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PubMedDate not supplied

[Tests concerning the usefulness of serum myoglobin levels for the diagnosis of reperfusion in patients with imminent myocardial infarction].

Blood myoglobin, CPK and CK-MB activities were assayed in 32 patients with the acute myocardial infarction up to 360 minutes following the start of thrombolytic therapy. Plasma myoglobin, CPK and CK-MB activities increased significantly less in 18 patients in whom reperfusion of the coronary artery has been noted. Maximum increase in myoglobin levels preceded an increase in CPK and CK-MB activities and it may be an early marker of reperfusion.

Adult↗

PubMedDate not supplied

[Propafenone, flecainide, procainamide in the treatment of a fresh attack of atrial fibrillation].

The purpose of the present work was an assessment of the effectiveness of intravenously administered propafenone, flecainide and procainamide in restoration of sinus rhythm in patients with atrial fibrillation attack lasting not more than 48 hours, The studies were carried out in 95 patients, including 30 treated with propafenone, 27 with flecainide, and 38 with procainamide. Propafenone turned out to be effective in 23 patients (76.7%), flecainide in 19 patients (70.4%), and procainamide in 14 patients (36.8%). Each of the drugs more effectively restored sinus rhythm in patients with smaller size of the left atrium and with shorter duration of atrial fibrillation attack, and propafenone and flecainide were also more effective in younger patients. The return of sinus rhythm was accompanied a reduction of the size of the left atrium. None of the studied drugs caused any more important adverse effects.

Adult↗