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Biomedical subjects

W L Broghamer

Publications and source records attributed to W L Broghamer.

26 records · Page 2Linked to original sources
PubMed1975

Selenium levels in human blood and tissues in health and in disease.

The levels of selenium in human sera and pancreatic, hepatic and synovial tissues were measured. An attempt was made to correlate the selenium level with certain disease states. Selenium was determined by nerutron activation analysis, using the 17.4 second half-life isotope 77mSe with a sensitivity of 2ppb. Serum-bound selenium was determined in normal individuals and individuals with various malignancies, and medical and surgical disorders. Tissue selenium was assayed in diseased and normal pancreases, livers, and synovial membranes. A wide variation was observed both in the serum selenium content of patients with a malignancy and in postmoren pancreatic and synovial showing histopathological changes. Significantly lower selenium values were observed in sera from cancer patients than from normal individuals. Higher values were generally observed in patients with primary neoplasms of the reticuloendothelial system. Higher tissue concentrations were obtained in synovia from patients with rheumatoid arthritis and in pancreatic tissues associated with histopathological changes.

Arthritis, Rheumatoid↗
PubMedDate not supplied

Cytologic negativity in the diagnosis of secondary pulmonary neoplasms.

This retrospective study consisted of 55 patients with histologically confirmed metastatic cancer to the lung. Cytologic specimens were collected within 45 days before death. These included bronchial secretions, pleural effusions, and fine needle aspirations obtained randomly, either singly or in various combinations. The cytodiagnosis of cancer was made in 58% (32/55) of the patients. Originally, 34% (11/32) of these had been false-negative cases. Morphologic features associated with cytologic negativity in 23 patients included apparent failure to invade the respiratory air compartment in 57% (13/23) of the cases; when applicable, failure to induce a pleural effusion with neoplastic invasion of pleural tissues in 75% (6/8); peripheral distribution of the metastatic nodules to the outer third of the pulmonary parenchyma in 26% (6/23); and tumor size of less than 1.5 cm in 57% (13/23).

Adenocarcinoma↗
PubMedDate not supplied

The cyto-histopathology of a pseudomesotheliomatous carcinoma of the lung.

A cyto-histopathologic study of a pseudomesotheliomatous carcinoma of the lung has been presented. The cytologic preparations of the early morning and post-bronchoscopy sputum specimens, bronchial washings and pleural fluid contained tumor cells similar to those exfoliated from a terminal bronchiolar carcinoma, of which this neoplasm is considered a variant.

Adenocarcinoma↗
PubMedDate not supplied

Cytohistologic correlation of urothelial lesions secondary to photodynamic therapy.

Qualitative cytologic evaluations of urinary bladder washings were performed on a selected population following photodynamic therapy for recurrent transitional cell carcinoma of the bladder. The seven patients were monitored trimonthly by cystoscopy, multiple biopsies and cytopreparations. Cancers reappeared in two of the five patients who initially responded to therapy. In the remaining two patients, the recurrent neoplasms were therapeutically refractory. Cytology detected recurrent cancer prior to biopsy confirmation and/or cytoscopic identification. Exfoliative cytology was correlated with the histopathology of the concurrent biopsies; a possible source for a false-positive cytodiagnosis was the cellular atypia of reepithelialized bladder mucosa. Dysplasia was not identified cytologically or histologically.

Biopsy↗
PubMedDate not supplied

Pulmonary cytology in the posttherapeutic monitoring of patients with bronchogenic carcinoma.

A study of 113 patients with histologically confirmed bronchogenic carcinoma and survival for at least 18 months was performed. Posttherapeutic cytologic specimens were submitted for only 52.2% (59/113), and for only 8.5% (5/59) of the individuals was specimen procurement related to clinic visits. Yet, when utilized as a diagnostic procedure for the hospitalized patient, a positive cytodiagnosis was made on 55.6% (15/27) of the patients with recurrent carcinoma, in 61.1% (11/18) with persistent disease and in all 5 patients with a metachronous primary bronchogenic carcinoma. Cytologic diagnoses of cancer compared favorably with concurrent histologic interpretations of biopsies and radiologic observations of chest films.

Bronchi↗
PubMedDate not supplied

Prostatic acid phosphatase immunoperoxidase staining of cytologically positive effusions associated with adenocarcinomas of the prostate and neoplasms of undetermined origin.

An immunoperoxidase staining technique was employed in an effort to demonstrate prostatic acid phosphatase in sections of the effusion cell blocks in a retrospective investigation of the incidence of malignant prostatic cells in body cavity effusions in 33 patients with histologically confirmed prostatic cancer. An attempt was also made to identify the prostate as a possible anatomic site of origin in 26 patients with an unknown primary but with cytologically positive fluids. Neoplastic cells were identified in the effusion specimens in 21.2% of the patients with confirmed prostatic cancer; the sources, however, were either primary or metastatic carcinomas of nonprostatic origin. None of the cytologic specimens in this study demonstrated a positive prostate-specific acid phosphatase staining reaction, as did the prostatic metastases to the lungs used as controls.

Acid Phosphatase↗
PubMedDate not supplied

Malignancy-associated serosanguinous pleural effusions.

Cytologic preparations of 786 pleural effusions from 495 patients were reviewed, including 312 specimens from 172 cancer patients. Approximately 50% of the paraneoplastic effusions were sanguinous. Thoracic cancer was histologically confirmed in 145 patients, 64% of whom had cytologically positive pleural effusions; 71% of these specimens were also macroscopically bloody. Regardless of any histologic evidence of neoplastic invasion of the pleura, the presence of blood in the majority of the effusions was related most often to acute inflammatory reactions with vascular dilatation and proliferation within serosal tissues or the underlying pulmonary parenchyma.

Blood↗