Studies of the immunologic defects associated with intestinal lymphangiectasia, with some observations on dietary control of chylous ascites.
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Agammaglobulinemia↗
Biomedical subjects
W L Trudeau
Publications and source records attributed to W L Trudeau.
House dust mite allergy in Florida. Mite survey in households of mite-sensitive individuals in Tampa, Florida.
This study evaluated the prevalence of positive house dust mite skin tests in a population of atopic individuals and identified the mite species present in mattress and house dust samples in homes of the Tampa Bay area. Four hundred consecutive individuals were evaluated for respiratory complaints and skin tested with standardized extracts of Dermatophagoides pteronyssinus (Dp) and Dermatophagoides farinae (Df). Two hundred forty individuals (60%) had a positive skin test to the mite extracts. Dust samples were collected in 40 homes of mite-allergic individuals and analyzed by light microscopy. Mite species were found in 53 of the 60 dust samples (20 mattresses and 40 carpets). Mite numbers ranged from 110-6200 mites/g of mattress dust and from 120-5500 mites/g of carpet dust. Eleven different mite species were identified and Blomia tropicalis (Bt), not previously identified in the United States, was found in 30% of the samples. Dp and Df wee the predominant species. These observations suggest that house dust mite allergy is common in the Tampa Bay area and that the house dust mite fauna comprises several mite species besides Dp and Df. Prospective studies in progress are designed to confirm the role of different mite species in house dust mite allergy.
Air Pollutants↗
Mite sensitivity and exposure in the city of Santa Fe, Argentina.
Little information is available on mite allergen levels and rates of sensitization to domestic mites in South America. The purpose of this study was to establish the rate of sensitization to domestic mites in asthmatics and measure mite allergen levels in pillows and mattresses of mite allergic individuals in Santa Fe, Argentina. Dust samples were collected from the pillows and mattresses of 56 asthmatics (24 females and 32 males, mean age 17.6 +/- 11.5 years), who had been previously skin tested with standardized extracts of Dermatophagoides pteronyssinus, Dermatophagoides farinae and (1:50 w/v) extracts of Aleuroglyphus ovatus, Blomia tropicalis, Chortoglyphus arcuatus. A wheal > or = 3 mm was considered positive. Sensitization to Lepidoglyphus destructor and Euroglyphus maynei was determined by RAST and considered positive when a serum bound > or = 1% of the total counts added. Forty six individuals had a positive skin test to D. pteronyssinus, 43 to D. farinae, 27 to A. ovatus, 38 to B. tropicalis, 27 to C. arcuatus; 38 of 54 individuals had a positive RAST to E. maynei and 22 of 54 to L. destructor. The mean Group 1 (Der p 1 + Derf 1) level in pillows (n = 48) was 6.7 micrograms/g (1-55.4) and in mattresses (n = 52) 4.3 micrograms/g (1-38.8). There is a high degree of sensitization to domestic mites among asthmatics in Santa Fe. High mite allergen levels (> 2 micrograms/g) can be detected very often in pillows and mattresses.
Adolescent↗
Serial determinations of Der p 1 and Der f 1 show predominance of one Dermatophagoides species.
One dust sample each month was collected for an average of 11 months throughout the year from the bedroom carpet of 39 mite allergic, asthmatic individuals living in the Tampa Bay area of Florida. Dust samples were collected from a square meter area from the bedroom carpet for 2 min using a portable vacuum cleaner and analyzed using two-site monoclonal antibody assays. The geometric mean of Dermatophagoides allergens Der p 1 and Der f 1 levels measured in each individual home was used in the statistical analysis of the results and reflects the average allergen level per year per home. Der p 1 levels were greater than Der f 1 in 21 homes; five homes had between 1.1 and 5 times more; one home had between 5 and 10; and 15 had between 10 and 175. Der f 1 levels were greater than Der p 1 in 18 homes; seven homes had between 1.1 and 5 times more; four had between 5 and 10; and seven homes had between 10 and 44. Spearman rank analysis of the results yielded a negative correlation coefficient (Rho) = -0.213 (p = 0.19) between Der p 1 and Der f 1 levels. These data suggest that when mite allergen levels reach a geometric mean value of approximately 2 micrograms/gram of dust throughout a year, one mite species predominates over the other.
Allergens↗