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Biomedical subjects

W L Johnson

Publications and source records attributed to W L Johnson.

At least 73 records · Page 4Linked to original sources
PubMed1979

Predictability of gestational hypertension.

Eighty-five women at 28-36 weeks' gestation were studied prospectively in a clinical research center to assess a "roll over test" (RT) based on the original study by Gant et al. Patients were admitted to the hospital, placed on bed rest, and given a balanced diet. The test started 12 hours after admission. Blood pressure was measured every 10 minutes for an hour with the patient in the left lateral position, and then in the supine position for a second hour. The mean diastolic blood pressure was calculated in each position and the patients were sorted into 6 groups based on the magnitude of change in blood pressure. Seventeen patients developed gestational hypertension (GH). Only 3 of 20 (15%) patients with a positive RT developed GH, while 14 of 65 (22%) patients with a negative RT developed GH. Five of 12 patients who had an actual decrease in mean diastolic blood pressure also developed GH.

Adolescent↗
PubMed1975

Pharmacologic control of uterine contractility. In vitro human and in vivo monkey studies.

The exact cause and mechanism of the onset of labor are unknown but the theories are many. There is considerable evidence that prostaglandins are potent stimulants of uterine activity and may play a role in the onset of labor. Prostaglandin release may be the natural mediator of uterine contractions during labor. A group of anti-inflammatory compounds (aspirin-like compounds) that inhibit prostaglandin synthesis include indomethacin and fenoprofen. Inhibition of prostaglandin production is a reasonable approach to inhibiting premature labor. An excised muscle strip technique was used as a screening procedure for pharmacologic depression of human uterine activity in vitro, testing isoxsuprine, mesuprine, Alupent, ritodrine, indomethacin, and fenoprofen. The prostaglandin antagonists indomethacin and fenoprofen exhibited marked depressant activity. These drugs were further tested in an in vivo rhesus monkey preparation measuring uterine activity, maternal blood pressure, uterine blood flow, fetal heart rate, fetal blood pressure, and blood gases. Fenoprofen is effective in reducing uterine contractility without serious maternal or fetal side effects and shows promise as a clinically effective agent for pharmacologic control of premature labor.

Adrenergic beta-Agonists↗
PubMed1975

Evaluation of human sera for antibodies against sperm by immunofluorescence.

Newborn cord sera and sera from pregnant women and from couples with unexplained infertility were observed by indirect immunofluorescence for reactions against human sperm. The sera from the infertile couples had been tested for macro-agglutination and complement-dependent immobilizing antibodies as well. Nonspecific fluorescence was noted only on the quatorial segment. Acrosomes and tail end-pieces were strongly immunofluorescent (positive at a serum dilution of 1:16) with 60 to 70% and 30 to 50%, respectively, of the sera from each main group, with the exception of the nonreactive cord blood. End-piece fluorescence was primarily due to the IgM globulin fraction. It is suggested that cord serum anti-sperm antibodies, directed mainly against the tail main piece, are due to IgG passively acquired from the mother. There was no apparent difference in immunofluorescence between infertile patients and control groups (except for the acrosome and end-piece, with cord sera). However, when the sera from infertile patients were subdivided into groups containing only agglutinating antibody, only immobilizing antibody, and both types of antibody, a higher percentage of the sera from the group having only agglutinating antibody reacted with all sperm areas. This reaction seemed more uniform over the sperm and included the usually negative posnuclear cap and midpiece. The other subgroups showed no obvious trends.

Acrosome↗
PubMed1975

Educational preparation for nursing--1974.

Each year a report of some of the most recent statistics on nursing education appears in the September issue of Nursing Outlook. The data presented are derived from The National League for Nursing's annual survey of state-approved schools of nursing in the 56 jurisdictions of the United States. The programs surveyed include those which prepare for beginning practice in nursing (baccalaureate, associate degrees, diploma, and practical nursing); those graduate programs that lead to masters and doctoral degrees in nursing; and those baccalaureate programs that conduct nursing programs for registered nurses only. Data on the status of state-approved basic schools (new schools, closed schools, and changes in existing schools) are obtained in September of each year from the state boards of nursing. In October, questionnaires are mailed to each school of nursing, as well as to those nursing programs that do not require state board approval (masters and doctoral programs, and baccalaureate programs for registered nurses). Information is also obtained from irregularly conducted surveys of all four-year colleges and universities in the United States that do not have state-approved basic nursing baccalaureate programs. The data obtained include admissions and graduations for the preceeding academic year, admissions for the current fall term, and enrollments as of October 15. Other information, such as data on men and minority students, is collected every three years. In recent years, enrollment figures for students who were admitted with advanced placement status have also been collected. With few exceptions, the schools have been most cooperative in providing the data, making it possible for us to obtain a 100 percent response rate for both registered nurse and practical nurse programs.

Education, Nursing↗