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W Kothe

Publications and source records attributed to W Kothe.

At least 19 recordsLinked to original sources
PubMed1987

[Measurements of the tympanic cavity].

The angle between the annulus fibrocartilaginous and the superior crest of the petrous bone was measured with 14 (10 to 19) degrees. The height of the annulus was in our material 10.04 mm, the width 9.45 mm. Measured were also the length of the plicae malleares and the height of the recessus membrane tympani anterior, posterior et superior with (2.5, 3.0 and 1.5 mm). In about 74%, the chorda tympani was imbedded in different zones of the plicae malleares. Its entrance and exit areas, the length of its intratympanal course and its width were measured. Included are also values of the ligaments of the otic ossicles, measurements of the ostium tympanicum tubae auditivae, of the epitympanic recess, the aditus ad antrum, and the antrum mastoideum. The eminentia pyramidalis, the sinus posterior and the sinus tympani, ponticuli and subicula, the fossula fenestrae cochleae and the fenestra cochleae, the fenestra vestibuli and prominences of the facial canal in the lateral semicircular canal have been researched and measured. Also the tympanic nerve and its course on the promontorium have been estimated.

Ear, Middle↗
PubMed1986

[Immunologic characterization of the rejection of the allogenic transplanted kidney in pigs with and without immunosuppression].

After allogenic renal transplantation in pigs kinetics of the immunological reactivity have been investigated in order to diagnose rejection crisis. In a first series of 26 transplants without any immunosuppression we secured the diagnosis of rejection in 95% of cases of acute or chronic rejection by a combination of antigen-specific rosette test, inhibition of this parameter by autologous serum, complement dependent cytotoxicity and antibody dependent cell-mediated cytotoxicity. The antigen-specific rosette test reacts very early, 2-3 days before a bad clinical feeling in the course of acute rejection or 5-14 days by chronic rejection. Under the therapy with prednisolone and azathioprine we could not reach any prolongation of survival by arbitrary donor-recipient-selection. Under immunosuppression antibodies have never been observed by acute rejection in CDC and ADCC. In every case of acute rejection an increasing rosette formation of specific antigen binding cells appeared 2-3 days before an increasing of serum creatinine. In the case of other complications like infection or thrombosis this test is not reacting. However, by thrombosis of arteria or vena renalis there can be an increased specific rosette formation either independent of this process by beginning of immune reaction or by causal connection of both processes (necrotizing thrombotic rejection). So we have given the evidence, that the antigen-specific rosette test on a high level meets all requirements of a specific diagnosis of rejection under immunosuppression in pig.

Animals↗
PubMed1984

[The importance of active rosette-forming cells and specific antigen-binding cells in the diagnosis of rejection after allogeneic orthotopic kidney transplantation].

After allogeneic renal transplantation in 26 female pigs the kinetics of the immunological reactivity against the graft have been investigated with a specific test, the antigen specific rosette test and an unspecific test, the active E-rosette test. In acute and chronic rejection the level of antigen specific rosette forming cells reflects very well the clinical signs of rejection. Because of early occurrence of immunological reactivity in the case of frequent (daily) testing this test is suitable for a relative sure prediction of rejection episodes. In spite of their relative good correlations to the increase of serum creatinine, posttransplant increase and decrease of active rosette forming cells are not always in an uniform temporal relation to the rejection process. For that reason this test alone is not suitable for diagnosis of rejection. However, high preoperative values (greater than or equal to 18% active T cells) refer to an increased readiness to immunological reactivity of recipient against the graft and reflect contraindication to transplantation. If active rosette forming cells (greater than or equal to 18%) and antigen specific rosette forming cells show maxima at the same time, than follow in high significance strong cell mediated rejections. On this way the active E-rosette test completes the values of the antigen specific rosette test.

Animals↗
PubMed1983

[Employment of the antigen-specific rosette test in the diagnosis of rejection following allogeneic orthotopic kidney transplantation in the pig].

Investigations of the course were performed by means of an antigenspecific rosette test using a poolantigen from tissue samples of approximately 100 pigspleens with the help of the model of allogenic renal transplantation in 26 female pigs. The animals received no immunosuppressive treatment. In our study with this test 75% all of the rejection episodes by clinical acute and chronic rejection were predictably. In acute rejection a maximum rosette forming cell response was examined in general 2-3 days before a pathological rise of serum creatinine or in the course of a bad clinical state. Under chronic rejection this reaction can be seen 5-14 days before the kidney function will go poor. In spite of the high individuality of original curves statistical analyses indicate a good correlation of the number of antigenbinding cells toward pathological deviation of serum creatinine, as long as blocking factors not protect the transplant against the attack of persisting immunocompetent cells or their effectors. These blocking factors can be monitored in a rosette inhibition test with autolog serum.

Animals↗
PubMed1981

[Changes in serum parameters after oral alcohol intake in healthy men].

