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Biomedical subjects

W Keup

Publications and source records attributed to W Keup.

At least 19 recordsLinked to original sources
PubMed1996

[MDMA--"ecstasy"].

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Cross-Sectional Studies↗
PubMed1986

Use, indications and distribution in different countries of the stimulant and hallucinogenic amphetamine derivatives under consideration by WHO.

Information is presented on legal manufacture, distribution, medical uses and in various countries of the stimulants and hallucinogens under consideration by the World Health Organization (WHO). Data are reported from the Substance Abuse Warning System (SAWS) in the F.R.G. and other surveillance systems regarding illicit manufacture, trafficking and abuse of these compounds internationally. In addition, it is pointed out that assessment of the liability of these compounds for abuse must consider not only the substance itself but also its potential metabolic products. These data, collectively, indicate that the substances currently of most concern with respect to abuse are fenetylline and norpseudoephedrine.

Amphetamines↗
PubMed1981

[The drug scene].

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Adolescent↗
PubMed1975

On the origin of desmethyl imipramine in rat brain.

The formation of DMI after incubation of IP-C-14 with supernatant fractions prepared from brain and liver of male Wistar rats were studied to determine the sources of DMI in brain tissue. IP and its metabolites were isolated by thin layer chromatography, eluted and counted in a Geiger-Muller counter. A substantial amount of DMI was formed when the liver supernatant fraction was used, whereas the brain fraction did not form DMI even at low level. Under the incubation condition used, about 2.7% of IP was converted non-enzymatically to a DMI-like substance. Based on the results presented it appears that at least most of the DMI reported by other authors to be formed in rat brain after IP administration, reaches the brain via the blood stream.

Animals↗