercuric chloride or uranyl nitrate had exactly the same mortality rate as those given 2.2 mg/kg i.v. of sodium aescinate alone. The rats received four injections in all of aescin 0.35 mg/kg i.v., given at intervals of two days. Aescin had no effect on renal damage caused by aminonucleoside, mercuric chloride or uranyl nitrate. Aescin concentrations of 0.2 mg/l and 2.0 mg/l in the perfusion fluid increased the excretion of Na+ and glucose by the frog kidney and reduced the reabsorption of both these substances. With a sodium aescinate concentration of 5 mg/l the production of urine ceased. When 1% (w/v) of albumin was added to the perfusion fluid, even sodium aescinate 5 mg/l had no effect on the tubular transport of Na+, glucose and water. The fact that about 50% of aescin was not bound to plasma protein in vitro suggests that some of the small amount of aescin in the glomerular filtrate is reabsorbed in the tubules.

Animals↗
PubMed1976

[Controlled EEG alpha feedback training in normals and headache patients (author's transl)].

Headache patients and healthy controls underwent alpha-EEG feedback training in 12 sessions. The present study does not support the literature which reports alpha increase by feedback training. The study included a patient group receiving feedback, a patient control group receiving pseudofeedback, and a volunteer group receiving feedback. Increase of alpha EEG was observed under feedback and pseudofeedback. However, there was always more alpha during baseline times than during training times. Alpha increase over time is suggested to be a habituation effect. Headache pain decreased with training (within the boundaries of a placebo effect), and there was no difference in headache decrease between feedback and pseudofeedback patients.

Adult↗
PubMed1975

Deafness complicating mucous membrane pemphigoid: a case report.

A patient with moderately severe mucous membrane pemphigoid is described. The onset of deafness was associated with the appearance of postero-superior retraction prockets in both eardrums. It is postulated that this was due to mucous membrane pemphigoid involving the mucosa of the middle ear. We are not aware of this complication having been described previously.

Azathioprine↗