A short-time-study (1 to 24 hours) and a long-time-study (1 to 96 hours) after a single alcohol intake were made in 23 healthy probands. The pancreas and liver parameters as alpha-amylase, bilirubin, ASAT, ALAT, gamma-GT and GLDH in the serum were determined at regular intervals. The pancreas showed a sensitive reaction to alcohol expressed by an early rise of lipase activity. The liver enzymes of young healthy probands remained unchanged. Older probands, on the other hand, react by a distinct increase of the gamma-GT and GLDH as well as a decrease of the ASAT and ALAT. Also the enzyme quotients gamma-GT/ASAT and (ASAT + ALAT)/GLDH be obviously well suited to recognizing very early stages of liver lesion by serum examinations. For this purpose only a definite alcohol intake (I ml ethanol per kg body weight) is necessary.

Administration, Oral↗
PubMed1979

[Surgical treatment of hiatal hernias (author's transl)].

The diagnosis "hiatal hernia" does not equate with surgery, but if it is combined with disturbed function of the gastrooesophageal transitional area or reflux oesophagitis it needs therapy. Therefore, the diagnosis has to be made with care. Based on over 800 cases the intraluminal layered pH-metry proved to be a very helpful method. Paraoesophageal hernias should be surgically treated due to their tendency towards strangulation and incarceration. From 1956 to 1976 287 patients suffering from hiatal hernia were operated on, mortality rate and late results are analysed.

Gastroesophageal Reflux↗
PubMed1979

[Indication for treatment of gastric and duodenal ulcers by resection (BI/II) (author's transl)].

After exposing the indications for resections according to Billroth, the results achieved are analysed, advantages and disadvantages of the method are discussed with regard to late results. A strict indication lowers the motality rate, postprandial disorders, anastomotic ulceration and carcinoma of the gastric stump. New operative methods like vagotomy and its modifications should complete the surgical armamentarium, but cannot replace the classic gastric resection.

Disability Evaluation↗
PubMed1978

[The effect of truncular subdiaphragmatic vagotomy and pyloroplasty on the nitrogen balance in bionomal rat gastric surgery using the isotope labeled amino acid 15N-glycine].

By use of stable isotope labeled amin acid 15N-glycine the effects of truncular subdiaphragmatic vagotomy and of pyloroplasty, which are comprised in the method of bionomic gastric operations, were studied separately. The assessment of nitrogen equilibrium in rats after only truncular vagotomy, only pyloroplasty, truncular vagotomy combined with pyloroplasty, and without surgery serving as controls yielded results as following: After truncular vagotomy the 15N equilibrium was worse than in the control animals or after pyloroplasty only. The cause of that is an enhanced nitrogen loss in urine. After truncular vagotomy with pyloroplasty, though, 15N excretion in feces was significantly higher than after only pyloroplasty. It may be concluded from these results that truncular vagotomy is primarily responsible for the disturbances in protein metabolism. Pyloroplasty in combination with truncular subdiaphragmatic vagotomy also causes a higher nitrogen excretion in the feces indeed.

Animals↗
PubMed1978

[Gastric motility and selective proximal vagotomy (SPV)].

In the era of selective vagotomy the gastric motility is increasingly important. Measuring methods are demonstrated as to electromyography, intraluminal pressure measuring, measuring of emptying using isotope labeled food, and serial X-ray technique with amplifier photography. Measurings were performed in 12 patients, before and 4 months after selective proximal vagotomy. The bioelectric gastric activity is hardly influenced by selective proximal vagotomy. Enhanced antral peristalsis (tonic and peristaltic contraction) and delayed emptying are observed in cases without pyloroplasty. The authors therefore recommend that preoperative examination of motility in combination with intraoperative findings should indicate the pyloroplasty.

Gastric Emptying↗
PubMed1976

[Billroth II. Surgery of the stomach].

In different intervals 220 patients were examined after a resection of the stomach with Billroth's second operation. 179 of them spoke about complaints of different degrees of severity. The cases in question were an early dumping syndrome in 83 patients, which, with the exception of 7 patients, could be removed by simple dietetic measures, such as the elimination of incompatible foodstuff. Again and again the symptoms could be evoked by provocation with it. The method described by Henley proved as correcting operation. Apart from a few exception the fitness for work was not restricted by Billroth's second operation. In shift work or severe physical work a change of the working place was striven for. The body-weight which was reduced already before the operation again increased after operation in 50%, but reached the normal only in 20%. Recidivation ulcera and anastomositis of a suture were rare findings. Stump gastritis is no own clinical picture. Also in this case in histologically still normal mucous membrane earlier histochemical changes develop in the sense of a chronic gastritis with a reduction of the adenosin triphosphatase, the acid tissue phosphatase and succinodehydrogenase.

Adult↗
PubMed1976

[Results of treatment of cholelithiasis and its consequences; the so called "postcholecystectomy-syndrome" (author's transl)].

Our analysis of 378 patients made after operations for diseases of the gallbladder and bile tract underlines the demand of an exact preoperative diagnostic examination of other abdominal organs, e.g. the oesophagus, stomach, duodenum, liver and pancreas. The value of using modern intraoperative diagnostic procedures for the biliary tract is confirmed. Our analysis also demonstrates the necessity of traeting cholelithiasis surgically at an early stage. Complications of cholelithiasis include a higher risk, a worse prognosis with regard to permanent healing and a higher rate of postoperative lethality.

Bile Ducts↗