Biomedical subjects

W K Stewart

Publications and source records attributed to W K Stewart.

At least 91 records · Page 5Linked to original sources

PubMed1976

Haemoglobin and serum iron responses to periodic intravenous iron-dextran infusions during maintenance haemodialysis.

Patients with chronic renal failure who were on maintenance haemodialysis, were given monthly 600 mg iron intravenously as iron-dextran complex to a body replacement total of 5-6 g iron. Those patients who had been on maintenance haemodialysis for a long period and had received numerous blood transfusions failed to show a rise in haemoglobin levels. Those patients who received iron from the commencement of maintenance dialysis, and who had not received blood transfusions, showed a significant increase in haemoglobin concentrations which has been maintained for more than 18 months after iron therapy ceased, despite a concurrent decrease in serum iron concentrations. Pre-treatment and post-treatment levels of serum iron are not of predictive value for the success of iron treatment, neither for the haemoglobin nor the serum iron response. A body replacement dose of iron given intravenously over a year benefits the majority of patients on maintenance haemodialysis and is recommended for the treatment of their anaemia.

Anemia↗

PubMed1975

Gastric function in chronic renal failure. Effects of maintenance haemodialysis.

40 patients with chronic renal failure have been studied in order to determine why some patients with azotaemia have previously been reported to secrete abnormally large amounts of acid and some to secrete very little. 15 of the 40 patients were undergoing regular haemodialysis, while the remaining 25 patients had not been so treated. 10 of the 25 non-dialysed patients had much-impaired capacity to secrete acid. The impaired gastric secretory capacity was corrected and became abnormally great after some months of regular haemodialysis in 4 patients. Regular haemodialysis, by removing factors responsible for the gastric mucosal damage, permits manifestations of an underlying gastric hypersecretory state.

Creatinine↗

PubMed1975

Whole body potassium in patients with ureterosigmoid anastomoses.

Total body potassium was measured by whole body counting in 11 patients with uretero-sigmoid anastomoses who had undergone cystectomy 4 months to 13 years previously. The measured total body potassium was not significantly different in any of the patients from the "normal" value for the individual patients, predicted from height and age. It was only significantly different from that predicted from height, age and weight in 1 patient. In the series as a whole, the measured values of whole body potassium were not significantly different from the "normal" values estimated by either relationship. From measurements of skinfold thickness, the lean body mass of each patient was estimated. The mean potassium content, 62-0 mEg/kg LBM in the male patients was within the normal range. The absence of potassium depletion may derive from the successful abolition of hyperchloraemic acidosis by long-term alkali therapy.

Aged↗

PubMed1975

The long-term management and social consequences of ureterosigmoid anastomosis.

It is regrettable that while the recognised complications of ureterosigmoid anastomosis - recurrent urinary tract infection, and acidosis- can be avoided and obstructive uropathy can be recognised early and so treated, the operation frequently condemns the patient to a restricted life with an unpleasant ritual of bowel frequency and incontinence. It seems that the lack of awareness of this bizarre life-style and the occasional true successes have allowed the operation to remain in use. Our experience confirms the unpredictability of the end result of ureterosigmoid anastomosis and suggests that the operation should be largely abandoned, in favour of the conduit type procedure.

Acidosis↗

PubMed1974

Further studies of gastric hypersecretion in chronic renal failure.

The effect of medical treatment has been studied in four patients with end-stage renal failure who suffered from severe spontaneous gastric hypersecretion, associated with very low levels of intraduodenal pH in two cases. Atropine decreased the overnight gastric acid output, but the residual acid secretion and duodenal content of acid remained dangerously high in one of the patients. Secretin inhibited the basal gastric secretion of acid in all cases and converted the pH of the duodenal contents to alkaline. While atropine cannot be used to control the gastric hypersecretion, secretin may prove to be valuable in the therapeutic management of the gastric hypersecretion of patients with chronic renal failure.

Bicarbonates↗

PubMed1974